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Effects of Astragalus Polysaccharides, Achyranthes bidentata Polysaccharides, and Acantbepanax senticosus Saponin on the Performance and Immunity in Weaned Pigs
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 Title & Authors
Effects of Astragalus Polysaccharides, Achyranthes bidentata Polysaccharides, and Acantbepanax senticosus Saponin on the Performance and Immunity in Weaned Pigs
Kang, P.; Xiao, H.L.; Hou, Y.Q.; Ding, B.Y.; Liu, Y.L.; Zhu, H.L.; Hu, Q.Z.; Hu, Y.; Yin, Y.L.;
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Two trials were conducted to study the effects of two Chinese herbal polysaccharides, Astragalus polysaccharides (APS) and Achyranthes bidentata polysaccharides (ABPS), and one Chinese herbal saponin, Acantbepanax senticosus saponin (ASS), on the immunity and growth performance of weaned pigs. Experiment 1 was a 14-day growth assay, in which 32 weaned pigs were randomly allocated to one of four dietary treatments: i) 0.05% talcum powder control; ii) 0.05% APS; iii) 0.05% mixture of APS and ASS in a 1:1 ratio by weight; and iv) 0.05% mixture of APS, ASS, and ABPS in a ratio of 1:1:1 by weight. Blood samples were collected on day 14 to determine plasma parameters. Feed intake, body weight gain, and feed efficiency were also determined. Experiment 2 was a 21-day immunity assay, in which 16 weaned pigs were randomly allotted to one of two dietary treatments: i) 0.05% talcum powder control; and ii) 0.05% mixture of APS and ASS in a 1:1 ratio by weight. On day 21, pigs were challenged with lipopolysaccharide (LPS) and 3 h later blood samples were collected and analyzed for lymphocyte proliferation as well as interleukin 6 (IL-6), insulin-like growth factor 1 (IGF-1), growth hormone (GH), and cortisol levels. In Experiment 1, feeding Chinese herbal polysaccharides and saponin increased growth performance of the pigs. The effects of the mixture of APS and ASS were especially notable, as there was a significant improvement in growth performance compared with the control (p<0.05). The plasma concentration of immunoglobulin G (IgG), nitric oxide (NO), and nitric oxide synthase (NOS) were increased in all treatments groups, with the mixture of APS and ASS increasing the level of IgG and NOS significantly (p<0.05), compared with the control. There was no difference in the NO level between the control and treatment groups (p>0.05). In Experiment 2, Chinese herbal polysaccharides and saponin showed immunostimulating effects. The level of cortisol, GH, and IGF-I were significantly increased (p>0.05), and the level of IL-6 showed a significant decrease (p<0.05) in the APS and ASS treatment after the LPS challenge. The mixture of APS and ASS could stimulate the blood lymphocyte proliferation significantly whether the LPS was injected or not (p<0.05). These results show that Chinese herbal extracts can improve growth performance and stimulate immunity of weaned pigs. A mixture of APS and ASS, compared with APS alone, could be a new kind of immunostimulant for weaned pigs, which could result in greater positive effects on their growth performance and immunity.
Astragalus Polysaccharides;Achyranthes bidentata Polysaccharides;Acantbepanax senticosus Saponin;Growth Performance;Immunity;Weaned Pigs;
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Alvarez, J. R. and R. Torres-pinedo. 1982. Interactions of soy bean lectin, soyasaponins, and glycinin with rabbit jejunal mucosa in vitro. Pediatr. Res. 16:728-731

Bogdan, C. 1997. Of microbes, macrophages and nitric oxide. Behring Institute Mitteilungen, 58-72

Chen, H. L. 2006. Studies on the extraction, immunomodulating activities of Chinese herbal polysaccharides and approach to the mechanism. Chin. Acad. Agric. Sci. 6:23-25

Chen, H. L., D. F. Li, B. Y. Chang, L. M. Gong, J. G. Dai and G. F. Yi. 2003. Effects of Chinese herbal polysaccharides on the immunity and growth performance of young broilers. Poult. Sci. 82:364-370

Chu, Y. F., X. R. Li and Y. L. Hu. 2004. Effects of Chinese herbal medicinal ingredient on cells mediated immunity in mice. J. Nanjing Agric. Univ. 1:97-100

Cummings, J. H. and G. T. Macfarlane. 2002. Gastrointestinal effects of prebiotics. Br. J. Nutr. 87(Suppl. 2):S145-S151(Abstr.)

