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Growth Hormone Signaling in the Regulation of Acid Labile Subunit
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 Title & Authors
Growth Hormone Signaling in the Regulation of Acid Labile Subunit
Kim, Jin Wook; Boisclair, Yves R.;
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The past decades have seen enormous advances in our understanding of how GH acts. GH is a pituitary-derived polypeptide hormone that has diverse physiological effects including the regulation of bone growth, carbohydrate and lipid metabolism. The effects of GH are mediated directly and indirectly through IGF-I. In addition, GH stimulates the hepatic production of ALS. In postnatal life, IGF-I and -II circulate as 150 kDa ternary complexes consisting of one molecule each of IGFBP-3 or IGFBP-5, IGF-I or IGF-II and ALS. It is now known that ALS increases significantly the half-lives of the IGFs, IGFBP-3 and -5, and therefore is responsible for maintaining a circulating reservoir for each of these proteins.
Growth Hormone;Signaling;Acid Labile Subunit;
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Adams, T. E., J. A. Hansen, R. Starr, N. A. Nicola, D. J. Hilton and N. Billestrup. 1998. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273:1285-1287. crossref(new window)

Agarwal, S. K., L. A. Cogburn and J. Burnside. 1994. Dysfunctional growth hormone receptor in a strain of sexlinked dwarf chicken: evidence for a mutation in the intracellular domain. J. Endocrinol. 142:427-434. crossref(new window)

Akers, R. M. 1985. Lactogenic hormones: binding sites, mammary growth, secretory cell differentiation, and milk biosynthesis in ruminants. J. Dairy Sci. 68:501-519. crossref(new window)

Argetsinger, L. S., G. W. Hsu, M. G. Myers Jr., N. Billestrup, M. F. White and C. Carter-Su. 1995. Growth hormone, interferon gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270:14685-14692. crossref(new window)

Argetsinger, L. S., G. Norstedt, N. Billestrup, M. F. White and C. Carter-Su. 1996. Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling. J. Biol. Chem. 271:29415-19421. crossref(new window)

Baker, J., J. P. Liu, E. J. Robertson and A. Efstratiadis. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73-82.

Barbano, D. M., J. M. Lynch, D. E. Bauman, G. F. Hartnell, R. L. Hintz and M. A. Nemeth. 1992. Effect of a prolonged-release formation of N-methionyl bovine somatotropin (sometribove) on milk composition. J. Dairy Sci. 75:1775-1793. crossref(new window)

Barreca, A., P. Ponzani, M. Arvigo, G. Giordano and F. Minuto. 1995. Effect of the acid-labile subunit on the binding of insulin-like growth factor (IGF)-binding protein-3 to [125I]IGF-I. J. Clin. Endocrinol. Metab. 80:1318-1324. crossref(new window)

Bauman, D. E. 1999. Bovine somatotropin and lactation: from basic science to commercial application. Domest. Anim. Endocrinol. 17:101-116. crossref(new window)

Bauman, D. E. and R. G. Vernon. 1993. Effects of exogenous bovine somatotropin on lactation. Annu. Rev. Nutr. 13:437-461. crossref(new window)

Baumbach, W. R., D. L. Horner and J. S. Logan. 1989. The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor. Genes Dev. 3:1199-1205. crossref(new window)

Baxter, R. C. 1988. Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex. J. Clin. Endocrinol. Metab. 67:265-272. crossref(new window)

Baxter, R. C. 1990. Circulating levels and molecular distribution of the acid-labile (alpha) subunit of the high molecular weight insulin-like growth factor- binding protein complex. J. Clin. Endocrinol. Metab. 70:1347-1353. crossref(new window)

Baxter, R. C. and W. H. Daughaday. 1991. Impaired formation of the ternary insulin-like growth factor-binding protein complex in patients with hypoglycemia due to nonislet cell tumors. J. Clin. Endocrinol. Metab. 73:696-702. crossref(new window)

Baxter, R. C. and J. L. Martin. 1989. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinitylabeling. Proc. Natl. Acad. Sci. USA 86:6898-6902. crossref(new window)

Baxter, R. C., J. L. Martin and V. A. Beniac. 1989. High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. J. Biol. Chem. 264:11843-11848.

