Advanced SearchSearch Tips
Effects of Oral Administration of Difructose Anhydride III on Selected Health and Blood Parameters of Group-housed Japanese Black Calves during the Preweaning Period
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effects of Oral Administration of Difructose Anhydride III on Selected Health and Blood Parameters of Group-housed Japanese Black Calves during the Preweaning Period
Matsumoto, Daisaku; Takagi, Mitsuhiro; Hasunuma, Hiroshi; Fushimi, Yasuo; Ohtani, Masayuki; Sato, Tadashi; Okamoto, Koji; Shahada, Francis; Tanaka, Tetsuya; Deguchi, Eisaburo;
  PDF(new window)
Two field studies were conducted to determine the efficacy of difructose anhydride III (DFA III) as a supplement in colostrum replacer (CR) for improving the general health status (judged on the basis of incidence of enteritis, bronchitis, and pneumonia) of group-housed suckling Japanese Black calves. In a preliminary study, CR supplemented with DFA III (6 g) was orally administered within 24 h of calving to eight individually reared calves fed colostrum (DFA III group) (Exp. 1). Subsequently, CR supplemented with DFA III (6 g) was orally administered twice within 2 and 12 h of calving to four calves (DFA III group) that were not fed colostrum (Exp. 2). In both experiments, the health status of the calves was assessed during the preweaning period. In Exp. 2, hematological and blood-chemistry parameters were analyzed 24 h after the second administration of CR and at 1 wk and 1 month after calving. The results were compared between the DFA III and control groups (without DFA III supplementation; Exp. 1: n = 10, Exp. 2: n = 4). In Exp. 1, the number of calves requiring medications for the treatment of enteritis, bronchitis, and pneumonia during the preweaning period was significantly (p<0.05) lower in the DFA III group than in the control group. In Exp. 2, supplementation of DFA III did not influence the gain in body weight of calves during the pre-weaning period. Calves in the DFA III group tended to require medications for a shorter duration than those in the control group (DFA III: 10.3 d/calf, control: 21.3 d/calf; p = 0.07). Significant differences (p<0.05) in the level of mean corpuscular hemoglobin, total protein, total cholesterol, and immunoglobulin (Ig)G were observed between the DFA III and control groups. These differences probably reflect the health and nutritional status of the calves. Additionally, the serum iron and lactoferrin concentrations at 24 h and 1 wk after calving, respectively, differed significantly between the 2 groups. These concentrations might reflect the incidence of infections after calving. The present study revealed that the administration of DFA III as a CR supplement may prevent diseases in group-housed calves during the pre-weaning period.
Calf;DFA III;Prebiotics;Group Housing;Lactoferrin;
 Cited by
Andrieu, S. 2008. Is there a role for organic trace element supplement in transition cow health? Vet. J. 176:77-83 crossref(new window)

Bennett, R. M. and T. Kokocinski. 1978. Lactoferrin content of peripheral blood cells. Br. J. Haematol. 39:509-521 crossref(new window)

Besser, T. E. and C. C. Gay. 1994. The importance of colostrum to the health of the neonatal calf. Vet. Clin. North Am. Food Anim. Pract. 10:107-117

Cray, W. C., T. A. Casey, B. T. Bosworth and M. A. Rasmussen. 1998. Effect of dietary stress on fecal shedding of Escherichia coli O157: H7 in calves. Appl. Environ. Microbiol. 64:1975-1979

Donovan, D. C., S. T. Franklin, C. C. L. Chase and A. R. Hippen. 2002. Growth and health of Holstein calves fed milk replacers supplemented with antibiotics or enteroguard. J. Dairy Sci. 85:947-950 crossref(new window)

Fleige, S., W. Preibinger, H. H. D. Meyer and M. W. Pfaffl. 2007. Effect of lactulose on growth performance and intestinal morphology of pre-ruminant calves using a milk replacer containing Enterococcus faecium. Animal 1:367-373 crossref(new window)

Fleige, S., W. Preibinger, H. H. D. Meyer and M. W. Pfaffl. 2008. The immuno-modulatory effect of lactulose on Enterococcus faecium fed pre-ruminant calves. J. Anim. Sci. (In press)

Franklin, S. T., M. C. Newman, K. E. Newman and K. I. Meek. 2005. Immune parameters of dry cows fed mannan oligosaccharide and subsequent transfer of immunity to calves. J. Dairy Sci. 88:766-775 crossref(new window)

Fuller, R. 1989. Probiotics in man and animals. J. Appl. Bacteriol. 66:365-378

Heinrichs, A. J., C. M. Jones and B. S. Heinrichs. 2003. Effects of mannan oligosaccharide or antibiotics in neonatal diets on health and growth of dairy calves. J. Dairy Sci. 86:4064-4069

