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Association between PCR-RFLP Polymorphisms of Five Gene Loci and Milk Traits in Chinese Holstein
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 Title & Authors
Association between PCR-RFLP Polymorphisms of Five Gene Loci and Milk Traits in Chinese Holstein
Zhang, R.F.; Chen, H.; Lei, C.Z.; Fang, X.T.; Zhang, Y.D.; Hu, S.R.; Su, L.H.;
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 Abstract
The objective of this study was to assess the association of polymorphisms in -cn, -lg, -lg 5′ flanking region, CSN1S2, and IGFBP-3 genes with milk production traits and mastitis-related traits in Chinese Holstein. Traits analyzed were 305 day standard milk yield, protein percentage, fat percentage, the ratio of fat percentage and protein percentage, pre-somatic cell count, somatic cell count, and somatic cell score, respectively. CSN1S2 locus was uninformative because only one genotype BB was found in Chinese Holstein. Allele frequencies of A and B in IGFBP-3 gene were 0.5738 and 0.4262 in Chinese Holstein population, which was different from reported Qinchuan cattle population. The genotypes of animals at IGFBP-3 locus significantly affected 305 day standard milk yield, protein percentage, and somatic cell score. The -lg genotypes had a significant effect on protein percentage and the ratio of fat percentage and protein percentage. Polymorphism in -lg 5′ flanking region was associated with 305 day standard milk yield, protein percentage, fat percentage, pre-somatic cell count, and somatic cell count. No significant associations of the polymorphism in -cn gene were observed for any trait.
 Keywords
Chinese Holstein;-lg;-cn;IGFBP-3;Milk Traits;
 Language
English
 Cited by
 References
1.
Banos, G. and G. E. Shook. 1990. Genotype by environment interaction and genetic correlations among parities for somatic cell count and milk yield. J. Dairy Sci. 73:2563. crossref(new window)

2.
Baxter, R. C. 1993. Circulating binding proteins for the insulin growth factors. Trends Endocrin Met. 4:91-96. crossref(new window)

3.
Bostein, D., R. L. White, M. Sckolnick and R. W. Dvis. 1980. Construction of genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32:317-331.

4.
Chu, M. X. and W. H. Shi. 2001. Brief discussion on mastits of dairy cattle. Chinese J. Dairy Cattle. 3:39-40.

5.
Dietz, A. B., N. D. Cohen, L. Timms and M. E. Kehrli Jr. 1997. Bovine lymphocyte antigen class II alleles as risk factors for high somatic cell counts in milk of lactating dairy cows. J. Dairy Sci. 80:406-412. crossref(new window)

6.
Ehrmann, S., H. Bartenschlager and H. Goldermann. 1997a. Polymorphism in the 5′ flanking region of the bovine Lactoglobulin encoding gene and its association with betalactoglobulin in the milk. J. Anim. Breed. Genet. 114:49-53. crossref(new window)

7.
Ford, C. A., M. B. Connett and R. J. Wilkins. 1993. $\beta$- lactoglobulin expression in bovine mammary tissue. Proc. New Zealand Soc. Anim. Prod. 53:167-169.

8.
Ge, W., M. E. Davis, H. C. Hines, K. M. Irvin and R. C. Simmen. 2001. Association of a genetic marker with blood serum insulin-like growth factor-I concentration and growth traits in Angus cattle. J. Anim. Sci. 79:1757-1762.

9.
Guo, M. C. 2005. Research on the in formatics model of population genetic variation. Dissertation for doctor degree of Northwest A & F University. China.

10.
He, F., D. X. Sun, Y. Yu, Y. C. Wang, Y. Zhang. 2006. Ass ociation between SNPs within prolactin gene and milk perf ormance traits in Holstein dairy cattle. Asian-Aust. J. Anim. Sci. 19:1384-1389.

11.
Kaminski, S. and T. Zabolewicz. 2000. Associatons between bovine beta-lactoglobulin polymorphism within coding and regulatory sequences and milk performance traits. J. Appl. Genet. 41:91-99.

12.
Kimura, M. and T. Ohta. 1973. Mutation an evolution at the molecular level. Genetics. 73(Suppl.):19-35.

13.
Kuss, A. W., J. Gogol and H. Geldermann. 2003. Association of a polymorphic AP-2 binding site in the 5' flanking region of the bovine $\beta$-lactoglobulingene with milk proteins. J. Dairy Sci. 86:2213-2218. crossref(new window)

14.
Liefers, S. C., M. F. W. te Pas, R. F. Veerkamp and T. van der Lende. 2002. Associations between leptin gene polymorphisms and production, live weight, energy balance, feed intake, and fertility in Holstein heifers. J. Dairy Sci. 85:1633-1638. crossref(new window)

15.
Liefers, S. C., R. F. Veerkamp, M. F. W. te Pas, Y. Chilliard and T. van der Lende. 2005. Genetics and physiology of leptin in periparturient dairy cows. Domest Anim. Endocrin. 29: 227-238. crossref(new window)

16.
Lin, F. Y., L. Li and Y. F. Chen. 1999. Analysis of the relationship between genotype of bovine $\kappa$-casein and milk yield. Chinese J. Anim. Sci. 35:8-9.

