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The Endocrine Regulation of Chicken Growth
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 Title & Authors
The Endocrine Regulation of Chicken Growth
Kim, Jin-Wook;
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The somatotropic axis plays a key role in proliferation and differentiation of avian organs during both pre- and posthatching periods. This review discusses the complexity of regulation of the endocrine system for chicken development and growth by growth hormone (GH), insulin-like growth factor (IGF), and IGF binding protein (IGFBP). In addition, the thyrotropic axis, including thyrotropin-releasing hormone (TRH) and thyroid hormones ( and ), is also involved in the GH-secreting pattern. In mammals, IGFI and -II are always sequestered in a 150 kDa non-covalent ternary complex. This complex consists of one molecule each of IGF-I or IGF-II, IGFBP-3 or IGFBP-5 and an acid labile subunit (ALS). Chick ALS is identified in different strains for the first time, and further investigation of the expression of ALS on developmental stage and ALS effect on IGF bioavailability may be addressed in the future.
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Agarwal, S. K., L. A. Cogburn and J. Burnside. 1994. Dysfunctional growth hormone receptor in a strain of sexlinked dwarf chicken: evidence for mutation in the intracellular domain. J. Endocrinol. 142:427-434. crossref(new window)

Armstrong, D. G. and C. O. Hogg. 1994. Type-I insulin like growth factor receptor gene expression in the chick: Developmental changes and the effect of selection for increased growth on the amount of receptor mRNA. J. Mol. Endocrinol. 12:3-12. crossref(new window)

Ballard, F. J., R. J. Johnson, P. C. Owen, G. L. Francis, F. M. Upton, J. P. McMurtry and J. C. Wallace. 1990. Chicken insulin-like growth factor-I: Amino acid sequence, radioimmunoassay, and plasma levels between strains and during growth. Gen. Comp. Endocrinol. 79:459-468. crossref(new window)

Bassas, L., F. De Pablo, M. A. Lesniak and J. Roith. 1987. The insulin receptors of chick embryo show tissue specific structural differences which parallel those of the insulin -like growth factor-I receptors. Endocrinology 121:1468-1476. crossref(new window)

Binoux, M. and P. Hossenlopp. 1988. Insulin-like growth factor (IGF) and IGF-binding proteins: comparison of human serum and lymph. J. Clin. Endocrinol. Metab. 67:509-514. crossref(new window)

Boisclair, Y. R., D. Seto, S. Hsieh, K. R. Hurst and G. T. Ooi. 1996. Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc. Natl. Acad. Sci. USA 93:10028-10033. crossref(new window)

Burch, W. M. and H. E. Lebovitz. 1982. Triiodothyronine stimulation of in vitro growth and maturation of embryonic chick cartilage. Endocrinology 111:462-468. crossref(new window)

Burch, W. M. and J. J. Van Wyk. 1987. Triiodothyronine stimulates cartilage growth and maturation by different mechamism. Am. J. Physiol. 252:E176-182.

Burnside, J. and L. A. Cogburn. 1992. Developmental expression of hepatic growth hormone receptor and insulin-like growth factor-I mRNA in the chicken. Mol. Cell. Endocrinol. 89:91-96. crossref(new window)

Burnside, J., S. S. Liou and L. A. Cogburn. 1991. Molecular cloning of the chicken growth receptor complementary deoxyribonucleic acid: mutation of the gene in sex-linked dwarf chickens. Endocrinology 128:3183-3192. crossref(new window)

Butler, J. H. and P. D. Gluckman. 1986. Circulating insulin-like growth factor-binding proteins in fetal, neonatal and adult sheep. J. Endocrinol. 109:333-338. crossref(new window)

Butterwith, S. C. and C. Goddard. 1991. Regulation of DNA synthesis in chicken adipocyte precursor cells by insulin-like growth factors, platelet-derived growth factor and transforming growth $factor-{beta}$. J. Endocrinol. 131:203-209. crossref(new window)

Caldes, J., J. Alemany, H. L. Robcis and F. De Pablo. 1991. Expression of insulin-like growth factor I in developing lens is compartmentalized. J. Biol. Chem. 266:20786-20790.