Inokuma, H., T. Yoshida and T. Onishi. 1995. Development of peripheral blood mononuclear cell response to mitogens in Japanese Black newborn calves. J. Vet. Med. Sci. 57:971-972

Jouany, J. P. and D. P. Morgavi. 2007. Use of 'natural' products as alternatives to antibiotic feed additives in ruminant production. Animal 1:1443-1466

Kume, S. and S. Tanabe. 1996. Effect of supplemental lactoferrin with ferrous iron on iron status of newborn calves. J. Dairy Sci. 79:459-464 crossref(new window)

Lash, J. A., T. D. Coates, J. Lafuze, R. L. Baehner and L. A. Boxer. 1983. Plasma lactoferrin reflects granulocyte activation in vivo. Blood 61:885-888

Legrand, D., E. Elass, A. Pierce and J. Mazurier 2004. Lactoferrin and host defense: An overview of its immuno-modulating and anti-inflammatory properties. Biometals 17:225-229 crossref(new window)

Maaks, S., H. Z. Yan and W. G. Wood. 1989. Development and evaluation of luminescence based sandwich assay for plasma lactoferrin as a marker for sepsis and bacterial infections in pediatric medicine. J. Biolumin. Chemilumin. 3:221-226 crossref(new window)

Maatje, K., J. Verhoeff, W. D. Kremer, A. L. Cruijsen and T. S. van den Ingh. 1993. Automated feeding of milk replacer and health control of group-housed veal calves. Vet. Rec. 133:266-270

Macfarlane, S., G. T. Macfarlane and J. H. Cummings. 2006. Prebiotics in the gastrointestinal tract. Review. Aliment. Pharmacol. Ther. 24:701-714 crossref(new window)

Meas, S., T. Usui, K. Ohashi, C. Sugimoto and M. Onuma. 2002. Vertical transmission of bovine leukemia virus and bovine immunodeficiency virus in dairy cattle herds. Vet. Microbiol. 84:275-282 crossref(new window)

Minamida, K., M. Ohashi, H. Hara, K. Asano and F. Tomita. 2006. Effects of ingestion of difructose anhydride III (DFA III) and the DFA III-assimilating bacterium Ruminococcus products on rat intestine. Biosci. Biotechnol. Biochem. 70:332-339 crossref(new window)

Minamida, K., K. Shiga, I. N. Sujaya, T. Sone, A. Yokota, H. Hara, K. Asano and F. Tomita. 2005. Effects of difructose anhydride III (DFA III) administration on rat intestinal microbiota. J. Biosci. Bioeng. 99:230-236 crossref(new window)

Mineo, H., H. Hara, N. Shigematsu, Y. Okuhara and F. Tomita. 2002. Melibiose, difructose anhydride III and difructose anhydride IV enhance net calcium absorption in rat small and large intestinal epithelium by increasing the passage of tight junctions in vitro. J. Nutr. 132:3394-3399

Mitamura, R., H. Hara, Y. Aoyama and H. Chiji. 2002. Supplemental feeding of difructose anhydride III restores calcium absorption impaired by ovariectomy in rats. J. Nutr. 132:3387-3393

Nagy, D. W., J. W. Tyler and S. B. Kleiboeker. 2007. Decreased periparturient transmission of bovine leucosis virus in colostrums-fed calves. J. Vet. Intern. Med. 21:1104-1107 crossref(new window)

Novak, J. and J. A. Katz. 2006. Probiotics and prebiotics for gastrointestinal infections. Curr. Infect. Dis. Rep. 8:103-109 crossref(new window)

Ohtsuka, H., S. Komatsu, S. Kon-nai, S. Fukuda, Y. Kuku, T. Yoshino, M. Koiwa and S. Kawamura. 2002. Comparison of peripheral leukocytes in Japanese Black and Holstein calves. J. Jpn. Vet. Med. Assoc. 55:789-795 (in Japanese, with English abstract)

Radostits, O. M., C. C. Gay, D. C. Blood and K. W. Hinchcliff. 2000a. Diseases of the newborn. Neonatal infection. In: Veterinary Medicine, $9^{th}$ ed. W.B. Saunders Company, Pennsylvania. pp. 134-146

Radostits, O. M., C. C. Gay, D. C. Blood and K. W. Hinchcliff. 2000b. Diseases caused by nutritional deficiencies. Iron deficiency. In: Veterinary Medicine, $9^{th}$ Ed. W.B. Saunders Company, Pennsylvania pp. 1505-1509