Bereket, A., T. A. Wilson, S. L. Blethen, Y. Sakurai, D. N. Herndon, R. R. Wolfe and C. H. Lang. 1996. Regulation of the acid-labile subunit of the insulin-like growth factor ternary complex in patients with insulin-dependent diabetes mellitus and severe burns. Clin. Endocrinol. (Oxf) 44:525-532. crossref(new window)

Binoux, M. and P. Hossenlopp. 1988. Insulin-like growth factor (IGF) and IGF-binding proteins: comparison of human serum and lymph. J. Clin. Endocrinol. Metab. 67:509-514. crossref(new window)

Boisclair, Y. R., D. E. Bauman, A. W. Bell, F. R. Dunshea and M. Harkins. 1994. Nutrient utilization and protein turnover in the hindlimb of cattle treated with bovine somatotropin. J. Nutr. 124:664-673.

Boisclair, Y. R., D. Seto, S. Hsieh, K. R. Hurst and G. T. Ooi. 1996. Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc. Natl. Acad. Sci. USA 93:10028-10033. crossref(new window)

Boisclair, Y. R., J. Wang, J. Shi, K. R. Hurst and G. T. Ooi. 2000. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormonedependent transcription of the acid-labile subunit gene in liver cells. J. Biol. Chem. 275:3841-3847. crossref(new window)

Bousquet, C., C. Susini and S. Melmed. 1999. Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor. J. Clin. Invest. 104:1277-1285. crossref(new window)

Bruning, J. C., J. Winnay, B. Cheatham and C. R. Kahn. 1997. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol. Cell. Biol. 17:1513-1521.

Burrin, D. G., T. A. Davis, M. L. Fiorotto and P. J. Reeds. 1997. Role of milk-borne vs. endogenous insulin-like growth factor I in neonatal growth. J. Anim. Sci. 75:2739-2743.

Butler, J. H. and P. D. Gluckman. 1986. Circulating insulin-like growth factor-binding proteins in fetal, neonatal and adult sheep. J. Endocrinol. 109:333-338. crossref(new window)

Campbell, G. S., D. J. Meyer, R. Raz, D. E. Levy, J. Schwartz and C. Carter-Su. 1995. Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone. J. Biol. Chem. 270:3974-3979. crossref(new window)

Campbell, R. G., R. J. Johnson, M. R. Taverner and R. H. King. 1991. Interrelationships between exogenous porcine somatotropin (PST) administration and dietary protein and energy intake on protein deposition capacity and energy metabolism of pigs. J. Anim. Sci. 69:1522-1531.

Carter-Su, C., L. Rui and J. Herrington. 2000a. Role of the tyrosine kinase JAK2 in signal transduction by growth hormone. Pediatr. Nephrol. 14:550-557. crossref(new window)

Carter-Su, C., L. Rui and M. R. Stofega. 2000b. SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. Recent. Prog. Horm. Res. 55:293-311.

Chalupa, W. and D. T. Galligan. 1989. Nutritional implications of somatotropin for lactating cows. J. Dairy Sci. 72:2510-2524. crossref(new window)

Chin, E., J. Zhou, J. Dai, R. C. Baxter and C. A. Bondy. 1994. Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex. Endocrinol. 134:2498-2504. crossref(new window)

Chung, C. S., T. D. Etherton and J. P. Wiggins. 1985. Stimulation of swine growth by porcine growth hormone. J. Anim. Sci. 60:118-130.

Cobb, M. H. 1999. MAP kinase pathways. Prog. Biophys. Mol. Biol. 71:479-500. crossref(new window)

Cohick, W. S. 1998. Role of the insulin-like growth factors and their binding proteins in lactation. J. Dairy Sci. 81:1769-1777. crossref(new window)

Cramer, S. D. and F. Talamantes. 1993. The growth hormone receptor and growth hormone-binding protein:structure, functions, and regulation. New York.

