Advanced SearchSearch Tips
DdeI Polymorphism in Coding Region of Goat POU1F1 Gene and Its Association with Production Traits
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
DdeI Polymorphism in Coding Region of Goat POU1F1 Gene and Its Association with Production Traits
Lan, X.Y.; Pan, C.Y.; Chen, H.; Lei, C.Z.; Hua, L.S.; Yang, X.B.; Qiu, G.Y.; Zhang, R.F.; Lun, Y.Z.;
  PDF(new window)
POU1F1 is a positive regulator for GH, PRL and TSH and its mutations associate with production traits in ruminant animals. We described a DdeI PCR-RFLP method for detecting a silent allele in the goat POU1F1 gene: TCT (241Ser)>TCG (241Ser). Frequencies of allele varied from 0.600 to 1.000 in Chinese 801 goats. Significant associations of DdeI polymorphism with production traits were found in milk yield (*p<0.05), litter size (*p<0.05) and one-year-old weight (*p<0.05) between different genotypes. Individuals with genotype had a superior performances when compared to those with genotype (*p<0.05). Hence, the POU1F1 gene was suggested to the potential candidate gene for superior milk performance, reproduction trait and weight trait. Genotype , characterized by a DdeI PCR-RFLP detection, was recommended to geneticists and breeders as a molecular marker for better performance in the goat industry.
Goat;POU1F1 Gene;Polymorphism;Association;
 Cited by
A New Single Nucleotide Polymorphism in the IGF-I Gene and Its Association with Growth Traits in the Nanjiang Huang Goat,;;;;;;

아세아태평양축산학회지, 2008. vol.21. 8, pp.1073-1079 crossref(new window)
Archetti, M. 2004. Codon usage bias and mutation constraints reduce the level of error minimization of the genetic code. J. Mol. Evol. 59(2):258-266 crossref(new window)

Bastos, E., I. Santos, I. H. Parentier, J. L. Castrillo, A. Cravador, M. Guedes-Pinto and R. Renaville. 2006. Ovis aries POU1F1 gene: cloning, characterization and polymorphism analysis. Genet. 126:303-314 crossref(new window)

Boyazoglu, J., I. Hatziminaoglou and P. Morand-Fehr. 2005. The role of the goat in society: Past, present and perspectives for the future. Small Rumin. Res. 60:13-23 crossref(new window)

Coghlan, A. and K. H. Wolfe. 2000. Relationship of codon bias to mRNA concentration and protein length in Saccharomyces cerevisiae. Yeast, 16(12):1131-1145 crossref(new window)

Dubeuf, J. P., P. Morand-Fehr, Rubino and R. Situation. 2004. changes and future of goat industry around the world. Small Rumin. Res. 51:165-173 crossref(new window)

Esley, M., J. Heizer, Douglas W. Raiford, Michael L. Raymer, Travis E. Doom, Robert V. Miller and Dan E. Krane. 2006. Amino Acid Cost and Codon-Usage Biases in 6 Prokaryotic Genomes: A Whole-Genome Analysis. Mole. Biol. Evol. 2399:1670-1680

Eyre-Walker, A. 1996. Synonymous codon bias is related to gene length in Escherichia coli: selection for translational accuracy? Mole. Biol. Evol. 13:864-872

Jacobson, E. M., P. Li, A. Leon-del-Pio, M. G. Rosenfeld and A. K. Aggarwa. 1997. Structure of Pit-1 POU domain bound to DNA as dimer: unexpected arrangement and flexibility. Genes. Dev. 11:198-212 crossref(new window)

Kim, J. Y., D. H. Yoon, B. L. Park, L. H. Kim, K. J. Na, J. G. Choi, C. Y. Cho, H. K. Lee, E. R. Chung, B. C. Sang, I. J. Cheong, S. J. Oh and H. D. Shin. 2005. Identification of Novel SNPs in Bovine Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Gene. Asian-Aust. J. Anim. Sci. 18(1):3-7

Kurland, C. G. 1991. Codon bias and gene expression FEBS Lett. 285(2):65-69

Lavner, Y. and D. Kotlar. 2005. Codon bias as a factor in regulating expression via translation rate in the human genome. Gene. 345:127-138 crossref(new window)

Li, J. T., A. H. Wang, P. Chen, H. B. Li, C. S. Zhang and L. X. Du. 2006. Relationship between the Polymorphisms of 5'Regulation Region of Prolactin Gene and Milk Traits in Chinese Holstein Dairy Cows. Asian-Aust. J. Anim. Sci. 19(4):459-462

Liu, H., X. H. Wang, Y. F. Liu, X. B. Zhao, N. Li and C. X. Wu. 2006. Codon frequency influencing laying performance: Evidence from 3 SNP in chicken prolactin gene, 10(1):196-198 (Abstr.)

