JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Associations of Single Nucleotide Polymorphisms in BMPR-IB Gene with Egg Production in a Synthetic Broiler Line
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Associations of Single Nucleotide Polymorphisms in BMPR-IB Gene with Egg Production in a Synthetic Broiler Line
Zhang, N.B.; Tang, H.; Kang, L.; Ma, Y.H.; Cao, D.G.; Lu, Y.; Hou, M.; Jiang, Y.L.;
  PDF(new window)
 Abstract
Egg production traits are economically important both for egg-laying and broiler lines of chicken. In sheep, the Q249R mutation in BMPR-IB is associated with ovulation rate. The present study cloned a partial chicken BMPR-IB fragment which contained the corresponding ovine Q249R mutation, including partial exon 6 and exon 7 and full-length intron 6. Five nucleotide changes were identified by alignment of the fragment amplified from Jining Bairi and Zang chickens. Among these nucleotide substitutions, the C/T transition at the base position of 35 and the A/G transition at the base position of 287 were found to be highly polymorphic, and named as SNPs C35T and A287G, respectively. For the SNP C35T, 331 hens of a synthetic broiler line were genotyped by a PCR-SSCP approach and allele C was found to be dominant. For the SNP A287G, 604 birds from the synthetic broiler line, a commercial egg-laying line, as well as three Chinese indigenous chicken breeds were genotyped by a PCR-RFLP technique. The associations of these two SNPs with egg production traits in the broiler line were analyzed. The results indicated that both the C35T and the A287G SNPs were not associated with egg production at 33wks and from 33wks to 42 wks (p>0.1), whereas the SNP A287G was associated with egg production from 47 to 56 wks (p<0.05). The dominance genetic effects on this latter trait and on egg production from 33 to 42 wks were significant (p<0.05).
 Keywords
Chicken;BMPR-IB Gene;SNP;Egg Production;
 Language
English
 Cited by
1.
Estimation of Interaction Effects among Nucleotide Sequence Variants in Animal Genomes,;;

아세아태평양축산학회지, 2009. vol.22. 1, pp.124-130 crossref(new window)
 References
1.
Choi, C. H., B. W. Cho, G. J. Jeon and H. K. Lee. 2006. Identification of novel SNPs with effect on economic traits in uncoupling protein gene of Korean native chicken. Asian-Aust. J. Anim. Sci. 19(8):1065-1070.

2.
Cui, J. X., H. L. Du, Y. Liang, X. M. Deng, N. Li and X. Q. Zhang. 2005. Association of polymorphisms in the promoter region of chicken prolactin with egg production. Poult. Sci. 85(1):26-31.

3.
Ding, S. T., Y. H. Ko, B. R. Ou, P. H. Wang, C. L. Chen, M. C. Huang, Y. P. Lee, E. C. Lin, C. F. Chen, H. W. Lin and W. T. K. Cheng. 2008. The expression of genes related to egg production in the liver of Taiwan country chickens. Asian-Aust. J. Anim. Sci. 21(1):19-24.

4.
Dube, J. L., P. Wang, J. Elvin, K. M. Lyons, A. J. Celeste and M. M. Matzuk. 1998. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol. Endocrinol. 12:1809-1817. crossref(new window)

5.
Jiang, Y. L., X. Z. Fan, Z. X. Lu, H. Tang, J. Q. Xu and L. X. Du. 2002. Detection of $881^A{\rightarrow}881^G$ mutation in tyrosinase gene and associations with the Black ear Coat Color in rabbits. Asian-Aust. J. Anim. Sci. 15(10):1395-1397.

6.
Lim, Y., G. Cho, J. Minarcik and J. Golden. 2005. Altered BMP signaling disrupts chick diencephalic development. Mech. Dev. 122(4):603-620. crossref(new window)

7.
Mulsant, P., F. Lecerf, S. Fabre, L. Schibler, P. Monget, I. Lanneluc, C. Pisselet, J. Riquet, D. Monniaux, I. Callebaut, E. Cribiu, J. Thimonier, J. Teyssier, L. Bodin, Y. Cognie, N. Chitour and J. M. Elsen. 2001. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes. Proc. Natl. Acad. Sci. USA. 98:5104-5109. crossref(new window)

8.
Onagbesan, O. M., V. Bruggeman, P. Van As, K. Tona, J. Williams, and E. Decuypere. 2003. BMPs and BMPRs in chicken ovary and effects of BMP-4 and -7on granulosa cell proliferation and progesterone production in vitro. Am. J. Physiol. Endocrinol. Metab. 285:E973-E983.

9.
Shimasaki, S., R. J. Zachow, D. Li, H. Kim, S. Iemura, N. Ueno, K. Sampath, R. J. Chang and G.. F. Erickson. 1999. A functional bone morphogenetic protein system in the ovary. Proc. Natl. Acad. Sci. USA. 96:7282-7287. crossref(new window)

10.
Souza, C. J., B. K. Campbell, A. S. McNeilly and D. T. Baird. 2001. The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1B (BMPR1B) gene. J. Endocrinol. 169:R1-R6. crossref(new window)

11.
Sumitomo, S., T. Saito and T. Nohno. 1993. A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta. DNA Seq. 3(5):297-302.

12.
Wilson, T., X. Y. Wu, J. L. Juengel, I. K. Ross, J. M. Lumsden, E. A. Lord, K. G. Dodds, G. A. Walling, J. C. McEwan, A. R. O'Connell, K. P. McNatty and G. W. Montgomery. 2001. Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Biol. Reprod. 64:1225-1235. crossref(new window)