Chin, E., J. Zhou, J. Dai, R. C. Baxter and C. A. Bondy. 1994. Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex. Endocrinology 134:2498-2504. crossref(new window)

Cogburn, L. A. 1991. Endocrine manipulation of body composition in broiler chicken. Cirt. Rev. Poult. Biol. 3:283-305.

Cogburn, L. A., J. Burnside and C. G. Scanes. 2000. Physiology of growth and development. Sturkie's avian physiology (5th ed.). Academic press.

Cogburn, L. A., N. C. Mao, S. Agarwal and J. Burnside. 1995. Interaction between somatotropic and thyrotropic axes in regulation of growth and development of broiler chickens. Arch. Geflugel. Sonderch. 1:18-21.

Cogburn, L. A., S. S. Liou, A. L. Rand and J. P. McMurtry. 1989. Growth, metabolic and endocrine responses of broiler cockerels given a daily subcutaneous injection of natural or biosynthetic chicken growth hormone. J. Nutr. 119:1213-1222.

Conlon, M. A. and L. Kita. 2002. Muscle protein synthesis rate is altered in response to a single injection of insulin-like growth factor-I in seven-day-old Leghorn chicks. Poult. Sci. 81:1543-1547. crossref(new window)

Cynober, L., C. Aussel, P. Chatelian, M. Vaubourdolle, J. Agneray and O. G. Ekindjian. 1985. Insulin-like growth factor I/somatomedin C action on 2-deoxyglucose and a-amino isobutyrate uptake in chick embryo fibroblasts. Biochimie 67:1185-1190. crossref(new window)

Dai, J. and R. C. Baxter. 1992. Molecular cloning of the acidlabile subunit of the rat insulin-like growth factor binding protein complex. Biochem. Biophys. Res. Commun. 188:304-209. crossref(new window)

Dai, J. and R. C. Baxter. 1994. Regulation in vivo of the acid-labile subunit of the rat serum insulin-like growth factor-binding protein complex. Endocrinology 135:2335-2341. crossref(new window)

Darras, V. M., M.-F. Finne, L. R. Berghman and E. R. Kuhn. 1994. Ontogrny of the sensitivity of the somatotrophs to TRH and growth hormone-releasing factor (GRF) in the embryonic and post-hatch chick. Ann d'Endocrinol (Paris) 55:255-260.

Daughaday, W. H., M. Kapadia, C. E. Yanow, K. Fabrick and I. K. Mariz. 1985. Insulin-like growth factor I and IGF II of nonmammalian sera. Gen. Comp. Endocrinol. 59:316-325. crossref(new window)

Dean, C. E., M. Piper and T. E. Porter. 1997. Differential responsiveness of somatotrophs to growth hormone-releasing hormone and thyrotropin-releasing hormone during chicken embryonic development. Mol. Cell. Endocrinol. 132:33-41. crossref(new window)

De Groef, B., S. V. H. Grommen and V. M. Darras. 2008. The chicken embryo as a model for developmental endocrinology; development of the thyrotropic, corticotropic and somatotropic axes. Mol. Cell. Endocrinol. 293:17-24. crossref(new window)

De Pablo, F., V. B. Perez, J. Serna and G. P. R. Gonzalez. 1993. IGF-I and the IGF-I receptor in development of nonmammalian vetebrates. Mol. Reprod. Dev. 35:427-432. crossref(new window)

Duclos, M. J. and C. Goddard. 1990. Insulin-like growth factor receptor in chicken liver membranes: Binding properties, specificity, developmental pattern and evidence for a single receptor type. J. Endocrinol. 125:199-206. crossref(new window)

