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Effects of Dietary -Cyclodextrin on Plasma Lipid and Tissue Cholesterol Content in Swine
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 Title & Authors
Effects of Dietary -Cyclodextrin on Plasma Lipid and Tissue Cholesterol Content in Swine
Park, B.S.; Jang, A.;
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This study examined the effects of dietary -cyclodextrin () on the cholesterol of blood and tissues of swine. Thirty six male castrated swine () weighing 50 kg were randomly assigned to one of four dietary groups until their weight reached 110 kg. The groups were: basal diet without (control) and basal diets containing 1.5%, 3.0%, or 5.0% . Diets and water were offered ad libitum. No significant difference was found between treatments in terms of feeding performance measured by daily intake, daily weight gain, and feed efficiency. Addition of to the diets significantly reduced total lipid, triglyceride and total cholesterol levels in swine blood, particularly in the group receiving 5.0% , which showed decreases (p<0.05) of 21.9%, 55.6% and 27.7%, respectively. Cholesterol levels in back fat, loin, belly and ham portions of swine fed significantly differed (p<0.05) from controls, especially in the 5.0% -fed group, with reductions of 26.0%, 27.5%, 17.9% and 18.3%, respectively. These results suggested that the addition of to the diet of swine could reduce their body cholesterol by decreasing the migration of cholesterol through the blood.
Swine;-Cyclodextrin;Plasma Lipid;Triacylglyceride;Pork Cholesterol;
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Abadie, C., M. Hug, C. Kubli and N. Gains. 1994. Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces. Biochem. J. 299:725-730.

Balasubramaniam, S., J. L. Goldstein, J. R. Faust, G. Y. Brunschede and M. S. Brown. 1997. Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol ester metabolism in the adrenal gland of the rat. J. Biol. Chem. 252:1771-1782.

Bragagnolo, N. and D. B. Rodriguez. 2002. Simultaneous determination of total lipid, cholesterol and fatty acids in meat and back fat of suckling and adult pigs. Food Chem. 79:255-260. crossref(new window)

Catala I., C. Juste, N. Boehler, J. Ferezou, M. Andre, M. Riottot, C. Cutton, H. Lafront, F. Bornet and T. Corring. 2000. Cholesterol crystallization in gall-bladder bile of pigs given cholesterol-${\beta}$-cyclodextrin-enriched diets with either casein or soybean concentrate as protein sources. Br. J. Nutr. 83:411-420.

Dorado, M., G. E. M. Martin, F. Jimenez-Colmenero and T. A. Masoud. 1999. Cholesterol and fat contents of Spanish commercial pork cuts. Meat Sci. 51:321-323. crossref(new window)

Favier, M. L., C. Remesy, C. Moundras and C. Demigne. 1995. Effect of cyclodextrin on plasma lipids and cholesterol metabolism in the rat. Metabolism. 44:200-206. crossref(new window)

Ferezou, J., M. Riottot, C. Serougne, C. Cohen-solal, I. Catala, C. Alguier, M. Parguet, C. Juste, H. Lafont, D. Mathe, T. Corring and C. Lutton. 1997. Hypocholesterolemic action of ${\beta}$-cyclodextrin and its effects on cholesterol metabolism in pigs fed a cholesterol-enrich diet. J. Lipid. Res. 38:86-100.

Flourie, B., C. Molis, L. Achour, H. Dupas, C. Hatat and J. C. Rambaud. 1993. Fate of ${\beta}$-cyclodextrin in the human intestine. J. Nutr. 123:676-680.

Folch, L., M. Lees and S. H. A. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-507.

Frijlink, H. W., A. C. Eissens, N. R. Hefting, K. Poelstra, C. F. Lerk and D. K. F. Meijer. 1991. The effects of parenterally administered cyclodextrin on cholesterol levels in the rat. Pharm. Res. 8:9-16. crossref(new window)

Froming, K. H., R. Fridrich and W. Mehnert. 1993. Inclusion compounds of cholesterol and ${\beta}$-cyclodextrin. Eur. J. Pharm. Biopharm. 39:148-152.

Fukushima, M., S. Akiba and M. Nakano. 1996. Comparative hypocholesterolemic effect of six vegetable oils in cholesterol-fed rat. Lipids. 31:415-419. crossref(new window)

Grundy, S. M., E. H. Ahrens and T. A. Miettinen. 1965. Quantitative isolation and gas-liquid chromatographic analysis of total fecal bile acids. J. Lipid. Res. 6:397-410.

