Advanced SearchSearch Tips
Dietary Supplementation with Acanthopanax senticosus Extract Modulates Cellular and Humoral Immunity in Weaned Piglets
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Dietary Supplementation with Acanthopanax senticosus Extract Modulates Cellular and Humoral Immunity in Weaned Piglets
Kong, Xiangfeng; Yin, Yulong; Wu, Guoyao; Liu, Hejun; Yin, Fugui; Li, Tiejun; Huang, Ruilin; Ruan, Zheng; Xiong, Hua; Deng, Zeyuan; Xie, Mingyong; Liao, Yiping; Kim, Sungwoo;
  PDF(new window)
This study was conducted to test the hypothesis that dietary supplementation with an herbal extract of Acanthopanax senticosus (AS) enhances the immune response in weaned piglets. Sixty piglets weaned at 21 days of age were randomly assigned to 3 treatment groups representing the addition of 0 or 1 g/kg of the AS extract or 0.2 g/kg of colistin (an antibiotic) to maize- and soybean meal-based diets (n = 20 per group). On days 7, 14 and 28 after initiation of the addition, total and differential counts of leucocytes, proliferating activity of peripheral lymphocytes, serum levels of immunoglobulins (Ig) and cytokines and the spleen index were determined. The AS extract decreased (p<0.05) the number of neutrophils on days 7 and 28 in comparison with the control group and reduced (p<0.05) serum interleukin- level on day 28 compared with the other 2 groups. Dietary supplementation with the AS extract increased (p<0.05) the lymphocyte/leukocyte ratio on day 28 compared with the control group and increased the proliferating activity of lymphocytes on days 14 and 28 compared with the other 2 groups. The AS extract increased (p<0.05) the serum content of IgG on day 7 and of IgG and IgM on day 28 compared with the other 2 groups, as well as increasing the serum content of tumor necrosis factor on day 7 and spleen index on days 7 and 28 compared with the control group. Collectively, these findings suggest that the AS extract as a dietary additive enhances the cellular and humoral immune responses of weaned piglets by modulating the production of immunocytes, cytokines and antibodies.
Dietary Additive;Acanthopanax Senticosus Extract;Immunity;Weaned Piglets;
 Cited by
True Digestibility of Phosphorus in Different Resources of Feed Ingredients in Growing Pigs,;;;;;;;;;;;

아세아태평양축산학회지, 2008. vol.21. 1, pp.107-119 crossref(new window)
Dietary Bovine Colostrum Increases Villus Height and Decreases Small Intestine Weight in Early-weaned Pigs,;;;;;

아세아태평양축산학회지, 2008. vol.21. 4, pp.567-573 crossref(new window)
Effects of Achyranthes Bidentata Polysaccharide on Growth Performance, Immunological, Adrenal, and Somatotropic Responses of Weaned Pigs Challenged with Escherichia coli Lipopolysaccharide,;;;;;;;;;;;;;

아세아태평양축산학회지, 2008. vol.21. 8, pp.1189-1195 crossref(new window)
Effect of Galacto-mannan-oligosaccharides or Chitosan Supplementation on Cytoimmunity and Humoral Immunity in Early-weaned Piglets,;;;;;;;;;;;;

아세아태평양축산학회지, 2008. vol.21. 5, pp.723-731 crossref(new window)
Dietary Supplementation with Acanthopanax senticosus Extract Modulates Gut Microflora in Weaned Piglets,;;;;;;;;;;;;;;

아세아태평양축산학회지, 2008. vol.21. 9, pp.1330-1338 crossref(new window)
Effects of Acanthopanax senticosus Polysaccharide Supplementation on Growth Performance, Immunity, Blood Parameters and Expression of Pro-inflammatory Cytokines Genes in Challenged Weaned Piglets,;;;;;;