Duclos, M. J., R. S. Wilkie and C. Goodard. 1991. Stimulation of DNA synthesis in chicken muscle satellite cells by insulin and insulin-like growth factors: evidence for exclusive mediation by a type-I insulin-like growth factor receptor. J. Endocrinol. 128:35-42. crossref(new window)

Edens, A. and F. Talamantes. 1998. Alternative processing of growth hormone receptor transcripts. Endocr. Rev. 19:559-582. crossref(new window)

Firth, S. M., U. Ganeshprasad and R. C. Baxter. 1998. Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3. J. Biol. Chem. 273:2631-2638. crossref(new window)

Frawley, L. S., J. P. Hoeffler and F. R. Boockfor. 1985. Functional maturation of somatotropes in fetal rat pituitaries: analysis by reverse hemolytic plaque assay. Endocrinology 116:2355-2360. crossref(new window)

Geris, K. L., L. R. Berghman, E. R. Kuhn and V. M. Darras. 1998. Pre- and post-hatch developmental changes in hypothalamic thytrotropin-releasing hormone and somatostatin concentrations and in circulating growth hormone and thyrotropin levels in the chicken. J. Endocrinol. 219-225.

Goddard, C., R. S. Wilkie and I. C. Dunn. 1988. The relationship between insulin like growth factor-I, growth hormone, thyroid hormones, and insulin in chickens selected for growth. Domest. Anim. Endocrinol. 5:165-176. crossref(new window)

Harvey, S., T. F. Davidson and A. Chadwick. 1979. Ontogeny of growth hormone and prolactin secretion in the domestic fowl (Gallus Domesticus). Gen. Com. Endocrinol. 39:270-273. crossref(new window)

Haselbacher, G. K., R. Y. Andres and R. E. Humbel. 1980. Evidence for the synthesis of a somatomedin similar to insulinlike growth factor I by chick embryo liver cells. Eur. J. Biochem. 111:245-250.

Holzenberger, M., F. Lapointe, M. Leibovici and C. Ayer-Le Lievre. 1996. The avian IGF type I receptor: cDNA analysis and in situ hybridization reveal conserved sequence elements and expression patterns relevant for the development of the nervous system. Dev. Brain Res. 97:76-87. crossref(new window)

Huybrechts, L. M., E. Decuypere, C. G. Scanes, P. Callewaert, E. Peys and E. R. Kuhn. 1985. Human pancreatic growth hormone releasing factor stimulates growth hormone secretion in perinatal dwarf and control chickens. Horm. Metab. Res. 17:690-691. crossref(new window)

Huybrechts, L. M., R. Michielsen, V. M. Darras, F. C. Buonomo, E. R. Kuhn and E. Decuypere. 1989. Effect of the sex-linked dwarf gene on thyrotropic and somatotropic axes in the chick embryo. Reprod. Nutr. Dev. 29:219-226. crossref(new window)

Janosi, J. B., P. A. Ramsland, M. R. Mott, S. M. Firth, R. C. Baxter and P. J. Delhanty. 1999. The acid-labile subunit of the serum insulin-like growth factor-binding protein complexes. Structural determination by molecular modeling and electron microscopy. J. Biol. Chem. 274:23328-23332. crossref(new window)

Johnson, R. J., J. P. McNurtry and F. J. Ballard. 1990. Ontogeny and secretory patterns of plasma insulin-like growth factor-I concentrations in meat-type chickens. J. Endocrinol. 124:81-87. crossref(new window)

Kallincos, N. C., J. C. Wallace, G. L. Francis and F. J. Ballard. 1990. Chemical and biological characterization of chicken insulin-like growth factor-II. J. Endocrinol. 124:89-97. crossref(new window)

Kikuchi, K., F. C. Buonomo, Y. Kajimoto and P. Rotwein. 1991. Expression of insulin-like growth factor-I during chicken developemnt. Endocrinology 128:1323-1328. crossref(new window)

