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Effect of Corticosterone Administration on Small Intestinal Weight and Expression of Small Intestinal Nutrient Transporter mRNA of Broiler Chickens
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Effect of Corticosterone Administration on Small Intestinal Weight and Expression of Small Intestinal Nutrient Transporter mRNA of Broiler Chickens
Hu, X.F.; Guo, Yuming; Huang, B.Y.; Zhang, L.B.; Bun, S.; Liu, D.; Long, F.Y.; Li, J.H.; Yang, X.; Jiao, P.;
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The effects of corticosterone (CORT) administration on the weight of small intestine and the expression of nutrient transporter mRNA in the small intestine of broiler chickens (Gallus gallus domesticus) were investigated. One hundred and eight sevenday-old birds were randomly divided into two equal groups comprising a control group (CTRL) and an experimental group (CORT). CTRL birds were fed a basal diet and the CORT birds were fed a basal diet containing 30 mg corticosterone/kg from d 8 to 21. At 21 d of age, average daily feed intake (ADFI), serum corticosterone level, small intestinal absolute wet weight and relative weight, and relative abundance of SGLT1, CaBP-D28k, PepT1 mRNA in the duodenum and L-FABP mRNA in the jejunum were determined. The results showed that serum corticosterone level, liver weight and small intestinal relative weight (small intestinal wet weight/body weight) of CORT chickens were about 30.15%, 26.72% and 42.20% higher, respectively, than in the CTRL group (p<0.05). CORT birds had relative mRNA abundance of CaBP-D28k and PepT1 in the duodenum, and L-FABP in the jejunum which was 1.77, 1.37 and 1.94 fold higher, respectively, than in the CTRL group (p<0.05); the relative abundance of SGLT1 was 1.67 fold higher than in the CTRL group (p = 0.097). ADFI, small intestinal wet weight and length in CORT-treated broiler chickens was about 29.11%, 31.12% and 12.35% lower, respectively, than in the CTRL group (p<0.05). In conclusion, corticosterone administration lowered the wet weight but increased the relative weight of the small intestine and the expression of intestinal nutrient transporter mRNA of broiler chickens.
Broiler Chickens;Corticosterone;Nutrient Transporter;Small Intestine;Stress;
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한국수정란이식학회지, 2014. vol.29. 1, pp.7-12 crossref(new window)
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Banaszak, L., N. Winter and Z. Xu. 1994. Lipid-binding protein: a family of fatty acid and retinoid transport protein. Adv. Protein Chem. 45:89-151 crossref(new window)

Bottje, W. G. and P. C. Harrison. 1985. The effect of tap water carbonated. Poult. Sci. 64:107

Bronner, F. 1987. Intestinal calcium absorption: Mechanisms and applications. J. Nutr. 117:1347-1352

Chance, W. T., T. Foley-Nelson, I. Thomas and A. Balasubramaniam. 1997. Prevention of parenteral nutritioninduced gut hypoplasia by coinfusion of glucagon-like peptide-2. Am. J. Physiol. 273:G559-G563

Covasa, M. and J. M. Forbes. 1995. Selection of foods by broiler chickens following corticosterone administration. Br. Poult. Sci. 36:489-501 crossref(new window)

Craviso, G. L., K. P. Garrett and T. L. Clemens. 1987. 1, 25-Dihydroxy vitamin D3 induces the synthesis of vitamin Ddependent calcium-binding protein in cultured chick kidney cells. Endocrinology 120:894-902 crossref(new window)

Daniel, H. 2004. Molecular and integrative physiology of intestinal peptide transport. Annu. Rev. Physiol. 66:361-384 crossref(new window)

Davis, K. W., A. Cepeda-Benito, J. H. Harraid and P. J. Wellman. 2005. Plasma corticosterone in the rat in response to nicotine and saline injections in a context previously paired or unpaired with nicotine. Psychopharmacology 180:466-472 crossref(new window)

Dibner, J. J., M. L. Kitchell, C. A. Atwell and F. J. Ivey. 1996. The effects of dietary ingredients and age on the microscopic structure of the gastrointestinal tract in poultry. J. Appl. Poult. Res. 5:70-77

Dudley, M. A., L. J. Wykes, A. W. Dudley, JR., D. G. Burrin, B. L. Nichols, J. Rosenberger, F. Jahoor, W. C. Heird and P. J. Reeds. 1998. Parenteral nutrition selectively decreases protein synthesis in the small intestine. Am. J. Physiol. 274:G131- G137