아세아태평양축산학회지, 2014. vol.27. 7, pp.1035-1043 crossref(new window)
The effect of dietary addition of a polysaccharide from Atractylodes macrophala Koidz on growth performance, immunoglobulin concentration and IL-1β expression in weaned piglets, The Journal of Agricultural Science, 2009, 147, 05, 625  crossref(new windwow)
polysaccharide enhances immune response in weaned piglets, Immunopharmacology and Immunotoxicology, 2009, 31, 2, 253  crossref(new windwow)
Effects of <i>Acanthopanax senticosus</i> Polysaccharide Supplementation on Growth Performance, Immunity, Blood Parameters and Expression of Pro-inflammatory Cytokines Genes in Challenged Weaned Piglets, Asian-Australasian Journal of Animal Sciences, 2014, 27, 7, 1035  crossref(new windwow)
Effects of antibacterial peptide on humoral immunity in weaned piglets, Food and Agricultural Immunology, 2015, 26, 5, 682  crossref(new windwow)
Effects of dietary nutrient levels on microbial community composition and diversity in the ileal contents of pregnant Huanjiang mini-pigs, PLOS ONE, 2017, 12, 2, e0172086  crossref(new windwow)
on gastrointestinal tract development in calves, Animal Science Journal, 2017, 88, 9, 1321  crossref(new windwow)
Balaji, R., K. J. Wright, C. M. Hill, S. S. Dritz, E. L. Knoppel and J. E. Minton. 2000. Acute phase responses of pigs challenged orally with Salmonella typhimurium. J. Anim. Sci. 78:1885-1891 crossref(new window)

Beers-Schreurs, H. M. G., L. Vellenga, T. H. Wensing and H. J. Breukink. 1992. The pathogenesis of the post-weaning syndrome in weaned piglets: a review. Vet. Quart. 14:29-34

Bemelmans, M. H. A., L. J. H. Van Tits and W. A. Buurman. 1996. Tumor necrosis factor: function, release and clearance. Crit. Rev. Immunol. 16:1-11

Bogdan Petrunov, Snejina Marinova, Roumiana Markova, Plamen Nenkov, Sasha Nikolaeva, Maria Nikolova, Hristo Taskov and Jordan Cvetanov. 2006. Cellular and humoral systemic and mucosal immune responses stimulated in volunteers by an oral polybacterial immunomodulator "Dentavax". Int. Immunopharmacol. 6(7):1181-1193 crossref(new window)

Burg, N. D. and M. H. Pillinger. 2001. The neutrophil: function and regulation in innate and humoral immunity. Clin. Immunol. 99:7-17 crossref(new window)

Cai, S. F., H. Y. Jiang and Y. P. Ou. 2000. Study on organic acid content in different processed products of fructus crataegi. Chinese Traditional Patent Med. 22(12):841-842

Clapperton, M., S. C. Bishop and E. J. Glass. 2005. Innate immune traits differ between Meishan and Large White pigs. Vet. Immunol. Immunopathol. 104:131-144 crossref(new window)

Deng, D., L. Huang, T. J. Li, G. Y. Wu, M. Y. Xie, Z. R. Tang, P. Kang, Y. M. Zhang, M. Z. Fan, X. F. Kong, Z. Ruan, H. Xiong, Z. Y. Deng and Y.-L. Yin. 2007a. Nitrogen balance in barrows fed low-protein diets supplemented with essential amino acids. Livest. Sci. 109:220-223 crossref(new window)

Deng, D., Ai-Ke Li, W. Y. Chu, R. L. Huang, T. J. Li, X. F. Kong, Z. J. Liu, G. Y. Wu, Y. M. Zhang and Y. L. Yin. 2007b. Growth performance and metabolic responses in barrows fed lowprotein diets supplemented with essential amino acids. Livest. Sci. 109:224-227 crossref(new window)

Doherty, J. F., M. H. N. Golden, D. G. Remick and G. E. Griffin. 1994. Production of interleukin-6 and tumour necrosis factoralpha in vitro is reduced in whole blood of severely malnourished children. Clin. Sci. 86:347-351

Dunkley, M., R. Pabst and A. Cripps. 1995. An important role for intestinally derived T cells in respiratory disease. Immunol. Today. 16:231-236 crossref(new window)

Fan, M. Z., T. J. Li, Y. L. Yin, R. J. Fang, Z. Y. Tang, Z. P. Hou, R. L. Huang, Z. Y. Deng, H. Y. Zhong, R. G. Zhang, J. Zhang, B. Wang and H. Schulze. 2005. Effect of phytase supplementation with two levels of phosphorus diets on ileal and faecal digestibilities of nutrients and phosphorus, calcium, nitrogen and energy balances in growing pigs. Anim. Sci. 81:67-75

Fujikawa, T., A. Yamaguchi, I. Morita, H. Takeda and S. Nishibe. 1996. Protective effects of Acanthopanax senticosus harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol. Pharmaceut. Bull. 19:1227-1230

Fujikawa, T., H. Soya, H. Hibasami, H. Kawashima, H. Takeda, S. Nishibe and K. Nakashima. 2002. Effect of Acanthopanax senticosus harms on biogenic monoamine levels in the rat brain. Phytother. Res. 16:474-478 crossref(new window)

