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Quantitative Trait Loci Affecting Rous Sarcoma Virus Induced Tumor Regression Trait in F2 Intercross Chickens
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 Title & Authors
Quantitative Trait Loci Affecting Rous Sarcoma Virus Induced Tumor Regression Trait in F2 Intercross Chickens
Uemoto, Y.; Saburi, J.; Sato, S.; Odawara, S.; Ohtake, T.; Yamamoto, R.; Miyata, T.; Suzuki, K.; Yamashita, H.; Irina, C.; Plastow, G.; Mitsuhashi, T.; Kobayashi, E.;
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 Abstract
We performed a genome-wide linkage and quantitative trait locus (QTL) analysis to confirm the existence of QTL affecting Rous Sarcoma Virus (RSV) induced tumor regression, and to estimate their effects on phenotypic variance in an F2 resource population. The F2 population comprised 158 chickens obtained by crossing tumor regressive White Leghorn (WL) and tumor progressive Rhode Island Red (RIR) lines was measured for tumor formation after RSV inoculation. Forty-three tumor progressive and 28 tumor regressive chickens were then used for genome-wide linkage and QTL analysis using a total of 186 microsatellite markers. Microsatellite markers were mapped on 20 autosomal chromosomes. A significant QTL was detected with marker LEI0258 located within the MHC B region on chromosome 16. This QTL had the highest F ratio (9.8) and accounted for 20.1% of the phenotypic variation. Suggestive QTL were also detected on chromosomes 4, 7 and 10. The QTL on chromosome 4 were detected at the 1% chromosome-wide level explaining 17.5% of the phenotypic variation, and the QTLs on chromosome 7 and 10 were detected at the 5% chromosome-wide level and explained 11.1% and 10.5% of the phenotypic variation, respectively. These results indicate that the QTLs in the non-MHC regions play a significant role in RSV-induced tumor regression. The present study constitutes one of the first preliminary reports in domestic chickens for QTLs affecting RSV-induced tumor regression outside the MHC region.
 Keywords
Chicken;Quantitative Trait Locus;Tumor Regression;Subgroup A Rous Sarcoma Virus;Non-MHC;
 Language
English
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 References
1.
Abasht, B., J. C. Dekkers and S. J. Lamont. 2006, Review of quantitative trait loci identified in the chicken, Poult. Sci. 85: 2079-2096

2.
Brown, D. W., W. M. Collins, R. M. Zsigray and W. E. Briles. 1984, A non-MHC genetic influence on response to Rous sarcoma virus-induced tumors in chickens, Avian Dis. 28:884-899 crossref(new window)

3.
Bacon, L. D., R. L. Witter, L. B. Crittenden, A. Fadly and J. Motta.1981, B-haplotype influence on Marek's disease, Rous sarcoma, and lymphoid leukosis virus-induced tumors in chickens. Poult. Sci. 60:1132-1139

4.
Calnek, B. W., D. A. Higgins and J. Fabricant. 1975, Rous sarcoma regression in chickens resistant or susceptible to Marek's disease, Avian Dis. 19:473-482 crossref(new window)

5.
Carte, I. F., J. H. Smith, C. R. Weston and T. F. Savage. 1972, immunogenetics and regression of RSV (RAV-1) wing web tumors in chickens, Poult. Sci. 51:1792 (Abstr)

6.
Cole, R. K. 1968, Studies on genetic resistance to Marek's disease, Avian Dis. 12:9-28 crossref(new window)

7.
Collins, W. M., W. E. Briles, R. M. Zsigray, W. R. Dunlop, A. C. Corbett, K. K. Clark, J. L. Marks and T. P. MacGrail. 1977, The B locus (MHC) in the chicken: Association with the fate of RSV-induced tumors, Immunogenetics 5:333-343 crossref(new window)

8.
Bates, P., L. Rong, H. E. Varmus, J. A. T. Young and L. B. Crittenden. 1998, Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus, J. Virol. 72:2505-2508

9.
Elleder, D., D. C. Melder, K. Trejbalova, J. Svoboda and M. J. Federspiel. 2004, Two different molecular defects in the tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses, J. Virol. 78:13489-13500 crossref(new window)

10.
Fulton, J., H. R. Juul-Madsen, C. M. Ashwell, A. A. McCarron, J. A. Arthur, N. P. O'Sullivan and R. L. Taylor. 2006, Molecular genotype identification of the gallus gallus major histocompatibility complex, Immunogenetics 58:407-421 crossref(new window)

