Advanced SearchSearch Tips
Association of SNP Marker in the Thyroglobulin Gene with Carcass and Meat Quality Traits in Korean Cattle
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Association of SNP Marker in the Thyroglobulin Gene with Carcass and Meat Quality Traits in Korean Cattle
Shin, S.C.; Chung, E.R.;
  PDF(new window)
Thyroid hormones play an important role in regulating metabolism and can affect homeostasis of fat depots. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. The SNP occurs in the 5' promoter region of the TG gene and is widely used in marker assisted selection (MAS) programs to improve the predictability of marbling level and eating quality in beef cattle. In this study, we identified three SNPs at the 5' promoter region of the TG gene in Korean cattle. Of the three SNPs identified in TG gene, the C257T and A335G were previously unreported new SNPs. The sequence data were submitted to GenBank (GenBank accession number: AY615525). The previously reported C422T SNP showed three genotypes, CC, CT and TT, by digestion with the restriction enzyme MflI using the PCR-RFLP method. A new allelic variant corresponding to the CT and AG mutations at positions 257 and 335, respectively, could be detected by the SSCP analysis. The gene-specific SNP marker association analysis indicated that the C422T SNP marker was significantly associated (p<0.05) with marbling score. Animals with the CC and CT genotypes had higher marbling score than those with the TT genotype. Results from this study suggest that TG gene-specific SNP may be a useful marker for meat quality traits in future MAS programs in Korean cattle.
TG Gene;SNP Marker;Marbling Score;Korean Cattle;
 Cited by
Identification of a Novel SNP Associated with Meat Quality in C/EBP${\alpha}$ Gene of Korean Cattle,;;;

아세아태평양축산학회지, 2007. vol.20. 4, pp.466-470 crossref(new window)
SNP Detection of Carboxypeptidase E Gene and Its Association with Meat Quality and Carcass Traits in Korean Cattle,;;

아세아태평양축산학회지, 2007. vol.20. 3, pp.328-333 crossref(new window)
Molecular Cloning and Characterization of Bovine HMGA1 Gene,;;;;;;;;

아세아태평양축산학회지, 2007. vol.20. 11, pp.1662-1669 crossref(new window)
소의 CSRP3, APOBEC2, Caveolin 유전자들의 단일염기다형 분석,삼술부이얀;유성란;김관석;윤두학;박응우;전진태;이준헌;

Journal of Animal Science and Technology, 2007. vol.49. 6, pp.719-728 crossref(new window)
DNA Polymorphisms in SREBF1 and FASN Genes Affect Fatty Acid Composition in Korean Cattle (Hanwoo),;;;;;;;;;

아세아태평양축산학회지, 2009. vol.22. 6, pp.765-773 crossref(new window)
Detection of Quantitative Trait Loci for Growth and Carcass Traits on BTA6 in a Hanwoo Population,;;;;;;

아세아태평양축산학회지, 2010. vol.23. 3, pp.287-291 crossref(new window)
소의 도체, 육질형질과 CSRP3, ACOX1 유전자들과의 상관관계,이종관;조용민;이준헌;

농업과학연구, 2010. vol.37. 2, pp.231-238
한우 14번 염색체 QTL 영역내 Fatty acid binding protein 5 유전자의 다형성과 도체 및 육질 형질과의 관련성 분석,허강녕;김남국;이승환;김남영;전진태;박응우;오성종;김태헌;성환후;윤두학;

Journal of Animal Science and Technology, 2011. vol.53. 4, pp.311-317 crossref(new window)
Application of Linkage Disequilibrium Mapping Methods to Detect QTL for Carcass Quality on Chromosome 6 Using a High Density SNP Map in Hanwoo,;;;;

아세아태평양축산학회지, 2011. vol.24. 4, pp.457-462 crossref(new window)
한우에서 TG와 EDG1 유전자의 단일염기다형 확인 및 도체형질과의 연관성 분석,카야디;디아 마하라니;유승희;이승환;이준헌;

농업과학연구, 2012. vol.39. 3, pp.349-355 crossref(new window)
Association of polymorphisms in the leptin and thyroglobulin genes with meat quality and carcass traits in beef cattle, Revista Brasileira de Zootecnia, 2012, 41, 10, 2162  crossref(new windwow)
Exploring evidence of positive selection reveals genetic basis of meat quality traits in Berkshire pigs through whole genome sequencing, BMC Genetics, 2015, 16, 1  crossref(new windwow)
Effect of thyroglobulin gene polymorphisms on growth, carcass composition and meat quality traits in Chinese beef cattle, Molecular Biology Reports, 2015, 42, 9, 1403  crossref(new windwow)
Ailhaud, G., P. Grimaldi and R. Negrel. 1992. Cellular and molecular aspects of adipose tissue development. An. Rev. Nutr. 12:207-233. crossref(new window)

Barendse, W. 1999. Assessing lipid metabolism. International patent application PCT/AU98/00882, international patent publication WO 99/23248.