Dai, J. and R. C. Baxter. 1992. Molecular cloning of the acidlabile subunit of the rat insulin-like growth factor binding protein complex. Biochem. Biophys. Res. Commun. 188:304-309. crossref(new window)

Dai, J. and R. C. Baxter. 1994. Regulation in vivo of the acid-labile subunit of the rat serum insulin-like growth factor-binding protein complex. Endocrinology 135:2335-2341. crossref(new window)

Dai, J., C. D. Scott and R. C. Baxter. 1994. Regulation of the acidlabile subunit of the insulin-like growth factor complex in cultured rat hepatocytes. Endocrinol. 135:1066-1072. crossref(new window)

Daughaday, W. H., K. Hall, M. S. Raben, W. D. Salmon Jr., J. L. van den Brande and J. J. van Wyk. 1972. Somatomedin: proposed designation for sulphation factor. Nature 235:107. crossref(new window)

Daughaday, W. H. and P. Rotwein. 1989. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr. Rev. 10:68-91. crossref(new window)

Davey, H. W., M. J. McLachlan, R. J. Wilkins, D. J. Hilton and T. E. Adams. 1999. STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver. Mol. Cell. Endocrinol. 158:111-116. crossref(new window)

Davey, H. W., T. Xie, M. J. McLachlan, R. J. Wilkins, D. J. Waxman and D. R. Grattan. 2001. STAT5b is required for GHinduced liver IGF-I gene expression. Endocrinology 142:3836-3841. crossref(new window)

Davis, T. A., M. L. Fiorotto, D. G. Burrin, W. G. Pond and H. V. Nguyen. 1997. Intrauterine growth restriction does not alter response of protein synthesis to feeding in newborn pigs. Am. J. Physiol. 272:E877-884.

Delhanty, P. and R. C. Baxter. 1996. The cloning and expression of the baboon acid-labile subunit of the insulin-like growth factor binding protein complex. Biochem. Biophys. Res. Commun. 227:897-902. crossref(new window)

Delhanty, P. J. and R. C. Baxter. 1998. The regulation of acidlabile subunit gene expression and secretion by cyclic adenosine 3',5'-monophosphate. Endocrinol. 139:260-265. crossref(new window)

Domene, H. M., M. S. Bengolia, A. S. Martinez, M. G. Ropelato, P. Pennisi, P. H. J. Scaglia and H. G. Jasper. 2004. Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene. The New England Journal of Medicine 350:570-577. crossref(new window)

Donaghy, A. J., P. J. Delhanty, K. K. Ho, R. Williams and R. C. Baxter. 2002. Regulation of the growth hormone receptor/binding protein, insulin-like growth factor ternary complex system in human cirrhosis. J. Hepatol. 36:751-758. crossref(new window)

Doris, R., R. G. Vernon, M. D. Houslay and E. Kilgour. 1994. Growth hormone decreases the response to anti-lipolytic agonists and decreases the levels of Gi2 in rat adipocytes. Biochem. J. 297 ( Pt 1):41-45.

Doris, R. A., G. E. Thompson, E. Finley, E. Kilgour, M. D. Houslay and R. G. Vernon. 1996. Chronic effects of somatotropin treatment on response of subcutaneous adipose tissue lipolysis to acutely acting factors in vivo and in vitro. J. Anim. Sci. 74:562-568.

Dunshea, F. R., D. M. Harris, D. E. Bauman, R. D. Boyd and A. W. Bell. 1992. Effect of porcine somatotropin on in vivo glucose kinetics and lipogenesis in growing pigs. J. Anim. Sci. 70:141-151.