Rasmussen, L., M. B. Jensen and L. L. Jeppesen. 2006. The effect of age at introduction and number of milk-portions on the behavior of group housed dairy calves fed by a computer controlled milk feeder. Appl. Anim. Behav. Sci. 100:153-163 crossref(new window)

Reber, A. J., D. C. Donovan, J. Gabbard, K. Galland, M. Aceves-Avila, K. A. Holbert, L. Marshall and D. J. Hurley. 2008. Transfer of maternal colostral leukocyte promotes development of the neonatal immune system Part II. Effects on neonatal lymphocytes. Vet. Immuno. Immunop. 123:305-313 crossref(new window)

Refsdal, A. O. 2000. To treat or not treat: A proper use of hormones and antibiotics. Anim. Reprod. Sci. 60-61:109-119 crossref(new window)

Sato, T., T. Nakai, H. Sadoya, M. Ohtani, M. Hanada and M. Okamoto. 2007. Effect of difructose anhydride III on hypocalcemia in dairy cows after calving. Anim. Sci. J. 78:37-43 (in Japanese, with English abstract) crossref(new window)

Shiga, K., H. Hara, G. Okano, M. Ito, A. Minami and F. Tomita. 2003. Ingestion of difructose anghdride III and voluntary running exercise independently increase femoral and tibial bone mineral density and bone strength with increasing calcium absorption in rats. J. Nutr. 123:4207-4211

Shigematsu, N., Y. Okuhara, T. Shiomi, F. Tomita and H. Hara. 2004. Effect of difructose anhydride III on calcium absorption in humans. Biosci. Biotechnol. Biochem. 68:1011-1016 crossref(new window)

Svensson, C. and P. Liberg. 2006. The effect of group size on health and growth rate of Swedish dairy calves housed in pens with automatic milk-feeders. Prev. Vet. Med. 73:43-53 crossref(new window)

Swan, H., S. Godden, R. Bey, S. Wells, J. Fetrow and H. Chester-Jones. 2007. Passive transfer of immunoglobulin G and preweaning health in Holstein calves fed a commercial colostrums replacer. J. Dairy Sci. 90:3857-3866 crossref(new window)

Talukder, M. J., T. Takeuchi and E. Harada. 2003. Receptormediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves. J. Vet. Med. Sci. 65:957-964 crossref(new window)

Tamura, A., T. Shiomi, N. Tamaki, N. Shigematsu, F. Tomita and H. Hara. 2004. Comparative effect of repeated ingestion of difructose anhydride III and palatinose on the induction of gastrointestinal symptom in human. Biosci. Biotechnol. Biochem. 68:1882-1887 crossref(new window)

Teraguchi, S., H. Wakabayashi, H. Kuwata, K. Yamauchi and Y. Tamura. 2004. Protection against infections by oral lactoferrin: Evaluation in animal models. Biometals 17:231-234 crossref(new window)

Timmerman, H. M., L. Mulder, H. Everts, D. C. van Espen, E. van der Wal, G. Klaassen, S. M. Rouwers, R. Hartemink, F. M. Rombouts and A. C. Beynen. 2005. Health and growth of veal calves fed milk replacers with or without probiotics. J. Dairy Sci. 88:2154-2165 crossref(new window)

Tomita, K., T. Shiomi, Y. Okuhara, A. Tamura, N. Shigematsu and H. Hara. 2007. Ingestion of difructose anhydride III enhances absorption and retention of calcium in healthy men. Biosci. Biotechnol. Biochem. 71:681-687 crossref(new window)

Wenk, C. 2000. Recent advances in animal feed additives such as metabolic modifiers, antimicrobial agents, probiotics, enzymes and highly available minerals. Review. Asian-Aust. J. Anim. Sci. 13:86-95

Wittum, T. E. and L. J. Perino. 1995. Passive immune status at postpartum hour 24 and long-term health and performance of calves. Am. J. Vet. Res. 56:1149-1154 crossref(new window)

Yamauchi, K., H. Wakabayashi, S. Hashimoto, S. Teraguchi, H. Hayasawa and M. Tomita. 1998. Effect of orally administered bovine lactoferrin on the immune system of healthy volunteers. Adv. Exp. Med. Biol. 443:261-265

Yokota, A., S. Hirayama, K. Enomoto, Y. Miura and F. Tomita. 1991. Production of inulin fructotransferase (de-polymerizing) by Arthrobacter sp. H65-7 and preparation of DFA III from inulin by the enzyme. J. Ferment. Bioeng. 72:258-261 crossref(new window)