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Peroxisome Proliferator-activated Receptor Is Involved in Weaning to Estrus of Primiparous Sows by Regulating the Expression of Hormone Genes in Hypothalamus-pituitary-ovary Axis
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 Title & Authors
Peroxisome Proliferator-activated Receptor Is Involved in Weaning to Estrus of Primiparous Sows by Regulating the Expression of Hormone Genes in Hypothalamus-pituitary-ovary Axis
Kong, L.J.; Wang, A.G.; Fu, J.L.; Lai, CH.H.; Wang, X.F.; Lin, H.CH.;
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The objective of this study was to determine whether peroxisome proliferator-activated receptor (PPAR is involved in the regulation of weaning to estrus of primiparous sows. Twelve sows composed of 6 groups of 2 full-sibs in a similar age (325.2 d), body weight (BW; 152.4 kg) and backfat thickness (BFT; 27.0 mm) at start of lactation, were allocated to accept 31 MJ (restricted group, R-group) or 53 MJ (control group, C-group) DE/d treatment, respectively. The experimental results indicated that the low energy intake resulted in excessive losses of BW and BFT during lactation in R-group sows, which may be related to decrease of serum 15-deoxy--prostaglandin (15d-), a ligand of PPAR The obvious peak and the frequency of LH, FSH and estradiol () were only observed in C-group sows. Except for at d 1 and 2, serum FSH, LH and concentrations in R-group were lower than those in C-group sows after weaning. However, the serum progesterone () level in R-group sows was always more than that in C-group. The expression abundances of PPARand GnRH receptor (GnRH-R) in pituitary, FSH receptor (FSH-R), LH receptor (LH-R), estrogen receptor (ES-R) and aromatase in ovary of anestrous sows were lower than those of estrous sows. Neither the BFT nor the BW was associated with the mRNA abundance of PPARin hypothalamus during lactation. Expressions of PPARin pituitary and ovary were affected evidently by the BFT changes and only by the loss of BW of sows during and after lactation. Furthermore, PPARmRNA level in ovary was significantly related to the expression abundances of GnRH-R, FSH-R, ES-R and aromatase, and GnRH-R was obviously associated with PPARexpression in pituitary. However, PPARexpression in hypothalamus likely has no effects on these genes expression and no obvious difference for all sows. Not serum or alone but the ratios of to and 15d- to , and serum FSH and LH were evidently related to PPARexpression in pituitary and ovary. It is concluded that PPARis associated with body conditions, reproduction hormones and their receptor expression, which affected the functions of pituitary and ovary and ultimately the estrus after weaning of primiparous sows.
Primiparous Sows;Body Condition;Hypothalamus-pituitary-ovary Axis;Estrus;Peroxisome Proliferator-activated Receptor γ;Hormone Receptor;
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