Li, S., III E. B. Crenshaw, E. J. Rawson, D. M. Simmons, L. W. Swanson and M. G. Rosenfeld. 1990. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1. Nature, 347:528-533 crossref(new window)

Pfaffle, R. W., G. E. DiMattia, J. Parks, M. Brown, J. M. Wit, M. Jansen, N. H. Van der, J. L. Van den Brande, M. G. Rosenfel, H. A. Ingraham. 1992. Mutation of the POU-specific domain of Pit-1 and hypopituitarismwithout pituitary hypoplasia. Sci. 257:1118-1121 crossref(new window)

Renaville, R., N. Gengler, E. Vrench, A. Prandi, S. Massart, C. Corradini, C. Bertozzi, F. Mortiaux, A. Burny and D. Portetelle. 1997a. Pit-1 gene polymorphism, milk yield, and conformation traits for Italian Holstein-Friesian bulls. J. Dairy Sci. 80:3431-3438 crossref(new window)

Renaville, R., N. Gengler, I. Parmentier, F. Mortiaux, S. Massart, C. Bertozzi, A. Burny and D. Portetelle. 1997b. Pit-1 gene HinfI RFLP and growth traits in double-muscled Belgian Blue Cattle. J. Anim. Sci. 75 (Suppl. 1):146 (Abstr.)

Reynau, R., A. Saveanu, A. Barlier, A. Enjalbert and T. Brue. 2004. Pituitary hormone deficiencies due to transcription factor gene alterations. Growth Hormone & IGF Research, 14(6):442-448

Sambrook, J. and D. W. Russell. 2001. Molecular Cloning: A Laboratory Manual, vol. 3, third ed. Cold Spring Harbor Laboratory Press, New York

Stancekov, K., D. Vasicek, D. Peskovicov, J. Bull and A. Kubek. 1999. Effect of genetic variability of the porcine pituitaryspecific transcription factor (PIT-1) on carcass traits in pigs. Anim. Genet. 30:313-315 crossref(new window)

Sun, H. S., L. L. Andersona, T. P. Yu, K. S. Kim, J. Klind and C. K. Tuggle. 2002. Neonatal Meishan pigs show POU1F1 genotype effects on plasma GH and PRL concentration. Anim. Rep. Sci. 69:223-237 crossref(new window)

Woollard, J., C. K. Tuggle and. F. A. Ponce de Leon. 2000. Rapid communication: Localization of POU1F1 to bovine, ovine, and caprine 1q21-22. J. Anim. Sci. 78:242-243

Yu, T. P., C. K. Tuggle, C. B. Schmitz and M. F. Rothschild. 1995. Association of PIT1 polymorphisms with growth and carcass traits in pigs. J. Anim. Sci. 73:1282-1288

Zhao, Q., M. E. Davis and H. C. Hines. 2004. Associations of polymorphisms in the Pit-1 gene with growth and carcass traits in Angus beef cattle. J. Anim. Sci. 82(8):2229-2233

Zhou, G. L., Q. Zhu, H. G. Jin and S. L. Guo. 2006. Genetic Variation of Growth Hormone Gene and Its Relationship with Milk Production Traits in China Holstein Cows. Asian-Aust. J. Anim. Sci. 19(3):315-318

Zhou, L., Y. Y. Yang, Z. H. Li, L. J. Kong, G. D. Xing, H. S. Di and G. L. Wang. 2006. Detection and Characterization of PCRSSCP Markers of the Bovine Lactoferrin Gene for Clinical Mastitis. Asian-Aust. J. Anim. Sci. 19(10):1399-1403