Greiner, L. L., T. S. Stahly and T. J. Stabel. 2000. Quantitative relationship of systemic virus concentration on growth and immune response in pigs. J. Anim. Sci. 78:2690-2695

Gross, W. B. and H. S. Siegel. 1983. Evaluation of the heterophil/lymphocyte ratio and a measure of stress in chickens. Avian disease. 27:972-979 crossref(new window)

Han, S. B., Y. D. Yoon, H. J. Ahn, H. S. Lee, C. W. Lee, W. K. Yoon, S. K. Park and H. M. Kim. 2003. Toll-like receptormediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus. Int. Immunopharmacol. 3(9):1301-1312 crossref(new window)

Herskin, M. S. and K. H. Jensen. 2002. Effects of open field testing and associated handling. V. Handling alone on the adrenocortical reactivity of piglets around weaning. Anim. Sci. 74:485-491

Huang, R. -L., Y.-L. Yin, G.-Y. Wu, Y.-G. Zhang, T.-J. Li, L.-L. Li, M.-X. Li, Z.-R. Tang, J. Zhang, B. Wang, J.-H. He and X.-Z. Nie. 2005. Effect of Dietary Oligochitosan Supplementation on Ileal Digestibility of Nutrients and Performance in Broilers. Poult. Sci. 84:1383-1388

Huang, R. L., Y. L. Yin, M. X. Li, G. Y. Wu, T. J. Li, L. L. Li, C. B. Yang, J. Zhang, B. Wang, Z. Y. Deng, Y. G. Zhang, Z. R. Tang, P. Kang and Y. M. Guo. 2007. Dietary oligochitosan supplementation enhances immune status of broilers. J. Sci. Food Agric. 87:153-159 crossref(new window)

Huang, X. D., L. Kong, X. Li, X. G. Chen, M. Guo and H. F. Zou. 2004. Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines. J. Chromatography B. 812:71-84

Johnson, R. W. 1998. Immune and endocrine regulation of food intake in sick animals. Dom. Anim. Endocrinol. 15:309-319 crossref(new window)

Jung, H. J., H. J. Park, R. G. Kim, K. M. Shin, J. Ha, J. W. Choi, H. J. Kim, Y. S. Lee and K. T. Lee. 2003. In vivo antiinflammatory and antinociceptive effects of liriodendrin isolated from the stem bar of Acanthopanax senticosus. Planta. Medica. 69:610-616 crossref(new window)

Kang, J. S., P. T. Linh, X. F. Cai, H. S. Kim, J. J. Lee and Y. H. Kim. 2001. Quantitative determination of eleutheroside B and E from Acanthopanax species by high performance liquid chromatography. Arch. Pharm. Res. 24(5):407-411 crossref(new window)

Kelley, K. W., R. W. Johnson and R. Dantzer. 1994. Immunology discovers physiology. Vet. Immunol. Immunopathol. 43:157-165 crossref(new window)

King, R. H., J. L. Dividich and F. R. Dunshea. 1999. Lactation and Neonatal Growth. In: (Ed. I. Kyriazakis) A Quantitative Biology of the Pig. CABI publishing, CAB International, Wallingford, UK. pp. 155-80

Kong, X. F., Y. L. Hu, R. Rui, D. Y. Wang and X. R. Li. 2004. Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. Int. Immunopharmacol. 4:975-982 crossref(new window)

Kong, X.-F., G.-Y. Wu, Y.-L. Yin, H.-J. Liu, F.-G. Yin, T.-J. Li, R.- L. Huang, P. Kang, F.-F. Xing, M.-Z. Fan, C.-B. Yang and Q.- H. He. 2007a. Dietary supplementation with Chinese herbal ultra-fine 3 powder enhances cellular and humorl immunity in early weaned piglets. Livest. Sci. 108:94-98 crossref(new window)

Kong, X. F., G. Y. Wu, Y. P. Liao, Z. P. Hou, H. J. Liu, F. G. Yin, T. J. Li, R. L. Huang, Y. M. Zhang, D. Deng, P. Kang, R. X. Wang, Z. Y. Tang, C. B. Yang, Z. Y. Deng, H. Xiong, W.-Y. Chu, Z. Yuan, M. Y. Xie and Y. L. Yin. 2007b. Effects of Chinese herbal ultra-fine powder as a dietary additive on growth performance, serum metabolites and intestinal health in early-weaned piglets. Livest. Sci. 108:272-275 crossref(new window)

