Advanced SearchSearch Tips
Effects of Dietary Iodine and Selenium on the Activities of Blood Lymphocytes in Laying Hens
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effects of Dietary Iodine and Selenium on the Activities of Blood Lymphocytes in Laying Hens
Song, Zhigang; Guo, Yuming; Yuan, Jianmin;
  PDF(new window)
The effect of dietary iodine and selenium supplementation, alone or in combination, on peripheral blood lymphocyte function was determined in laying hens. Eight-hundred-and-sixty-four New-Loman laying hens were randomly allotted into 12 dietary treatments with different inclusion levels of iodine (0, 0.1 and 0.2 mg/kg), selenium (0, 0.05, 0.1 and 0.2 mg/kg) or their combinations for 24 weeks. The lipopolysaccharide (LPS) stimulation index, concanavalin A (ConA) stimulation index, peroxide enzyme activity and phagocytosis to neutral red particles were tested. There were significant differences in LPS stimulation index, ConA stimulation index, peroxide enzyme activity and phagocytosis to neutral red particles in different iodine or selenium supplementation levels (p<0.05). The highest iodine and selenium supplementation both resulted in highest LPS-/ConA-stimulation indices (p<0.05). However, when iodine was lower than 0.2 mg/kg, the additional effect of different levels of selenium did not always result in significant differences in these indices. The results indicated that iodine and selenium may affect immunity in laying hens and, when the iodine level in the laying hen is lower than 0.2 mg/kg, a selenium allowance higher than 0.1 mg/kg may be necessary to improve immunity.
Laying Hens;Iodine;Selenium;Lymphocyte;Immune Function;
 Cited by
Selenium in Food Chain and Animal Nutrition: Lessons from Nature -Review-,Lyons, M.P.;Papazyan, T.T.;Surai, P.F.;

Asian-Australasian Journal of Animal Sciences, 2007. vol.20. 7, pp.1135-1155 crossref(new window)
Immune Response and Plasma Alpha Tocopherol and Selenium Status of Male Buffalo (Bubalus bubalis) Calves Supplemented with Vitamin E and Selenium,Shinde, P.L.;Dass, R.S.;Garg, A.K.;Chaturvedi, V.K.;

Asian-Australasian Journal of Animal Sciences, 2007. vol.20. 10, pp.1539-1545 crossref(new window)
Effect of Sodium Selenite and Zinc-L-selenomethionine on Performance and Selenium Concentrations in Eggs of Laying Hens,Chantiratikul, Anut;Chinrasri, Orawan;Chantiratikul, Piyanete;

Asian-Australasian Journal of Animal Sciences, 2008. vol.21. 7, pp.1048-1052 crossref(new window)
Anita, S., P. S. Singha, K. S. Dhillon and Shashi Nayyar. 2004. Antioxidant Enzymes in Postpartum Anoestrus Buffaloes Supplemented with Vitamin E and Selenium. Asian-Aust. J. Anim. Sci. 17:608-611

Arthur, J., R. Roderick, C. McKenzie and Geoffrey J. Beckett. 2003. Selenium in the immune system. J. Nutr. 133:1457s- 1459s

Cheng, T. SH. 2004a. Regulation of Zinc Amino Acid Complex on the Performance, Immune Responses and Antioxidant Capacity in Hens. Ph.D. Thesis, China Agricultural University

Cheng, T. SH. and Y. M. Guo. 2004b. Effects of Salmonella Typhymurium Lipopolysaccharide Challenge on the Performance, Immune Responses and Zinc Metabolism of Laying Hens Supplemented with Two Zinc Sources. Asian-Aust. J. Anim. Sci. 17:1717-1724

Chen, Y. 1980. Effect of thyroxine on the immune response of mice in vivo and in vitro. Immunol. Comm. 9(3):269

Contempre, B., J. E. Dumont and B. Ngo. 1991. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J. Clin. Endocrinol. Metab. 73:213-215 crossref(new window)

Davey, J. C., K. B. Becker and V. A. Galton. 1995. Cloning of a cDNA for the type II iodothyronine deiodinase. J. Biol. Chem. 270:26780-26786

DePalo, D., W. B. Kinlaw, C. Q. Zhao and D. L. St-Germain. 1994. Effect of selenium deficiency on type I 5'-deiodinase. J. Biol. Chem. 269(23):16223-16228

Ernstrom, U. and B. Lasson. 1966. The influence of thyroxine on blood lymphocytes. Acta path. Microbial. Scand. 51:17

Fabris, N., W. Pierpaoli and E. Sorkin. 1971. Hormones and the immunological capacity. IV. Restorative effect of developmental hormones or of lymphocytes on the immune deficiency syndrome of dwarf mouse. Clin. Exp. Immun. 9:227-240

Fabris, N. 1973. Immunodepression in thyroid-deprived animals. Clin. Exper. Immunol. 15:601-611

Fang, H. 2000. The study on the effects of iodine deficiency and iodine excess on the expression on thyroid TG and TPO mRNA in rats. Ph.D. Thesis, Tianjin Medical University, China

Follett, B. K. and C. Potts. 1990. Hypothyroidisan effects reproductive refractoriness and the seasonal oestrus period in Welsh Mountain ewes. J. Endocrinol. 127:103-109 crossref(new window)