Edens, A. and F. Talamantes. 1998. Alternative processing of growth hormone receptor transcripts. Endocr. Rev. 19:559-582. crossref(new window)

Eisemann, J. H., A. C. Hammond, D. E. Bauman, P. J. Reynolds, S. N. McCutcheon, H. F. Tyrrell and G. L. Haaland. 1986. Effect of bovine growth hormone administration on metabolism of growing Hereford heifers: protein and lipid metabolism and plasma concentrations of metabolites and hormones. J. Nutr. 116:2504-2515.

Eisemann, J. H., A. C. Hammond, T. S. Rumsey and D. E. Bauman. 1989. Nitrogen and protein metabolism and metabolites in plasma and urine of beef steers treated with somatotropin. J. Anim. Sci. 67:105-115.

Etherton, T. D. and D. E. Bauman. 1998. Biology of somatotropin in growth and lactation of domestic animals. Physiol. Rev. 78:745-761.

Etherton, T. D., I. Louveau, M. T. Sorensen and S. Chaudhuri. 1993. Mechanisms by which somatotropin decreases adipose tissue growth. Am. J. Clin. Nutr. 58:287S-295S.

Etherton, T. D., J. P. Wiggins, C. M. Evock, C. S. Chung, J. F. Rebhun, P. E. Walton and N. C. Steele. 1987. Stimulation of pig growth performance by porcine growth hormone: determination of the dose-response relationship. J. Anim. Sci. 64:433-443.

Evock, C. M., T. D. Etherton, C. S. Chung and R. E. Ivy. 1988. Pituitary porcine growth hormone (pGH) and a recombinant pGH analog stimulate pig growth performance in a similar manner. J. Anim. Sci. 66:1928-1941.

Finidori, J. 2000. Regulators of growth hormone signaling. Vitam. Horm. 59:71-97. crossref(new window)

Firth, S. M., U. Ganeshprasad and R. C. Baxter. 1998. Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3. J. Biol. Chem. 273:2631-2638. crossref(new window)

Fowden, A. L. 1995. Endocrine regulation of fetal growth. Reprod. Fertil. Dev. 7:351-363. crossref(new window)

Frystyk, J., P. J. Delhanty, C. Skjaerbaek and R. C. Baxter. 1999. Changes in the circulating IGF system during short-term fasting and refeeding in rats. Am. J. Physiol. 277:E245-252.

Frystyk, J., H. Gronbaek, C. Skjaerbaek, A. Flyvbjerg, H. Orskov and R. C. Baxter. 1998. Developmental changes in serum levels of free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit in rats. Endocrinology 139:4286-4292. crossref(new window)

Fukuda, I., M. Hotta, N. Hizuka, K. Takano, Y. Ishikawa, K. Asakawa-Yasumoto, E. Tagami and H. Demura. 1999. Decreased serum levels of acid-labile subunit in patients with anorexia nervosa. J. Clin. Endocrinol. Metab. 84:2034-2036. crossref(new window)

Gargosky, S. E., P. Tapanainen and R. G. Rosenfeld. 1994. Administration of growth hormone (GH), but not insulin-like growth factor-I (IGF-I), by continuous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats. Endocrinol. 134:2267-2276. crossref(new window)

Gaur, S., H. Yamaguchi and H. M. Goodman 1996. Growth hormone increases calcium uptake in rat fat cells by a mechanism dependent on protein kinase C. Am. J. Physiol. 270:C1485-1492.

Gertler, A., A. Ashkenazi and Z. Madar. 1984. Binding sites of human growth hormone and ovine and bovine prolactins in the mammary gland and the liver of lactating dairy cow. Mol. Cell. Endocrinol. 34:51-57. crossref(new window)

Glimm, D. R., V. E. Baracos and J. J. Kennelly. 1990. Molecular evidence for the presence of growth hormone receptors in the bovine mammary gland. J. Endocrinol. 126:R5-8. crossref(new window)

Glimm, D. R., V. E. Baracos and J. J. Kennelly. 1992. Northern and in situ hybridization analyses of the effects of somatotropin on bovine mammary gene expression. J. Dairy Sci. 75:2687-2705. crossref(new window)

Goodman, G. T., R. M. Akers, K. H. Friderici and H. A. Tucker. 1983. Hormonal regulation of alpha-lactalbumin secretion from bovine mammary tissue cultured in vitro. Endocrinol. 112:1324-1330. crossref(new window)

Gopinath, R. and T. D. Etherton. 1989. Effects of porcine growth hormone on glucose metabolism of pigs: II. Glucose tolerance, peripheral tissue insulin sensitivity and glucose kinetics. J. Anim. Sci. 67:689-697.