Kim, J. W. and Y. R. Boisclair. 2008. Growth hormone signaling in the regulation of acid labile subunit. Asian-Aust. J. Anim. Sci. 21:754-768. crossref(new window)

Kim, J. W., R. P. Rhoads, N. Segoale, N. B. Kristensen, D. E. Bauman and Y. B. Boisclair. 2006. Isolation of the cDNA encoding the acid labile subunit (ALS) of the 150 kDa IGFbinding protein complex in cattle and ALS regulation during the transition from pregnancy to lactation. J. Endocrinol. 189:583-593. crossref(new window)

King, D. B. and C. R. King. 1973. Thyroidal influence on early muscle growth chickens. Gen. Comp. Endocrinol. 21:517-529. crossref(new window)

King, D. B. and C. R. King. 1976. Thyroidal influence on gastrocinemus and sartorius muscle growth in young White Leghorn cockerels. Gen. Comp. Endocrinol. 29:473-479. crossref(new window)

Kita, K., F. M. Tomas, P. C. Owen, S. E. Knowles, B. E. Forbes, Z. Uptons, R. Hughes and F. J. Ballard. 1996. Influence of nutrition on hepatic IGF-I mRNA levels and plasma concentration of IGF-I and IGF-II in meat-type chickens. J. Endocrinol. 149:181-190. crossref(new window)

Kita, K., K. Nagao, N. Taneda, Y. Inagaki, K. Hirano, T. Shibata, M. A. Yaman, M. A. Conlon and J-I. Okumura. 2002. Insulinlike growth factor binding protein-2 gene expression can be regulated by diet manipulation in several tissues of young chickens. J. Nutr. 132:145-151.

Kuhn, E. R. 1993. Role of growth hormone in thyroid function of vertebrates. Academiae Analecta 55:3-13.

Kuhn, E. R., L. M. Huybrechts, A. Vanderpooten and L. Berghman. 1989. A decreased capacity of hepatic growth hormone (GH) receptors and failure of thyrotrophin-releasing hormone to stimulate the peripheral conversion of thyroxine into triiodothyronine in sex-linked dwarf broiler hens. Reprod. Nutr. Dev. 29:461-467. crossref(new window)

Kuhn, E. R., L. Vleurick, M. Edery, E. Decuypere and V. M. Darras. 2002. Internalization of the chicken growth hormone receptor complex and its effect on biological functions. Com. Biochem. Physiol. 132:299-308. crossref(new window)

Kuhn, E. R., S. M. E. Geelissen, S. Van der Geyten and V. M. Darras. 2005. The release of growth hormone (GH): releation to the thyrotrophic- and Corticotropic axis in the chicken. Domest. Anim. Endocrinol. 29:43-51. crossref(new window)

Lazarus, D. D. and C. G. Scanes. 1988. Acute effects of hypophysectomy and administration of pancreatic and thyroid hormones on circulating concentrations of somatomedin-C and young chickens: relationship between growth hormone and somatomedin-C. Domest. Anim. Endocrinol. 5:283-289. crossref(new window)

Leach, R. M. and G. E. Rosselot. 1992. The use of avian epiphyseal chondrocytes for in vitro studies of skeletal metabolism. J. Nutr. 122:802-805.

Leach, R. M., M. P. Richards, C. A. Praul, B. C. Ford and J. P. McMurtry. 2006. Investigation of the insulin-like growth factor system in the avian epiphyseal growth plate. Domest. Anim. Endocrinol. 33:143-153.

