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Association of SNP Marker in the Leptin Gene with Carcass and Meat Quality Traits in Korean Cattle
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 Title & Authors
Association of SNP Marker in the Leptin Gene with Carcass and Meat Quality Traits in Korean Cattle
Shin, S.C.; Chung, E.R.;
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 Abstract
Leptin is the hormone product of the obese gene and is synthesized and secreted predominantly by white adipocytes and relates to the feedback system that regulates long-term body fat weight and composition. Therefore, the leptin gene could be an excellent candidate gene controlling fat deposition, carcass traits and meat quality in beef cattle. The objective of this study was to evaluate the association of 3 SNPs (A1127T and C1180T in exon 2 and C3100T in exon 3) in the bovine leptin gene with carcass and meat quality traits in Korean cattle. The C1180T SNP was associated with backfat thickness (BF) and marbling score (MS) (p<0.05). Animals with the genotype CC had higher BF than animals with TT genotype and higher MS compared with CT and TT genotypes. No significant associations were observed between the C3100T SNP and any carcass and meat quality traits analyzed. The effect of the A1127T SNP was not analyzed because the TT genotype was not detected and the AT genotype showed only 1.0% frequency. These results suggest that the C1180T SNP of the leptin gene may be useful as a genetic marker for carcass and meat quality traits in Korean cattle.
 Keywords
Leptin Gene;SNP Marker;Carcass and Meat Quality Traits;Korean Cattle;
 Language
English
 Cited by
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 References
1.
Almeida, S. E. M., E. A. Almedia, J. C. F. Moraes and T. A. Weimer. 2003. Molecular markers in the LEP gene and reproductive performance of beef cattle. J. Anim. Breed. Genet. 120:106-113. crossref(new window)

2.
Baile, C. A., M. A. Della-Fera and R. J. Martin. 2000. Regulation of metabolism and body fat mass by leptin. Annu. Rev. Nutr. 20:105-127. crossref(new window)

3.
Buchanan, F. C., C. J. Fitzsimmons, A. G. Van Kessel, T. D. Thue, D. C. W. Sim and S. M. Schmutz. 2002. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genet. Sel. Evol. 34:105-116. crossref(new window)

4.
Chung, E. R. and W. T. Kim. 2005. Association of SNP marker in IGF-I and MYF5 candidate genes with growth traits in Korean cattle. Asian-Aust. J. Anim. Sci. 18:1061-1065.

5.
Crews, D. H., J. D. Nkrumah, J. Yu and S. S. Moore. 2004. Association of single nucleotide polymorphisms in the bovine leptin gene with feedlot and carcass characteristics of crossbred steers. Can. J. Anim. Sci. 84:749-750 (Abstr.). crossref(new window)

6.
Geary, T. W., E. L. McFadin, D. M. MacNeil, E. E. Grings, R. E. Short, R. N. Funston and D. H. Keisler. 2003. Leptin as a predictor of carcass composition in beef cattle. J. Anim. Sci. 81:1-8.

7.
Gonzalez, R. R., C. Simon, P. Caballero-Campo, R. Norman, D. Chardonnens, L. Devoto and P. Bischof. 2000. Leptin and reproduction. Hum. Reprod. 6:290-300. crossref(new window)

8.
Hossner, K. L. 1998. Cellular, molecular and physiological aspects of leptin: Potential applications in animal production. Can. J. Anim. Sci. 78:463-472. crossref(new window)

9.
Ji, S., G. M. Wills, R. R. Scott and M. E. Spurlock. 1998. Partial cloning and expression of the bovine leptin gene. Anim. Biotech. 9:1-4.

10.
Konfortov, B. A., V. E. Licence and J. R. Miller. 1999. Re-sequencing of DNA from a diverse panel of cattle reveals a high level of polymorphism in both intron and exon. Mamm. Gen. 10:1142-1145. crossref(new window)

11.
Lagonigro, R., P. Wiener, F. Pilla, J. A. Woolliams and J. L. Williams. 2003. A new mutation in the coding region of the bovine leptin gene associated with feed intake. Anim. Genet. 34:371-374. crossref(new window)

12.
Lien, S. H. Sundvold, H. Klungland and D. I. Vage. 1997. Two novel polymorphisms in the bovine obesity gene (OBS). Anim. Genet. 28:238-246. crossref(new window)

13.
Madeja, Z., T. Adamowicz, A. Chmurzynska, T. Jankowski, J. Melonek, M. Switonski and T. Strabel. 2004. Effect of leptin gene polymorphisms on breeding value for milk production traits. J. Dairy Sci. 87:3925-3927. crossref(new window)

14.
Nkrumah, J. D., C. Li, J. Yu, C. Hansen, D. H. Keisler and S. S. Moore. 2005. Polymorphism in the bovine leptin gene promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit. J. Anim. Sci. 83:20-28.

15.
Pomp, D., T. Zou, A. C. Clutter and W. Barendse. 1997. Rapid communication: mapping of leptin to bovine chromosome 4 by linkage analysis of a PCR- based polymorphism. J. Anim. Sci. 75:1427.

16.
Schenkel, F. S., S. P. Miller, X. Ye, S. S. More, J. D. Nkrumah, C. Li, J. Yu, I. B. Mandell, J. W. Wilton and J. L. Williams. 2005. Association of single nucleotide polymorphisms in the leptin gene with carcass and meat quality traits of beef cattle. J. Anim. Sci. 83:2009-2020.

17.
Yoon, D. H., B. H. Cho, B. L. Park, Y. H. Choi, H. S. Cheong, H. K. Lee, E. R. Chung, I. C. Cheong and H. D. Shin. 2005. Highly polymorphic bovine leptin gene. Asian-Aust. J. Anim. Sci. 18:1548-1551.