Gu, F., N. Dube, J. W. Kim, A. Cheng, J. Ibarra-Sanchez Mde, M. L.Tremblay and Y. R. Boisclair. 2003. Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol. Cell. Biol. 23:3753-3762. crossref(new window)

Gurland, G., G. Ashcom, B. H. Cochran and J. Schwartz. 1990. Rapid events in growth hormone action. Induction of c-fos and c-jun transcription in 3T3-F442A preadipocytes. Endocrinol. 127:3187-3195. crossref(new window)

Hackett, R. H., Y. D. Wang, S. Sweitzer, G. Feldman, W. I. Wood. and A. C. Larner. 1997. Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins. J. Biol. Chem. 272:11128-11132. crossref(new window)

Haluzik, M., S. Yakar, O. Gavrilova, J. Setser, Y. Boisclair and D. LeRoith. 2003. Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance. Diabetes 52:2483-2489. crossref(new window)

Hammond, A. C., T. H. Elsasser and T. A. Olson. 1991. Endocrine characteristics of a miniature condition in Brahman cattle: circulating concentrations of some growth-related hormones. Proc. Soc. Exp. Biol. Med. 197:450-457.

Harris, D. M., F. R. Dunshea, D. E. Bauman, R. D. Boyd, S. Y. Wang, P. A. Johnson and S. D. Clarke. 1993. Effect of in vivo somatotropin treatment of growing pigs on adipose tissue lipogenesis. J. Anim. Sci. 71:3293-300.

Hashimoto, R., M. Ono, H. Fujiwara, N. Higashihashi, M. Yoshida, T. Enjoh-Kimura and K. Sakano. 1997. Binding sites and binding properties of binary and ternary complexes of insulinlike growth factor-II (IGF-II), IGF-binding protein-3, and acidlabile subunit. J. Biol. Chem. 272:27936-27942. crossref(new window)

Hauser, S. D., M. F. McGrath, R. J. Collier and G. G. Krivi. 1990. Cloning and in vivo expression of bovine growth hormone receptor mRNA. Mol. Cell. Endocrinol. 72:187-200. crossref(new window)

Heap, D., R. J. Collier, C. K. Boyd and M. C. Lucy. 1996. Expression of alternate growth hormone receptor messenger RNA in ovary and uterus of cattle. Domest. Anim. Endocrinol. 13:421-430. crossref(new window)

Heap, D., M. C. Lucy, R. J. Collier, C. K. Boyd and W. C. Warren. 1995. Rapid communication: nucleotide sequence of the promoter and first exon of the somatotropin receptor gene in cattle. J. Anim. Sci. 73:1529.

Herrington, J. and C. Carter-Su. 2001. Signaling pathways activated by the growth hormone receptor. Trends Endocrinol. Metab. 12:252-257. crossref(new window)

Herrington, J., L. S. Smit, J. Schwartz and C. Carter-Su. 2000. The role of STAT proteins in growth hormone signaling. Oncogene 19:2585-2597. crossref(new window)

Hodge, C., J. Liao, M. Stofega, K. Guan, C. Carter-Su and J. Schwartz, J. 1998. Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signalregulated kinases 1 and 2. J. Biol. Chem. 273:31327-1336. crossref(new window)

Hodgkinson, S. C., L. Moore, J. R. Napier, S. R. Davis, J. J. Bass and P. D. Gluckman. 1989. Characterization of insulin-like growth factor binding proteins in ovine tissue fluids. J. Endocrinol. 120:429-438. crossref(new window)