Lee, C. Y., I. Kwak, C. S. Chung, W. S. Choi, R. C. Simmen and F. A. Simmen. 2001. Molecular cloning of the porcine acid-labile subunit (ALS) of the insulin-like growth factor-binding protein complex and detection of ALS gene expression in hepatic and non-hepatic tissues. J. Mol. Endocrinol. 26:135-144. crossref(new window)

Leong, S. R., R. C. Baxter, T. Camerato, J. Dai and W. I. Wood. 1992. Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. Mol. Endocrinol. 6:870-876. crossref(new window)

Leung, F. C., J. E. Taylor and A. Van Iderstine. 1984. Effects of dietary thyroid hormones on growth and serum T3, T4 and growth hormone in sex-linked dwarf chickens. Proc. Soc. Exp. Biol. Med. 177:77-81. crossref(new window)

Lu, F. Z., Z. Y. Jiang, X. X. Wang, Y. H. Luo, X. F. Li and H. L. Liu. 2010. Role of the insulin-like growth factor system in epiphyseal cartilage on the development of Langshan and Arbor Acres chickens, Gallus domesticus. Poult. Sci. 89:956-965. crossref(new window)

Mao, J. N., L. A. Cogburn and J. Burnside. 1997. Growth hormone down-regulates growth hormone receptor mRNA in chickens but developmental increases in growth hormone receptor mRNA occur independently of growth hormone action. Mol. Cell. Endocrinol. 129:135-143. crossref(new window)

Marsh, J. A., T. J. Lauterio and C. G. Scanes. 1984. Effects of triiodothyronine treatments on body and organ growth and the development of immune function in dwarf chickens. Proc. Soc. Exp. Biol. Med. 177:82-91. crossref(new window)

McCann-Levorse, L. M., S. V. Radecki, D. J. Donoghue, S. Malamed, D. N. Foster and C. G. Scanes. 1993. Ontogeny of pituitary growth hormone and growth hormone mRNA in the chicken. Proc. Soc. Exp. Biol. Med. 202:109-113. crossref(new window)

McGuinness, M. C. and L. A. Cogburn. 1990. Measurement of developmental changes in plasma insulin-like growth factor-I levels of broiler chickens by radioreceptor assay and radioimmunireceptor assay. Gen. Comp. Endocrinol. 79:446-458. crossref(new window)

McMurtry J. P., G. L. Francis and Z. Upton. 1997. Insulin-like growth factors in poultry. Dom. Anim. Endocrinol. 14:199-229. crossref(new window)

Mohan, S. and D. J. Baylink. 2002. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J. Endocrinol. 175:19-31. crossref(new window)

Moore, G. E., S. Harvey, H. Klandorf and G. Goldspink. 1984. Muscle development in thyroidectomized chickens (Gallus domesticus). Gen. Comp. Endocrinol. 55:195-199. crossref(new window)

Morishita, D., M. Sasaki, M. Wakita and S. Hoshino. 1996. Effect of fasting on serum insulin-like growth factor-I (IGF-I) levels and IGF-binding activity in cockerels. J. Mol. Endocrinol. 139:363-370.

Morishita, D., M. Wakita and S. Hoshino. 1993. Effect of hypophysectomy on insulin-like growth factor (IGF)-I binding activity of serum in chickens. Comp. Biochem. Physiol. 104A:261-265.

Oldham, E. R., B. Bingham and W. R. Baumbach. 1993. A functional polyadenylation signal is embedded in the coding region of chicken growth hormone receptor RNA. Mol. Endocrinol. 7:1379-1390. crossref(new window)

O'Neill, I. E., B. Houston and C. Goddard. 1990. Stimulation of insulin-like growth factor I production in primary cultures of chicken hepatocytes by chicken growth hormone. Mol. Cell. Endocrinol. 70:41-47. crossref(new window)

Ooi, G. T., K. R. Hurst, M. N. Poy, M. M. Rechler and Y. B. Boisclair. 1998. Binding of STAT5a and STAT5b to a single element resembling a gamma- interferon-activated sequence mediates the growth hormone induction of the mouse acidlabile subunit promoter in liver cells. Mol. Endocrinol. 12:675- 687. crossref(new window)

