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Polymorphism of Insulin-like Growth Factor Binding Protein-4 Gene in 17 Pig Breeds and Its Relationship with Growth Traits
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 Title & Authors
Polymorphism of Insulin-like Growth Factor Binding Protein-4 Gene in 17 Pig Breeds and Its Relationship with Growth Traits
Wang, Wenjun; Hu, Xiaoxiang; Fei, Jin; Meng, Qinyong; Li, Ning;
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 Abstract
Insulin-like growth factor binding protein-4 (IGFBP-4) is a member of the IGF super family, and regulates the action of IGFs. The polymorphism of porcine IGFBP-4 gene in 17 pig breeds (total n = 570) was detected by PCR-SSCP, and alleles A and B were detected. In these pig breeds, it was found that exotic pig breeds carried high frequencies of allele A, while Chinese native pig breeds carried high frequencies of allele B. The role of porcine IGFBP-4 was investigated in 172 F2 offspring of a population. Forty eight growth traits were recorded for analyzing the association between IGFBP-4 gene polymorphism and quantitative performance traits. In this resource family, pigs with AA genotype had higher fore-body weight, bone weight of mid-body, bone weight of rear-body, fore-leg weight and rear-leg weight than those pigs with BB genotype (p<0.05); while pigs which carried BB genotype had higher back-fat thickness at C point and lard weight than those pigs with AA genotype (p<0.05); pigs with AA genotype had higher body weight than those with BB genotype; for meat quality traits, pigs with AA genotype had higher meat color than those of BB genotype (p<0.01), and pigs with BB genotype had higher marbling than those of AA and AB genotypes (p<0.01 and p<0.05, respectively).Based on these results, it is necessary to do more studies on IGFBP-4 before using the IGFBP-4 locus for the application of marker-assisted selection programs.
 Keywords
IGFBP-4 Gene;Performance Traits;Swine;PCR-SSCP;
 Language
English
 Cited by
 References
1.
Allander, S. V., S. Bajalica, C. Larsson, H. Luthman, D. R. Powell, I. Stern, G. Weber, H. Zazzi and E. Ehrenborg. 1993. Structure and chromosomal localization of human insulin-like growth factor-binding protein genes. Growth. Regul. 3:3-5.

2.
Clapper, J. A., T. M. Clark and L. A. Rempel. 2000. Serum concentration of IGF-I, estradiol-17$\beta$, testosterone, and relative amounts of IGF-binding proteins (IGFBP) in growing boars, barrows, and gilts. J. Anim. Sci. 78:2581-2588.

3.
Cohick, W. S., A. Gockerman and D. R. Clemmons. 1993. Vascular smooth muscle cells synthesize two forms of insulinlike growth factor binding proteins which are regulated differently by the insulin-like growth factors. J. Cell. Physiol. 157:52-60. crossref(new window)

4.
Gerrard, D. E., C. S. Okamura and A. L. Grant. 1999. Expression and location of IGF binding proteins-2, -4, and -5 in developing fetal tissue. J. Anim. Sci. 77:1431-1441.

5.
Harrell, R. J., M. J. Thomas, R. D. Boyd, S. M. Czerwinski, N. C. Steele and C. Bauman. 1999. Ontogenic maturation of the somatotropin/insulin-like growth factor axis. J. Anim. Sci. 77:2934-2941.

6.
Hathaway, M. R., W. R. Dayton, M. E. White and M. S. Pampush. 2003. Effects of antimicrobials and weaning on porcine serum insulin-like growth factor binding protein levels. J. Anim. Sci. 81:1456-1463.

7.
Jones, J. I. and D. R. Clemmons. 1995 Insulin-like growth factors and their binding proteins: Biological actions. Endocr. Rev. 16:3-34.