Holland, M. D., K. L. Hossner, S. E. Williams, C. R. Wallace, G. D. Niswender and K. G. Odde. 1997. Serum concentrations of insulin-like growth factors and placental lactogen during gestation in cattle. I. Fetal profiles. Domest. Anim. Endocrinol. 14:231-239. crossref(new window)

Horber, F. F. and M. W. Haymond. 1990. Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J. Clin. Invest. 86:265-272. crossref(new window)

Houseknecht, K. L., D. A. Dwyer, D. P. Lanna and D. E. Bauman. 1995. Effect of somatotropin on adipose tissue metabolism: ontogeny of the enhanced response to adrenergic challenge in the lactating cow. Domest. Anim. Endocrinol. 12:105-113. crossref(new window)

Hughes, S. C., H. D. Mason, S. Franks and J. M. Holly. 1997. The insulin-like growth factors (IGFs) in follicular fluid are predominantly bound in the ternary complex. J. Endocrinol. 155:R1-4. crossref(new window)

Imada, K. and W. J. Leonard. 2000. The Jak-STAT pathway. Mol. Immunol. 37:1-11. crossref(new window)

Ingvartsen, K. L. and J. B. Andersen. 2000. Integration of metabolism and intake regulation: a review focusing on periparturient animals. J. Dairy Sci. 83:1573-1597. crossref(new window)

Janosi, J. B., S. M. Firth, J. J. Bond, R. C. Baxter and P. J. Delhanty. 1999a. N-Linked glycosylation and sialylation of the acid-labile subunit. Role in complex formation with insulinlike growth factor (IGF)-binding protein-3 and the IGFs. J. Biol. Chem. 274:5292-5298. crossref(new window)

Janosi, J. B., P. A. Ramsland, M. R. Mott, S. M. Firth, R. C. Baxter and P. J. Delhanty. 1999b. The acid-labile subunit of the serum insulin-like growth factor-binding protein complexes. Structural determination by molecular modeling and electron microscopy. J. Biol. Chem. 274:23328-23332. crossref(new window)

Jiang, H. and M. C. Lucy. 2001a. Involvement of hepatocyte nuclear factor-4 in the expression of the growth hormone receptor 1A messenger ribonucleic acid in bovine liver. Mol. Endocrinol. 15:1023-1034. crossref(new window)

Jiang, H. and M. C. Lucy. 2001b. Variants of the 5'-untranslated region of the bovine growth hormone receptor mRNA: isolation, expression and effects on translational efficiency. Gene 265:45-53. crossref(new window)

Jiang, H., C. S. Okamura, C. K. Boyd and M. C. Lucy. 2000. Identification of Sp1 as the transcription factor for the alternative promoter P2 of the bovine growth hormone receptor gene. J. Mol. Endocrinol. 24:203-214. crossref(new window)

Jiang, H., C. S. Okamura and M. C. Lucy. 1999. Isolation and characterization of a novel promoter for the bovine growth hormone receptor gene. J. Biol. Chem. 274:7893-7900. crossref(new window)

Jiang, H., Y. Wang, M. Wu, Z. Gu, S. J. Frank and R. Torres-Diaz. 2007. Growth hormone stimulates hepatic expression of bovine growth hormone receptor mRNA through STATactivation of a major growth hormone receptor gene promoter. Endocrinol. 148(7):3307-3315. crossref(new window)

Katz, L. E., F. Liu, B. Baker, M. S. Agus, S. E. Nunn, R. L. Hintz and P. Cohen. 1996. The effect of growth hormone treatment on the insulin-like growth factor axis in a child with nonislet cell tumor hypoglycemia. J. Clin. Endocrinol. Metab. 81:1141-1146. crossref(new window)

Keys, J. E. and J. Djiane. 1988. Prolactin and growth hormone binding in mammary and liver tissue of lactating cows. J. Recept. Res. 8:731-750.