17.
Lum, S. L., P. Dove and J. F. Medrano. 1997. Polymorphisms of bovine $\beta$-lactoglobulin promoter and differences in the binding affinity of activator proteion-2 transcription factor. J. Dairy Sci. 80:1389-1397. crossref(new window)

18.
Macilla, H. J., H. M. Zhang and S. K. Denise. 1997. A novel polymorphism in the bovine insulin-like growth hormone factor binding protein-3 (IGFBP-3) gene. Anim. Genet. 28:375-378. crossref(new window)

19.
Mark, H. V., A. I. Bettina and N. B. Benhard. 2001. IGF-I treatment reduces hyperphagia, obesity, and hypertension in metabolic disorders induced by fetal programming. Endocrin. 142:3964-3973. crossref(new window)

20.
Nei, M. 1978. Estimation of average hetorozygosity and genetic distance from a small number of individuals. Genet. 89:583-590.

21.
Ojala, M., T. R. Famula and J. F. Medro. 1997. Effects of milk protein genotypes on the variation for milk production traits of Holstein and Jersey cows in California. J. Dairy Sci. 80:1776-1785. crossref(new window)

22.
Qiu, H. 1995. Cattle Production. Chinese Agriculture Press, Beijing, China.

23.
Ramunno, L., G. Cosenza, M. Pappalardo, E. Longobardi, D. Gallo, N. Pastore, P. Di Gregorio and A. Rando. 2001. Characterization of two new alleles at the goat CSN1S2 locus. Anim. Genet. 32:264-268. crossref(new window)

24.
Richert, M. M. and T. L. Wood. 1999. The insulin-like growth factors and IGF type I receptor during postnatal growth of the muyine mammary gland: sites of mRNA expression and potential functions. Endocrin. 140:454-461. crossref(new window)

25.
Ryniewicz, Z., L. Zwierzchowski, E. Bagnicka, J. Krzyzewski and N. Strzalkowska. 2002. Preliminary investigations on the polymorphism of defensin genes in cattle-relation with milk somatic cell count. Anim. Sci. Papers and reports. 20:125-131.

26.
Sambrook, J. and D. W. Russell. Translated by Huang Pei Tang. 2002. Molecular Cloning A Laboratory Manual. 3nd. Science Press, Beijing, China.

27.
Sharif, S., B. A. Mallard, B. N. Wilkie, J. M. Sargeant, H. M. Scott, J. C. M. Dekkers and K. E. Leslie. 1998. Association of the bovine MHC DRB3 alleles with occurrence of disease and milk somatic cell score in Canadian dairy cattle. Anim. Genet. 29:185-193. crossref(new window)

28.
Starkenburg, R. J., L. B. Hansen, M. E. Kehrli Jr. and H. Chester- Jones. 1997. Frequencies and effects of alternative DRB3. 2 alleles of BoLA for Holsteins in milk selection and control lines. J. Dairy Sci. 80:3411-3419. crossref(new window)

29.
Sun, W. B., H. Chen, X. Q. Lei, C. Z. Lei, Y. H. Zhang, R. B. Li, L. S. Zan and S. R. Hu. 2003. Polymorphisms of insulin-like growth factor binding protein 3 gene and its associations with several carcass traits in Qinchuan cattle. Hereditas (Beijing). 25:511-516.

30.
Taylor, V. J., D. E. Beever, M. J. Bryant and D. C. Wathes. 2006. Pre-pubertal measurements of the somatotrophic axis as predictors of milk production in Holstein-Friesian dairy cows. Domest. Anim. Endocrin. 31:1-18. crossref(new window)

31.
Vaiman, D., D. Mercier, K. Moazami-Goudarzi, A. Eggen, R. Ciampolini, A. Lepingle, R. Velmala, J. Kaukinen, S. L. Varvio, P. Martin, H. Leveziel and G. Guerin. 1994. A set of 99 cattle microsatellites characterization synteny mapping and polymorphism. Mamm. Genome. 5:288-297. crossref(new window)

32.
Wagner, V. A., T. A. Schild and H. Geldermann. 1994. DNA variants within the 5′-flanking region of milk protein-encoding genes. II. The $\beta$-lactoglobulin-encoding gene. Theor. Appl. Genet. 89:121-126.

33.
Yahyaoui, M. H., A. Angiolillo, F. Pilla, A. Sanchez and J. M. Folch. 2003. Characterization and genotyping of the Caprine $\kappa$-casein variants. J. Dairy Sci. 86:2715-2720. crossref(new window)

34.
Yahyaoui, M. H., R. N. Pena, A. Sanchez and J. M. Folch. 2000. Rapid communica tion: Polymorphism in the goat $\beta$- lactoglobulin proximal promotor region. J. Anim. Sci. 78:1100-1101.

35.
Zhao, C. J., Y. Zhang and N. Li. 1999. Research on the relationship between molecular genetic polymorphism of milk protein and dairy traits in Chinese Holsteins. J. Yellow Cattle Sci. 25:13-15.

36.
Zhou, L., Y. Y. Yang, Z. H. Li, L. J. Kong, G. D. Xing, H. S. Di and G. L. Wang. 2006. Detection and characterization of PCRSSCP markers of the bovine lactoferrin gene for clinical mastitis. Asian-Aust. J. Anim. Sci. 19:1399-1403.

37.
Zhu, M. X. and Y. Zhang. 2000. Analysis of correlation between milk protein polymorphisms and dairy performance of Chinese Holstein in Beijing. Chinese J. Anim. Sci. 36:3-6.