Horikoshi, K. 1979. Production and industrial applications of beta-cyclodextrin. Process Biochem. 14:26-30.

Hostmark, A. T., E. Lystad, A. Haung and E. Eilertsen. 1989. Plasma lipids, lipoproteins, and fecal excretion of neutral sterols and bile acids in rats fed various and high diets or low fat/high sucrose diet. J. Nutr. 119:356-363.

Hwang, J. H., S. J. Lee and H. S. Kwak. 2005. Change of properties and cholesterol lowering effect in evening primrose oil-added and cholesterol-reduced milk. Asian-Aust. J. Anim. Sci. 18:1041-1047.

Juste, C., I. Catala, M. Riottot, M. Andre, M. Parquet, B. Lyun, F. Bequet, J. Ferezou-viala, C. Serougne, N. Domingo, C. Lutton, H. Lafont and T. Corring. 1997. Inducing cholesterol precipitation from pig bile with ${\beta}$-cyclodextrin and cholesterol dietary supplementation. J. Hepatol. 26:711-721. crossref(new window)

Kim, J. J., S. H. Yu, W. M. Jeon and H. S. Kwak. 2006. The effect of evening primrose oil on chemical and blood cholesterol lowering properties of cheddar cheese. Asian-Aust. J. Anim. Sci. 19:450-458.

Kwak, H, S., C. G. Nam and J. Ahn. 2001. Low cholesterol mozzarella cheese obtained from homogenized and ${\beta}$-cyclodextrin-treated milk. Asian-Aust. J. Anim. Sci. 14:268-275.

Leaf, A. and P. C. Weber. 1988. Cardiovascular effect of n-3 fatty acid. New Engl. J. Med. 318:549-553. crossref(new window)

Mannheim, B. 1987. Methods of biochemical analysis and food analysis using test-combinations. Boehringer manheim gmbh biochemica, Sndhofer strabe manheim, W.-Germany. pp. 16-18.

Nagatomo, S. 1985. Cyclodextrins-expanding the development of their functions and applications. Chemical Economy and Engineering Review. 17:28-34.

National Research Council. 1998. Nutrient requirements of swine. 10th Edition. National Academy Press, Washington DC, USA.

Okenfull, D. G., R. J. Pearce and G. S. Sidhu. 1991. Low-cholesterol dairy product. Aust. J. Dairy Techol. 46:110-112.

Olivier, P., F. Verwaerde and A. R. Hedges. 1991. Subchronic toxicity of orally administered beta-cyclodextrin in rats. J. Am. Coll. Toxicol. 10:407-419.

Park, B. S., H. G. Kang and A. Jang. 2005. Influence of feeding ${\beta}$-cyclodextrin to laying hens on the egg production and cholesterol content of yolk. Asian-Aust. J. Anim. Sci. 18:835-840.

Park, B. S. 2003. The biological effects of ${\beta}$-cyclodextrin on antithrombotic activity and plasma lipid metabolism in rats. J. Anim. Sci. (Kor). 45:199-210 crossref(new window)

Riottot, M., P. Olivier, A. Huet, J. J. Caboche, M. Parquet, J. Khallou and C. Lutton. 1993. Hypolipidemic effects of betacyclodextrin in the hamster and in the genetically hypercholesterolemic Rico rat. Lipids. 28:181-188. crossref(new window)

Saenger, W. 1984. Structural aspects of cyclodextrins and their inclusion complexes. Incl. Compounds. 2:231-243.

SAS institute. 2000. $SAS^{\circledR}$ User's Guide : Statistics. Version 8 Edition. SAS Institute Inc., Cary, NC. USA.

Stucchi, A. F., H. M. Terpstra and R. J. Nicolos. 1995. LDL receptor activity is down-regulated similarly by a cholesterolcontained diet high in palmitic acid or high in lauric and myristic acids in cynomolgus monkeys. J. Nutr. 125:2055-2063.

Suzuki, M. and A. Sato. 1985. Nutritional significance of cyclodextrins: Indigestibility and hypolipidemic effects of ${\beta}$-cyclodextrin. J. Nutr. Sci. Vitaminol. 31:209-223.

Yen, G. C. and C. J. Chen. 2000. Effects of fractionation and the refining process of lard on cholesterol removal by ${\beta}$-cyclodextrin. J. Food Sci. 65:622-624. crossref(new window)