Piper, M. M. and T. E. Porter. 1997. Responsiveness of chicken embryonic somatotrophs to somatostatin (SRIF) and IFG-I. J. Endocrinol. 154:303-310. crossref(new window)

Porter, T. E. 2005. Regulation of pituitary somatotroph differentiation by hormones of peripheral endocrine gland. Domest. Anim. Endocrinol. 29:52-62. crossref(new window)

Porter, T. E., G. S. Couger, C. E. Dean and B. M. Hargis. 1995. Ontogeny of growth hormone (GH)-secreting cells during chicken embryonic development: initial somatotrophs are responsive to GH-releasing hormone. Endocrinol. 136:1850-1856. crossref(new window)

Proudman, J. A., M. C. McGuinness, K. A. Krishnan and L. A. Cogburn. 1994. Endocrine and metabolic responses of intact and hypophysectomized turkey poults given a daily injection of chicken growth hormone. Comp. Biochem. Physiol. 109C:47-56.

Radecki, S. V., M. C. Capdevielle, F. C. Buonomo and C. G. Scanes. 1997. Ontogeny of insulin-like growth factor (IGF-I and IGF-II) and IGF-binding proteins in the chicken following hatching. Gen. Comp. Endocrinol. 107:109-117.

Rhoads, R. P., P. L. Greenwood, A. W. Bell and Y. B. Boisclair. 2000. Organization and regulation of the gene encoding the sheep acid-labile subunit of the 150-kilodalton insulin-like growth factor-binding protein complex. Endocrinology 141:1425-1433. crossref(new window)

Rosebrough, R. W. and J. P. McMurtry. 2003. Methimazole and thyroid hormone replacement in broilers. Domest. Anim. Endocrinol. 24:231-242. crossref(new window)

Rosselot, G., J. P. McMurtry, R. Vasilatos-Younken and S. Czerwinski. 1995. Effect of exogenous chicken growth hormone (cGH) administration on insulin-like growth factor-I (IGF-I) gene expression in domestic fowl. Mol. Cell. Endocrinol. 114:157-166. crossref(new window)

Scanes, C. G. 2009. Perspectives on the endocrinology of poultry growth and metabolism. Gen. Com. Endocrinol. 163:24-32. crossref(new window)

Scanes, C. G., D. R. Duyka, T. J. Lauterio, S. J. Bowen, L. M. Huybrechts, W. L. Bacon and D. B. King. 1986. Effect of chicken growth hormone, triiodothyronine and hypophysectomy in growing domestic fowl. Growth 50:12-31.

Scanes, C. G., J. Marsh, E. Decuypere and P. Rudas. 1983. Abnormalities in the plasma concentrations of thyroxine, triiodothyronine and growth hormone in sex-linked dwarf and autosomal White Leghorn domestic fowl (Gallus domesticus). J. Endocrinol. 97:127-135. crossref(new window)

Serrano, J., A. R. Shuldiner, C. T. Roberts, D. LeRoith and F. De Pablo. 1990. The insulin-like growth factor (IGF-I) gene is expressed in chick embryos during early organogenesis. Endocrinology 127:1547-1549. crossref(new window)

Tanaka, M., Y. Hayashida, K. Sakaguchi, T. Ohkubo, M. Wakita, S. Hoshino and K. Nakashima. 1996. Growth hormoneindependent expression of insulin-like growth factor I messenger ribonucleic acid in extrahepatic tissues of the chicken. Endocrinology 137:30-34. crossref(new window)

Thommes, R. C., J. B. Martens, W. E. Hopkins, J. Caliendo, M. J. Sorrentino and J. E. Woods. 1983. Hypothalamoadenohypophyseal- thyroid interrelationships in the chick embryo. IV. Immunocytochemical demonstration of TSH in the hypophyseal pars distalis. Gen. Comp. Endocrinol. 51:434-443. crossref(new window)

