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Oviduct-specific Glycoprotein 1 Locus is Associated with Litter Size and Weight of Ovaries in Pigs
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 Title & Authors
Oviduct-specific Glycoprotein 1 Locus is Associated with Litter Size and Weight of Ovaries in Pigs
Niu, B.Y.; Xiong, Y.Z.; Li, F.E.; Jiang, S.W.; Deng, C.Y.; Ding, S.H.; Guo, W.H.; Lei, M.G.; Zheng, R.; Zuo, B.; Xu, D.Q.; Li, J.L.;
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Oviduct-specific glycoprotein 1 (OVGP1) is implicated in playing a role in fertilization and early embryo development. In this study, we have obtained the sequence of intron 9 of OVGP1 gene in swine. Comparative sequencing of Meishan (a native Chinese breed) and Large White pig breeds revealed an A/T substitution at position 943. A PCR-EcoRI-RFLP assay was developed to detect this mutation. Polymorphism analysis in Qingping animals showed that pigs with BB genotype had lower number of piglets born alive (NBA) in multiple parities than pigs with AA (p<0.05) and AB genotype (p<0.01). In Large () offspring, the weight of both ovaries (OW) of the BB genotype was significantly lighter than that of AB (p = 0.05) and AA (p<0.01) genotypes. Analysis of the data also revealed that the mutation locus affected these two traits mostly by additive effects. These studies indicated that the polymorphism was associated with NBA and OW in two distinct populations and further investigations in more purebreds or crossbreds are needed to confirm these results.
Oviduct-specific Glycoprotein 1;Litter Size;Female Reproductive Tract Components;Pigs;
 Cited by
Agarwal, A., W. S. Yeung and K. F. Lee. 2002. Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. Mol. Hum. Reprod. 8:167-75 crossref(new window)

Andrew, J. K., R. A. Lalantha, M. A. Idania, N. D. Billy and C. B. William. 2000. Effects of the porcine oviduct-specific glycoprotein on fertilization, polyspermy and embryonic development in vitro. Mol. Reprod. 63:242-250

Arias, E. B., H. G. Verhage and R. C. Jaffe. 1994. Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. Biol. Reprod. 51:685-94 crossref(new window)

Bhatt, P., K. Kadam, A. Saxena and U. Natraj. 2004. Fertilization, embryonic development and oviductal environment: role of estrogen induced oviductal glycoprotein. Indian. J. Exp Biol. 42:1043-55

Boatman, D. E. 1997. Responses of gametes to the oviductal environment. Hum. Reprod. 12:133-49

Legault, C., J. Gruand, J. Lebost, H. Garreau, L. Ollivier, L. A. Messer and M. F. Rothchild. 1996. Frequency and effect on prolificacy of the ESR gene in two French Large White liens. J. Rech. Porcine France. 28:9-14

Li, F. E., M. G. Lei, R. Zheng, B. Zuo, S. W. Jiang, C. Y. Deng and Y. Z. Xiong. 2004. The effects of esteogen receptor locus on reproductive tracts components and performance traits in large white$\times$meishan F2 offspring. Asian-Aust. J. Anim. Sci. 17:1223-1226

Li, F. E., Y. Z. Xiong, C. Y. Deng, S. W. Jiang and Z. Rong. 2002. Frequencies inheritance of FSH-$\beta$retroposon and its association with reproductive traits. Asian-Aust. J. Anim. Sci. 15:179-183

Lin, H. 1992. Porcine Dissection Map. 1th Ed. Agricultural Publishers of P.R.China, Beijing. 158

Liu, B. H. 1998. Statistical genomics: linkage, mapping, and QTL analysis. CRC Press, LLC

Lok, I. H., C. M. Briton-Jones, P. M. Yuen and C. J. Haines. 2002. Variable expression of oviductin mRNA at different stages of human reproductive cycle. J. Assist Reprod Genet. 19:569-76 crossref(new window)

Malette, B., Y. Paquette, Y. Merlen and G. Bleau. 1995. Oviductins possess chitinase- and mucin-like domains: a lead in the research for the biological function of these oviduct - specific ZP- associating glycoproteins. Mol. Reprod. 41:384-397 crossref(new window)

O'Day-Bowman, M. B., P. A. Mavrogianis, A. T. Fazleabas and H. G. Verhage. 1995. A human oviduct-specific glycoprotein: synthesis, secretion and localization during the menstrual cycle. Microsc. Res. Tech. 32:57-69 crossref(new window)

O'Day-Bowman, M. B., P. A. Mavrogianis, L. M. Reuter, D. E. Johnson, A. T. Fazleabas and Verhage. 1996. HG Association of oviduct-specific glycoproteins with human and baboon (Papio anubis) ovarian oocytes and enhancement of human sperm binding to human hemizonae following in vitro incubation. Biol. Reprod. 54:60-9 crossref(new window)

Rapisarda, J. J., P. A. Mavrogianis, M. B. O'Day-Bowman, A. T. Fazleabas and H. G. Verhage. 1993. Immunological characterization and immunocytochemical localization of an oviduct-specific glycoprotein in the human. J. Clin. Endocrinol. Metab. 76:1483-8 crossref(new window)

Rothschild, M. F., C. Jacobson and D. Vaske. 1996. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proceeding of the National Academy of Sciences of the United States of Amercia. 93:201-205

Rothschild, M. F., L. Messer and A. Day. 2000. Investigation of the retionl-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mamm. Genome. 11:75-77 crossref(new window)

Schmidt, A., P. A. Mavrogianis, M. B. O'Day-Bowman and H. G. Verhage. 1997. Species-specific effect of oviductal glycoproteins on hamster sperm binding to hamster oocytes. Mol. Reprod. 46:201-207 crossref(new window)

Short, T. H., M. F. Rothchild and O. L. Southwood. 1997. Effect of the estrogen receptor locus in reproduction and production traits in four commercial pig lines. J. Anim. Sci. 75:3138-3124

Vincent, A. L., G. Evans, T. H. Short, O. I. Southwood, G. S. Plastow, C. K. Tuggle and M. F. Rothchild. 1998. The prolactin receptor gene is associated with increased litter size in pigs. In: Proceedings of the 6th World Congress on Genetics Applied to Livestock Production. Arimidale, Australia. 27:15- 18

Xiong, Y. Z. 1999. Pig Biochemistry and Molecular Genetics: Experimental Introduction. 1th Ed. Agricultural Publishers of P. R. China, Beijing. 39-41

Zhang, Z. B., M. G. Lei, C. Y. Deng, Y. ZH. Xiong, B. Zuo and F. E. Li. 2005. Lipoprotein lipase gene and productive traits in pig resource family. Asian-Aust. J. Anim. Sci. 18:458-462

Zhao, Y. F., N. Li and Y. F. Chan. 1998. Preliminary research on RFLPs on FSH$\beta$ subunit gene. Acta. Veter. Zootech. Sin. 29:23-26