11.
Gelman, I. H. and H. Hanafusa. 1993, src-Specific immune regression of Rous sarcoma virus-induced tumors, Cancer Res.15:915-920

12.
Green, P., K. Falls and S. Crooks. 1990, Documentation for CRIMAP. Version 2.4. Washington University School of Medicine, ST. Louis, MO

13.
Haley, C. S., S. A. Knott and J. M. Elsen. 1994, Mapping quantitative trait loci in crosses between outbred lines using least squares, Genetics 136:1195-1207

14.
Hirooka, H., D. J. de Koning, J. A. van Arendonk, B. Harlizius, P. N. de Groot and H. Bovenhuis. 2002, Genome scan reveals new coat color loci in exotic pig cross. J. Hered. 93:1-8 crossref(new window)

15.
Kaufman, J. and K. Venugopal. 1998, The importance of MHC for Rous sarcoma virus and Marek's disease virus - some Payneful considerations, Avian Pathol. 27:82-87 crossref(new window)

16.
Knap, P. W. and S. C. Bishop. 2000, Relationships between genetic change and infectious disease in domestic livestock. In: The challenge of genetic change in animal production (Ed. W. G. Hill, S. C. Bishop, B. McGuirk, J. C. McKay, G. Simm and A. J. Webb) British Society of Animal Science, Edinburgh, Occasional publication no. 27, pp. 65-80

17.
Knott, S. A., L. Marklund, C. S. Haley, K. Andersson, W. Davies, H. Ellegren, M. Fredholm, I. Hansson, B. Hoyheim, K. Lundstrom, M. Moller and L. Andersson. 1998, Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and Large White pigs, Genetics 149:1069-1080 crossref(new window)

18.
Lamont, S. J. 1998, Impact of genetics on disease resistance, Poult. Sci. 77:1111-1118

19.
McKay, J. C., N. F. Barton, A. N. M. Koerhuis and J. McAdam. 2000, The challenge of genetic change in the broiler chicken. In: The challenge of genetic change in animal production (Ed. W. G. Hill, S. C. Bishop, B. McGuirk, J. C. McKay, G. Simm and A. J. Webb) British Society of Animal Science, Edinburgh, Occasional publication no. 27, pp. 1-7

20.
Okada, I., Y. Yamada, M. Akiyama, I. Nishimura and N. Kano. 1977, Changes in polymorphic gene frequencies in strains of chickens selected for resistance to marek's disease, Br. Poult. Sci. 18:237-246 crossref(new window)

21.
Praharaj, N., C. Beaumont, G. Dambrine, D. Soubieux, L. Merat, D. Bouret, G. Luneau, J. M. Alletru, M. H. Pinard-Van der Laan, P. Thoraval and S. Mignon-Grasteau. 2004, Genetic analysis of the growth curve of rous sarcoma virus-induced tumors in chickens, Poult. Sci. 83:1479-1488

22.
Rous, P. 1911, A sarcoma of the fowl transmissible by an agent seperable from the tumor cell, J. Exp. Med. 13:397-411 crossref(new window)

23.
Seaton, G., C. S. Haley, S. A. Knott, M. Kearsey and P. M. Visscher. 2002, QTL EXPRESS: mapping quantitative trait loci in simple and complex pedigrees, Bioinformatics 18:339-340 crossref(new window)

24.
Svoboda, J., J. Plachy, J. Hejnar, I. Karakoz, R. V. Cuntaka and J. Geryk. 1992, Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens, Immunogenetics 35:309-315

25.
Taylor, R. L. 2004, Major histocompatibility (B) complex control of responses against Rous sarcomas, Poult. Sci. 83:638-649

26.
Vallejo, R. L., L. D. Bacon, H. C. Liu, R. L. Witter, M. A. M. Groenen, J. Hillel and H. H. Cheng. 1998, Genetic mapping of Marek's disease virus induced tumors in F2 intercross chickens, Genetics 148:349-360

27.
Visscher, P. M., C. S. Haley and S. A. Knott. 1996, Mapping QTL for binary traits in backcross and F2 populations, Genet. Res.68:55-63 crossref(new window)

28.
Yonash, N., L. D. Bacon, R. L. Witter and H. H. Cheng. 1999, High resolution mapping and identification of new quantitative trait loci (QTL) affecting susceptibility to Marek's disease, Anim. Genet. 30:126-135 crossref(new window)