8.
Kelly, K. M., Y. Oh, S. E. Gargosky, Z. Gucev, T. Matsumoto, V. Hwa, L. Ng, D. M. Simpson and R. G. Rosenfeld. 1996. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. Int. J. Biochem. Cell. Biol. 28:619-637. crossref(new window)

9.
Lawrence, A. Wetterau, Michael G. Moore, Kuk-Wah Lee, Melanie L. Shim and Pinchas Cohen. 1999. Novel Aspects of the Insulin-like Growth Factor Binding Proteins. Molecul. Genet. Metab. 68:161-181. crossref(new window)

10.
Le Roith, D., C. Bondy, S. Yakar, J. L. Liu and A. Butler. 2001. The somatomedin hypothesis: 2001. Endocr. Rev. 22:53-74. crossref(new window)

11.
Li Jiaqi. 2001.QTL mapping and analysis of candidate gene for important economic traits in swine. Dissertation for Doctoral Degree. SouthChina Agricultural University, Guangzhou, Guangdong, P. R. China (in Chinese)

12.
Malek, M., J. C. M. Dekkers, H. K. Lee, T. J. Baas and M. F. Rothschild. 2001a. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. I. Growth and body composition. Mamm. Genome. 12:630-636. crossref(new window)

13.
Malek, M., J. C. M. Dekkers, H. K. Lee, T. J. Baas and M. F. Rothschild. 2001b. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. I. Growth and body composition. Mamm. Genome. 12:637-645. crossref(new window)

14.
Mohan, S., C. M. Bautista, J. Wergedal and D. J. Baylink. 1989. Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action. Proc. Natl. Acad. Sci. USA. 86:8338-8342.

15.
Muller, E., G. Moser, H. Bartenschlager and H. Geldermann. 2000. Trait values of growth, carcass and meat quality in Wild Boar, Meishan and Pietrain pigs as well as their crossbred generations. J. Anim. Breed. Genet. 117:189-202. crossref(new window)

16.
Paszek, A. A., P. J. Wilkie, G. H. Flickinger, G. A. Rohrer, L. J. Alexander, C. W. Beattie and L. B. Schook. 1999. Interval mapping of growth in divergent swine cross. Mamm. Genome. 10:117-122. crossref(new window)

17.
Paszek, A. A., P. J. Wilkie, G. H. Flickinger, G. A. Rohrer, L. J. Alexander, C. W. Beattie and L. B. Schook. 1999. Interval mapping of growth in divergent swine cross. Mamm. Genome. 10:117-122. crossref(new window)

18.
Rechler, M. M. 1993. Insulin-like growth factor binding proteins. Vitam. Horm. 47:1-114. crossref(new window)

19.
SAS. 1989. SAS User's Guide. SAS Inst. Inc., Cary, NC.

20.
Shimasaki, S. and N. Ling. 1991. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6). Prog. Growth. Factor. Res. 3:243-266. crossref(new window)

21.
Shimonaka, M., R. Schroder, S. Shimasakai and N. Ling. 1989. Identification of a novel binding protein for insulin-like growth factors in adult serum. Biochem. Biophys. Res. Commun. 165:1890-1895.

22.
Wang, J., W. Niu, D. P. Witte, S. D. Chernausek, Y. E. Nikiforox, T. L. Clemens, B. Sharifi, A. R. Strauch and J. A. Fagin. 1998. Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinol. 139:2605-2614. crossref(new window)

23.
Wang,, W. J., Y. H. Zhao, Y. H. Zhang and N. Li. 2005. Assignment of porcine insulin-like growth factor-binding protein-4 (IGFBP4) to SSC12 by fluorescence in situ hybridization and radiation hybrid mapping. Anim. Genet. 36: 522-523. crossref(new window)

24.
Wang Wenjun, Huang Lusheng, Gao Jun, Chen Kefei and Ren Jun. 2003. Polymorphism of growth hormone gene in 12 pig breeds and its relationship with growth and carcass traits. Asian-Aust. J. Anim. Sci. 16:161-164.

25.
Wenjun Wang, Kehui Ouyang, Xifan Su, Mingsheng Xu and Xinchen Shangguan. 2006. Polymorphism of Insulin-like Growth Factor 1 Receptor Gene in 12 Pig Breeds and Its Relationship with Pig Performance Traits. Asian-Aust. J. Anim. Sci. 19:1541-1545.

26.
Yue, G., J. R. J. Schröffel, G. Moser, H. Bartenschlager, G. Reiner and H. Geldermann. 2003. Linkage and QTL mapping for Sus scrofa chromosome 12. J. Anim. Breed. Genet. 120 (Suppl. 1) 95-102.

27.
Zazzi, H., A. Nikoshkov, K. Hall and H. Luthman. 1998. Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4). Genomics. 49:401-410 crossref(new window)