Barendse, W., R. Bunch, M. Thomas, S. Armitage, S. Baud and N. Donaldson. 2001. The TG5 DNA marker test for marbling capacity in Australian feedlot cattle. Available at: 02/session6/6a.html. accessed: March 9, 2003

Burrell, D. N., G. H. D. Moser, J. Hetzel, Y .S. S. Mizoguchi, T. K. S. Hirano, Y. S. K. Z. Sugimoto and K. R. Mengersen. 2004. Meta analysis confirms associations of the TG5 thyroglobulin polymorphism with marbling in beef cattle. 29th International Conference on Animal Genetics ISAG 2004/TOKYO P.135.

Casas, E., S. D. Shackelford, J. W. Keele, R. T. Stone, S. M. Kappes and M. Koohmaraie. 2000. Quantitative trait loci affecting growth and carcass composition of cattle segregating alternate forms of myostatin. J. Anim. Sci. 78:560-569.

Casas, E., S. N. White, D. G. Riley, T. P. L. Smith, R. A. Brenneman, T. A. Olson, D. D. Johnson, S. W. Coleman, G.. L. Bennett and C. C. Chase, Jr. 2005. Assessment of single nucleotide polymorphisms in genes residing on chromosomes 14 and 29 for association with carcass composition trait in Bos indicus cattle. J. Anim. Sci. 83:13-19.

Chung, E. R. and W. T. Kim. 2005. Association of SNP marker in IGF-I and MYF5 candidate genes with growth traits in Korean cattle. Asian-Aust. J. Anim. Sci. 18:1061-1065.

Darimont, C., D. Gaillard, G. Aihaud and R. Negrel. 1993. Terminal differentiation of mouse preadipocyte cells: adipogenisis and antimitogenic role of triiodothyronine. Mol. Cell Endocrinol. 98:67-73. crossref(new window)

De, S., M. D. MacNeil, X. L. Wu, J. J. Michal, Q. J. Xiao, M. D. Garcia, K. B. Griffin, C. T. Gaskins, J. J. Reeves, J. R. Busboom, R. W. Wright Jr. and Z. Jiang. 2004. Detection of quantitative trait loci for marbling and backfat in Wagyu $\times$Limousin F2 crosses using a candidate gene approach. In: Proceedings of the Western Section, American Society of Animal Science, 55:95-98.

Ge, W., M. E. Davis, H. C. Hines, K. M. Irvin and R. C. M. Simmen. 2003. Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle. J. Anim. Sci. 81:641-648.

Grisart, B., W. Coppieters, F. Farnir, L. Karim, C. Ford, P. Berzi, N. Cambisano, M. Mni, S. Reid, P. Simon, R. Spelman, M. Georges and R. Snell. 2001. Positional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome. Res. 12:222-231. crossref(new window)

Mears, G. J., P. S. Mir, D. R. C. Bailey and S. D. M. Jones. 2001. Effect of Wagyu genetics on marbling, backfat, and circulating hormones in cattle. Can. J. Anim. Sci. 81:6573.

Meuwissen, T. H. E. and M. E. Goddard. 1996. The use of marker haplotypes in animal breeding schemes. Genet. Sel. Evol. 28:161-177. crossref(new window)

Moore, S. S., C. Li, J. Basarab, W. M. Snelling, J. Kneeland, B. Murdoch, C. Hansen and B. Benkel. 2003. Fine mapping of quantitative trait loci and assessment of positional candidate genes for backfat on bovine chromosome14 in a commercial line of Bos Taurus. J. Anim. Sci. 81:1919-1925.

Rincker, C. B., N. A. Pyatt, L. L. Berger and D. B. Faulkner. 2006. Relationship among GeneSTAR marbling marker, intramuscular fat deposition, and expected progeny differences in early weaned Simmental steers. J. Anim. Sci. 84:686-693.

Smas, C. M. and H. S. Sul. 1995. Control of adipocyte differentiation. Biochem. J. 309:697-710.

Stone, R. T., E. Casas, T. P. Smith, J. W. Keele, G. Harhay, G. L. Bennett, M. Koohmaraie, T. L. Wheeler, S. D. Shackelford and W. M. Snelling. 2005. Identification of genetic markers for fat deposition and meat tenderness on bovine chromosome 5: Development of a low-density single nucleotide polymorphism map. J. Anim. Sci. 83:2280-2288.

Thaller, G., C. Kuhn, A. Winter, G.. Ewald, O. Bellmann, J. Wegner, H. Zuhlke and R. Fries. 2003. DGAT1, a new positional and functional candidate gene for intramuscular fat deposition in cattle. Anim. Genet. 34:354-357. crossref(new window)