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DdeI Polymorphism in Coding Region of Goat POU1F1 Gene and Its Association with Production Traits
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 Title & Authors
DdeI Polymorphism in Coding Region of Goat POU1F1 Gene and Its Association with Production Traits
Lan, X.Y.; Pan, C.Y.; Chen, H.; Lei, C.Z.; Hua, L.S.; Yang, X.B.; Qiu, G.Y.; Zhang, R.F.; Lun, Y.Z.;
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POU1F1 is a positive regulator for GH, PRL and TSH and its mutations associate with production traits in ruminant animals. We described a DdeI PCR-RFLP method for detecting a silent allele in the goat POU1F1 gene: TCT (241Ser)>TCG (241Ser). Frequencies of allele varied from 0.600 to 1.000 in Chinese 801 goats. Significant associations of DdeI polymorphism with production traits were found in milk yield (*p<0.05), litter size (*p<0.05) and one-year-old weight (*p<0.05) between different genotypes. Individuals with genotype had a superior performances when compared to those with genotype (*p<0.05). Hence, the POU1F1 gene was suggested to the potential candidate gene for superior milk performance, reproduction trait and weight trait. Genotype , characterized by a DdeI PCR-RFLP detection, was recommended to geneticists and breeders as a molecular marker for better performance in the goat industry.
Goat;POU1F1 Gene;Polymorphism;Association;
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