Kusnecov, A. W. and A. Rossi-George. 2002. Stressor-induced modulation of immune function: a review of acute chronic effects in animals. Acta Neuropsychiatr. 14:279 crossref(new window)

Li, T. J., Y. L. Yin, Y. L. Huang, X. W. Tan, Y. F. Chen and H. Y. Zhong. 2003. Effect of dietary fibre on the flow of bacterial N and bacterial amino acid at the terminal ileum of pig. Acta Vet. Zootech. Sinica. 34:239-245

Li, T.-J., Y.-L. Yin, S.-Y. Bin, R.-L. Huang, Q.-Z. Dai, P. Zhang, Z.-P. Hou and H. Yang. 2007a. Growth performance and nitrogen metabolism in weaned pigs fed diets containing different sources of starch. Livest. Sci. 109:73-76 crossref(new window)

Li, L.-L., Y. -L. Yin, Y.-H. Liu, D.-X. Hou, Z.-P. Hou, C.-B Yang and X.-J. Yang. 2007b. Effects of metallothionein on antioxidative function and related enzyme activities in blood and liver, and pork meat quality. Asian-Aust. J. Anim. Sci. 20:761-767

Mallard, B. A., B. N. Wilkie, B. W. Kennedy, J. Gibson and M. Quinton. 1998. Immune responsiveness in swine: eight generations of selection for high and low immune response in Yorkshire pigs. Proc. 6th Wld. Congr. Genet. Appl. Livest. Prod. 27:257-264

McGlone, J. and W. Pond. 2003. Pig Production: biological principles and applications. Delmar Learning, Inc., Clifton Park, NY

McGlone, J. J., J. L. Salak, E. A. Lumpkin, R. I. Nicholson, M. Gibson and R. L. Norman. 1983. Shipping stress and social status effects on pig performance, plasma cortisol, natural killer cell activity, and leukocyte numbers. J. Anim. Sci. 71:888-890

Medzhitov, R. and C. Janeway. 2000. Innate immune recognition: mechanisms and pathways. Immunol. Rev. 173:89-97 crossref(new window)

Nabuurs, M. J. A. 1995. Microbiological, structural and functional changes of the small intestine of pigs at weaning. Pig News Inform. 16:93-97

Nishibe, S., H. Kinoshita, H. Takeda and G. Okano. 1990. Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chem. Pharmaceut. Bull. 38:1763-1765

Park, S. Y., S. Y. Chang, C. S. Yook and T. Nohara. 2000. New 3, 4-seco-lupane-type triterpene glycosides from Acanthopanax senticosus forma inermis. J. Nat. Prod. 63(12):1630-1633 crossref(new window)

Schmolz, M. W., F. Sacher and B. Aicher. 2001. The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytother. Res. 15:268- 270 crossref(new window)

Sean, X. L., Q. L. Xue, Y. Huang, L. Ferrucci, L. P. Fried and J. D. Walston. 2005. Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in communitydwelling older women. Exp. Gerontol. 40:982-987 crossref(new window)

Smith, R. 1999. Antibiotic bans, regulations may stop development of drugs. Feedstuffs. 71:1

Tang, Z. R., Y. L. Yin, Charles M. Nyachoti, R. L. Huang, T. J. Li, C. B. Yang, X. J. Yang, J. H. Gong, J. Peng, D. S. Qi, J. J. Xing, Z. H. Sun and M. Z. Fan. 2005. Effect of dietary supplementation of chitosan and galacto-mannanoligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets. Domist. Anim. Endocrin. 28:430-441 crossref(new window)

Tanigawa, K., R. A. Craig, L. M. Stoolman and A. E. Chang. 2000. Effects of tumor necrosis factor-alpha on the in vitro maturation of tumor-reactive effector T cells. J. Immunother. 23:528-535 crossref(new window)

Touchette, K. J., J. A. Carroll, G. L. Allee, R. L. Matteri, C. J. Dyer, L. A. Beausang and M. E. Zannelli. 2002. Effect of spray-dried plasma and lipopolysaccharide exposure on weaned pigs: I. Effects on the immune axis of weaned pigs. J. Anim. Sci. 80:494-501

Underhill, D. M. and A. Ozinsky. 2002. Phagocytosis of microbes. Annu. Rev. Immunol. 20:825-852 crossref(new window)

Van Heugten, E., M. T. Coffey and J. W. Spears. 1996. Effects of immune challenge, dietary energy density, and source of energy on performance and immunity in weanling pigs. J. Anim. Sci. 74:2431-2440