Gal-Garber, O., S. J. Mabjeesh, D. Sklan and Z. Uni. 2000. Partial sequence and expression of the gene forand activity of the sodium glucose transporter in the small intestine of fed, starved and refed chickens. J. Nutr. 130:2174-2179

Garriga, C., M. Moreto and J. M. Planas. 2000. Effects of resalination on intestinal glucose transport in chickens adapted to low $Na^+$ intakes. Exp. Physiol. 85:371-378 crossref(new window)

Garriga, C., C. M. Vazquez, V. Ruiz-Gutierrez and J. M. Planas. 2002. Regional differences in transport, lipid composition and fluidity of apical membranes of small intestine of chicken. Poult. Sci. 81:537-545

Hansen, K. K., M. M. Beck, S. E. Scheideler and E. E. Blankenship. 2004. Exogenous estrogen boosts circulating estradiol concentrations and calcium uptake by duodenal tissue in heat-stressed hens. Poult. Sci. 83:895-900

Howard, T., R. A. Goodlad, J. R. F. Walters, D. Ford and B. H. Hirst. 2004. Increased expression of specific intestinal amino acid and Peptide transporter mRNA in rats fed by TPN is reversed by GLP-2. J. Nutr. 134:2957-2964

Hu, X. F. and Y. M. Guo. 2008. Corticosterone administration alters small intestinal morphology and function of broiler chickens. Asian- Aust. J. Anim. Sci. 21:1773-1778

Ihara, T., T. Tsujikawa, Y. Fujiyama and T. Bamba. 2000. Regulation of PepT1 Peptide Transporter expression in the rat's small intestine under malnourished conditions. Digestion 61:59-67 crossref(new window)

Kellett, G. L. 2001. The facilitated component of intestinal glucose absorption. J. Physiol. 531:585-595 crossref(new window)

Lin, H., E. Decuypere and J. Buyse. 2004a. Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus) 1. Chronic exposure. Comp. Biochem. Physiol. 139B:737-744 crossref(new window)

Lin, H., E. Decuypere and J. Buyse. 2004b. Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus) 2. Short-term effect. Comp. Biochem. Physiol. 139B:745-751 crossref(new window)

Lin, H., S. J. Sui, H. C. Jiao, K. J. Jiang, J. P. Zhao and H. Dong. 2007. Effects of diet and stress mimicked by corticosterone administration on early postmortem muscle metabolism of broiler chickens. Poult. Sci. 86:545-554

Lin, H., S. J. Sui, H. C. Jiao, J. Buyse and E. Decuypere. 2006. Impaired development of broiler chickens by stress mimicked by corticosterone exposure. Comp. Biochem. Physiol. 143A: 400-405 crossref(new window)

Malheiros, R. D., V. M. B. Moraes, A. Collin, E. Ddcuypere and J. Buyse. 2003. Free diet selection by broilers as influenced by dietary macronutrient ratio and Corticosterones supplementation. 1. Diet selection, organ weights, and plasma metabolites. Poult. Sci. 82:123-131

Mickey, A. L., S. A. Laiche, J. R. Thompson, A. L. Pond and E. D. Peebles. 1996. Continuous infusion of adrenocorticotropin elevates circulating lipoprotein, cholesterol and corticosterone concentrations in chickens. Poult. Sci. 75:1428-1432

Mitchell, M. A. and A. J. Carlisle. 1992. The effect of chronic exposure to elevated environmental temperature on intestinal morphology and nutrient absorption in the domestic fowl (Gullus domesticus). Comp. Biochem. Physiol. 101A:137-142 crossref(new window)

Moberg, G. P. and J. A. Mench. 2000. The biology of animal stress: Basic principlies and implications for animal welfare. CABI Publishing, Wallingford, UK, New York, NY, USA. pp. 3-6

Moran, E. T. 1985. Digestion and absorption of carbohydrates in fowl and events through perinatal development. J. Nutr. 115: 665-674

Morrow, L. E., J. L. McClellan, C. A. Conn and M. J. Kluger. 1993. Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am. J. Physiol. 264: R1010-R1016

Naruhashi, K., Y. Sai, I. Tamai, N. Suzuki and A. Tsuji. 2002. PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxial longitudinally in the rat intestine. Pharm. Res. 19:1417-1423 crossref(new window)