Tixier-Boichard, M., L. M. Huybrechts, E. Becuypere, E. R. Kuhn, J. L. Monvoisin, G. Coquerelle, J. Charrier and J. Simon. 1992. Effects of insulin-like growth factor I (IGF-I) infusion and dietary tri-iodothyronine (T3) supplementation on growth, body composition and plasma hormone levels in sex-linked dwarf mutant and normal chickens. J. Endocrinol. 133:101-110. crossref(new window)

Tomas, F. M., R. A. Pym, J. P. McMurtry and G. L. Francis. 1998. Insulin-like growth factor (IGF)-I but not IGF-II promotes lean growth and feed efficiency in broiler chickens. Gen. Comp. Endocrinol. 110:-275.

Tsukada, A., T. Ohkubo, K. Sakaguchi, M. Tanaka, K. Nakashima, Y. Hayashida, M. Wakita and S. Hoshino. 1998. Thyroid hormones are involved in insulin-like growth factor-I (IGF-I) production by stimulating hepatic growth hormone receptor (GHR) gene expression in the chicken. Growth Horm. IGF Res. 8:235-242. crossref(new window)

Twigg, S. M. and R. C. Baxter. 1998. Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit. J. Biol. Chem. 273:6074-6079. crossref(new window)

Twigg, S. M., M. C. Kiefer, J. Zapf and R. C. Baxter. 1998. Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain. J. Biol. Chem. 273:28791-28798. crossref(new window)

Ueki, I, S. L. Giesy, K. J. Harvatine, J. W. Kim and Y. R. Boisclair. 2009. The acid-labile subunit is required for full effects of exogenous growth hormone on growth and carbohydrate metabolism. Endocrinology 150:3145-3152. crossref(new window)

Ueki, I., G. T. Ooi, M. L. Tremblay, K. R. Hurst, L. A. Bach and Y. B. Boisclair. 2000. Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system. Proc. Natl. Acad. Sci. USA 97:6868-6873. crossref(new window)

Vanderpooten, A., L. M. Huybrechts, P. Rudas, E. Decuypere and E. R. Kuhn. 1991a. Differences in hepatic growth hormone receptor binding during development of normal and dwarf chickens. Reprod. Nutr. Dev. 31:47-55. crossref(new window)

Vanderpooten, A., V. M. Darras, L. M. Huybrechts, P. Rudas, E. Decuypere and E. R. Kuhn. 1991b. Effect of hypophysectomy and acute administration of growth hormone (GH) and GHreceptor binding in chick liver membranes J. Endocrinol. 129:275-281. crossref(new window)

Vanderpooten, A., W. Janssens, J. Buyse, F. Leenstra, L. Berghman, E. Decuypere and E. R. Kuhn. 1993. Study of the hepatic growth hormone (GH) receptor at different ages in chickens selected for a good feed converson (FC) and a fast weight gain (GL.) Dom. Anim. Endocrinol. 10:199-206. crossref(new window)

Vasilatos-Younken, R., K. S. Gray, W. L. Bacon, K. E. Nestor, D. W. Long and J. L. Rosenberger. 1990. Ontogeny of growth hormone (GH) binding in the domestic turkey:evidence of sexual dimorphism and developmental changes in relationship to plasma GH. J. Endocrinol. 126:131-139. crossref(new window)

Vasilatos-Younken, R., T. L. Cravener, L. A. Cogburn, M. G. Mast and R. H. Wellenreiter. 1988. Effect of pattern of administration on the response to exogenous, pituitary-derived chicken growth hormone by broiler-strain pullets. Gem. Comp. Endocrinol. 71:268-283. crossref(new window)

Vasilatos-Younken, R., X. H. Wang, Y. Zhou, J. R. day, J. P. McNurtry, R. W. Rosenbrough, E. Decuypere, N. Buys, V. Darras, J. L. Beard and F. Tomas. 1999. New insights into the mechanism and actions of growth hormone (GH) in poultry. Domest. Anim. Endocrinol. 17:181-190. crossref(new window)