Guo, Y. M. 1999. The necessity of selenium to normal thyroid hormone metabolism and the influence of selenium deficiency on the metabolism of sulphur-containing compounds. Ph.D. Thesis, China Agricultural University

Gupta, M. K., T. Chiang and S. D. Deodhar. 1983. Effect of thyroxine on immune response in C57B1/6J mice. Acta Endocr. Copenh. 103:76-80

Hayirli, A., N. Esenbuga, M. Macit, E. Lacin, M. Karaoglu, H. Karac and Yildiz. 2005. Nutrition Practice to Alleviate the Adverse Effects of Stress on Laying Performance, Metabolic Profile, and Egg Quality in Peak Producing Hens:1 The Humate Supplementation. Asian-Aust. J. Anim. Sci. 18:1310- 1319

Hotz, C. S., D. W. Fitzpatrick, K. D. Trick and M. R. L'Abbe. 1997. Dietary iodine and selenium interact to affect thyroid hormone metabolism in rats. J. Nutr. 127:1214-1218

Keast, D. and K. Taylor. 1982. The effect of tri-iodothyronine on the phytohaemagglutinin response of T lymphocytes. Clin. Experi. Immunol. 47:217-220

Leonard, J. L. and T. J. Visser. 1986. "Biochemistry of deiodination", in (G. Hennemann), Thyroid Hormone Metabolism, Marcel Dekke, New York, NY, pp. 189-222

Lin, Q. H. 1999. Lymphocytes transformation test. In: Methods of Immune Research (Ed. Q. H. Lin) Wuhan University Press. Wuhan, China. (in Chinese), pp. 188-190

Liu, Y. 2004. Effects of $\beta$-1,3/1,6-glucan on performance and immune response of broilers. Ph.D. Thesis, China Agricultural University

Lundell, G. and H. Blomgren. 1976. Lymphocyte populations in peripheral blood in hyperthyroid and euthyroid subjects. Clin. Experi. Iimmunol. 23:33-39

Miller, J. K., E. W. Swanson, W. A. Lyke and W. F. Byrne. 1974. Effect of thyroid status on digestive tract fill and flow rate of undigested residues in cattle. J. Dairy Sci. 57:193-197

Mu Li, Creswell J. Eastman and Steven C. Boyages. 1993. Iodine indeced lymphocytic thyroiditis in the BB/W rat: early and late immune phenomena. Autoimmunity 14:181-187 crossref(new window)

National Research Council. Nutrient Requirements of Poultry [M], Ninth Revised Edition. National Academy Press, 1994, Washington, DC

Orville, A. Levander and Philip, D. Whanger. 2000. Deliberations and evaluations of the approaches, endpoints and paradigms for selenium and iodine dietary recommendations. J. Nutr. 126:2427s-2434s

Paavonen, T. 1982. Enhancement of human B lymphocyte differentiation in vitro by thyroid hormone. Scand. J. Immunol. 15:211-215 crossref(new window)

Philip, S., M. D. Schoenfeld and W. James. 1995. Suppression of cell-mediated immunity in hypothyroidism. Immunity and Hypothyroidism 88(3):347-349

Ramauge, M., S. Paullud, A. Esfandiari, J. M. Gavaret and F. Courtin. 1996. Evidence that type III iodothyronine deiodinase in rat astrocyte is a selenoprotein. Endocrinol. 137:3021-3025 crossref(new window)

Schimizu, M. and Y. Schimizu. 1979. Lymphocyte proliferative response to viral antigen in pigs infected with transmissible gastroenteritis virus. Infect. Immun. 23:239

Schone, F., H. Ludke, A. Hennig and G. Jahreis. 1988. Copper and iodine in pig diets with high glucosinolate rapseed meal: II. Influence of iodine in pig diets with rapseed meal untreated or treated with copper ions on performance and thyroid hormone status of growing pigs. Anim. Feed Sci. Technol. 22:45-59 crossref(new window)

Shen, H. M., C. F. Yang and C. N. Ong. 1999. Sodium seleniteinduced oxidative stress and apoptosis in human hepatoma HepG(2) cells. Int. J. Cancer 81:820-828 crossref(new window)

Tizard, I. 1987. Veterinary Immunology: An introduction (3rd Ed.) W. B. Saunders, Philadelphia, P.A

Wang, G. Y. and Z. B. Lin. 1997. Effects of 10-hydroxy-2- decenoic acid phagocytosis and cytokines production of peritoneal macrophage in vitro. Pharmachalogia Sinaica. 18(2):180-182

Wayne, Chris Hawkes and Nancy, L. Keim. 2003. Dietary selenium intake modulates thyroid hormone and energy metabolism in men. J. Nutr. 133:3443-3448

Ganong, W. F. 2001. Review of Medical Physiology, Twentieth Edition. New York: McGraw-Hill, Inc., pp. 307-321

Xia, Z. G., Y. M. Guo, S. Y. Chen and J. M. Yuan. 2003. Effects of dietary polyunsaturated fatty acids on antibody production and lymphocyte proliferation of laying hens. Asian-Aust. J. Anim. Sci. 16:1320-1325