Nasir, A., R. P. Moudgal and N. B. Singh. 1999. Involvement of corticosterone in food intake, food passage time and in vivo uptake of nutrients in the chicken (Gallus domesticus). Br. Poult. Sci. 40:517-522 crossref(new window)

Odihambo Mumma, J., J. P. Thaxton, Y. Vizzier-Thaxton and W. L. Dodson. 2006. Physiological stress in laying hens. Poult. Sci. 85:761-769

Ogihara, H., T. Suzuki, Y. Nagamachi, K. I. Inui and K. Takata. 1999. Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acid. Histochem. J. 31:169-174 crossref(new window)

Olanrewaju, H. A., S. Wongpichet, J. P. Thaxton, W. A. Dozier and S. L. Branton. 2006. Stress and acid-base balance in chickens. Poult. Sci. 85:1266-1274

Pan, J., Q. Xiang and S. Ball. 2000. Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver. Drug Metab. Dispos. 28:709-713

Pinheiro, D. F., V. C. Cruz, J. R. Sartori and M. L. M. Vicentini Paulino. 2004. Effect of early feed restriction and enzyme supplementation on digestive enzyme activities in broilers. Poult. Sci. 83:1544-1550

Post, J., J. M. Rebel and A. A. H. M. Ter Huurne. 2003. Physiological effects of elevated plasma corticosterone concentrations in broiler chickens. An alternative means by which to assess the physiological effects of stress. Poult. Sci. 82:1313-1318

Prows, D. R., E. J. Murphy and F. Schroeder. 1995. Intestinal and liver fatty acid-binding proteins differentially affect fatty acid uptake and esterification in L-cell. Lipids 30:907-910 crossref(new window)

Pung, T., K. Zimmerman, B. Klein and M. Ehrich. 2003. Corticosterone in drinking water: altered kinetics of a single oral dose of corticosterone and concentrations of plasma sodium, albumin, globulin, and total protein. Toxicol. Ind. Health 19:171-182 crossref(new window)

Puvadolpirod, S. and J. P. Thaxton. 2000a. Model of physiological stress in chickens 1. Response parameters. Poult. Sci. 79:363- 369

Puvadolpirod, S. and J. P. Thaxton. 2000b. Model of physiological stress in chickens 2. Dosimetry of adrenocorticotropin. Poult. Sci. 79:370-376

Puvadolpirod, S. and J. P. Thaxton. 2000c. Model of physiological stress in chickens 3. Temporal patterns of reponse. Poult. Sci. 79:370-376

Richards, M. P., S. M. Poch, C. N. Coon, R. W. Rosebrough, C. M. Ashwell and J. P. McMurtry. 2003. Feed restriction significantly alters lipogenic gene expression in broiler breeder chickens. J. Nutr. 133:707-715

Spratt, R. S., B. W. McBride, H. S. Bayley and S. Leeson. 1990. Energy metabolism of broiler breeder hens. 2. Contribution of tissues to total heat production in fed and fasted hens. Poult. Sci. 69:1348-1356

Thompson, K. L. and T. J. Applegate. 2006. Feed withdraw alters small-intestinal morphology and mucus of broilers. Poult. Sci. 85:1535-1540

Uni, Z., S. Ganot and D. Sklan. 1998. Post-hatch development of mucosal function in the broiler small intestines. Poult. Sci. 77:75-82

Wasserman, R. H. and C. S. Fullmer. 1995. Vitamin D and intestinal calcium transport: facts, speculation and hypotheses. J. Nutr. 125:1971s-1979s

Wood, S. and P. Frayhum. 2003. Glucose transporters (GLUT and SGLT): expanded families of sugar transport protein. Br. J. Nutr. 89: 3-9

Yamauchi, K., H. Kamisoyama and Y. Isshiki. 1996. Effects of fasting and refeeding on structures of the intestinal villus and epithelial cell in White Leghorn hens. Br. Poult. Sci. 37:909- 921 crossref(new window)

Yamauchi, K. and P. Tarachai. 2000. Change in intestinal villu, cell area and intracellular autophagic vacuoles related to intestinal function in chickens. Br. Poult. Sci. 41:116-123 crossref(new window)

Ziegler, T. R., M. E. Evans, C. Fernandez-Estivariz and D. P. Jones. 2003. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu. Rev. Nutr. 23:229-261 crossref(new window)