Wang, S., Y. T. Jia and Y. Y. Sun. 1996. Study on quantitive determination of flavonoids in the flavonoids of the composite Chinese material medica preparations. WCJ.PS. 11(2):95-96

Wina, E., S. Muetzel and K. Becker. 2005. The impact of saponins or saponin- containing plant materials on ruminant production: a review. J. Agric. Food Chem. 53(21):8093-8105 crossref(new window)

Wu, G., D. A. Knabe and S. W. Kim. 2004. Arginine nutrition in neonatal pigs. J. Nutr. 134:2783S-2390S

Wu, G., N. E. Flynn, D. A. Knabe and L. A. Jaeger. 2000. A cortisol surge mediates the enhanced polyamine synthesis in porcine enterocytes during weaning. Am. J. Physiol. 279:R554-R559

Wu, G., S. A. Meier and D. A. Knabe. 1996. Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs. J. Nutr. 126:2578-2584

Yang, C. H., G. Liu, C. X. Zhang and Y. L. Zheng. 2004. Progress of study on acanthopanax. Panax Res. 1:17-21

Yang, H., A. K. Li, Y. L. Yin, T. J. Li, Z. R. Wang, G. Wu, R. L. Huang, X. F. Kong, C. B. Yang, P. Kang, J. Deng, S. X. Wang, B. E. Tan, Q. Hu, F. F. Xing, X. Wu, Q. H. He, K. Yao, Z. J. Liu, Z. R. Tang, F. G. Yin, Z. Y. Deng, M. Y. Xie and M. Z. Fan. 2007. True phosphorus digestibility and the endogenous phosphorus outputs associated with brown rice for weanling pigs measured by the simple linear regression analysis technique weanling pigs. Anim. 1:213-220 crossref(new window)

Yi, J. M., M. S. Kim, S. W. Seo, K. N. Lee, C. S. Yook and H. M. Kim. 2001. Acanthopanax senticosus root inhibits mast celldependent anaphylaxis. Clin. Chim. Acta. 312:163-168 crossref(new window)

Yi, J. M., S. H. Hong, J. H. Kim, H. K. Kim, H. J. Song and H. M. Kim. 2002. Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis. J. Ethnopharmacol. 79(3):347-352 crossref(new window)

Yin, Y. L., H. Y. Zhong, R. L. Huang, C. M. Chen, T. J. Li and Y. F. Pai. 1993. Nutritive value of feedstuffs and diets for pigs. I. Chemical composition, apparent ileal and fecal digestibility. Anim. Feed Sci. Technol. 44:1-27 crossref(new window)

Yin, Y.-L., S. K. Baidoo and J. J. J. Boychul. 2001a Effect of replacing wheat and maize with micronization of dehulled barley on starter, grower and finisher pig perofrmance. Asian-Aust. J. Anim. Sci. 14:668-676

Yin, Y.-L, S. K. Baidoo, H. Schulze and P. H. Simmins. 2001b. Effect of supplementing diets containing hulless barley varieties having different levels of non-starch polysaccharides with ${\beta}-glucanase$ and xylanase on the physiological status of gastrointestinal tract and nutrient digestibility of weaned pigs. Livest. Prod. Sci. 71:97-107 crossref(new window)

Yin, Y.-L., S. K. Baidoo, Z. L. Jin, Y. G. Liu, H. Schulze and P. H. Simmins. 2001c.The effect of different carbohydrase and protease supplementation on apparent (ileal and overall) digestibility of nutrient of five hulless barley varieties in young pigs. Livest. Prod. Sci. 71:109-120 crossref(new window)

Yin, Y. L., R. L. Huang, H. Y. Zhong, T. J. Li, W. B. Souffrant and C. F. M. de Lange. 2002. Evaluation of mobile bag technique for determining apparent ileal digestibilities of crude protein and amino acids in growing pig. J. Anim. Sci. 80:409-420

Yin, Y.-L., Z.-Y. Deng, H.-L. Huang, T.-J. Li and H.Y. Zhong.2004. The effect of arabinoxylanase and protease supple-mentation on nutritional value of diets containing wheat bran or rice bran in growing pigs. J. Anim. Feed Sci. 13:445-461

Zhou, J., B. C. Wang and Y. Wang. 2005. Determination and evaluation of saccharides content in extract of herba spirodelae seu lemnae polysaccharides. J. Chongqing Univ. (Natural Science Edition) 28:111-114