Ernest Minton, J. 1994. Function of the hypothalamic-pituitaryadrenal axis and the sympathetic nervous system in models of acute stress in domestic farm animals. J. Anim. Sci. 72:1891-1898

Fan, J., P. E.Molina, M. C. Gelato and C. H. Lang. 1994. Differential tissue regulation of insulin-like growth factor content and binding proteins after endotoxin. J. Endocrinol. 134:1685-1692 crossref(new window)

Fang, F. C. 1997. Perspectives series : Host pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. J. Clin. Invest. 99:2818-2825 crossref(new window)

Figen, Mert-Türk. 2006. Saponins versus plant fungal pathogens. J. Mol. Cell Biol. 5:13-17

Gianotti, L., F. Broglio, G. Ainmartti, E. Arvat, S. Colombo, M. Di Summa, G. Gallioli, G. Pittoni, E. Sardo, M. Stella, C. Miola and E. Ghiqo. 1998. Low IGF-I levels are often uncoupled with elevated GH levels in catabolic conditions. J. Endocrinol. Invest. 21:115-121

Giustina, A. and J. D. Veldhuis. 1998. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr. Rev. 19:717-797 crossref(new window)

Guo, F. C., B. A. Williams, R. P. Kwakkel, H. S. Li, X. P. Li, J. Y. Luo, W. K. Li and M. W. A. Erstegen. 2004. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult. Sci. 83:175-182

Guo, G. L., Y. L. Liu, W. Fan, J. Han, Y. Q. Hou, Y. L. Yin, H. L. Zhu, B. Y. Ding, J. X. Shi, J. Lu, H. R. Wang, J. Chao and Y. H. Qu. 2008. Effects of achyranthes bidentata polysaccharide on growth performance, immunological, adrenal, and somatotropic responses of weaned pigs challenged with Escherichia coli lipopolysaccharide. Asian-Aust. J. Anim. Sci. 21:1189-1195

Harbuz, M. S., A. Stephanou, N. Sarlis and S. L. Lightman. 1992. The effects of recombinant interleukin (IL)-lalpha, IL-lbeta or IL6 on the hypothalamo-pituitary-adrenal axis activation. J. Endocrinol. 133:349-355 crossref(new window)

Hasselgren, P. O. 1993. Protein Metabolism in Sepsis. R. G. Landes Co., Austin, TX.p1-130

Hristov, A. N., S. Zaman, M. Vanderpol, P. Szasz, K. Huber and D. Greer. 2007. Effect of a saponin-based surfactant and aging time on ruminal degradability of flaked corn grain dry matter and starch. J. Anim. Sci. 85:1459-1466 crossref(new window)

Johnson, I. T., J. M. Gee, K. Price, C. Curl and G. R. Fenwick. 1986. Influence of saponins on gut permeability and active nutrient transport in vitro. J. Nutr. 116:2270-2277

Karupiah, G., Q. W. Xie, R. M. Buller, C. Nathan, C. Duarte and J. D. MacMicking 1993. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 261: 1445-1448 crossref(new window)

Kong, X. F., Y. L. Hu, R. Rong, D. Y. Wang and X. R. Li. 2004. Effects of Chinese herbalmedicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. Int. Immunopharmacol. 4:975-982 crossref(new window)

Liang, R., K. K. Guo, L. Yi, Y. X. Zhang, J. Q. Li and Z. Q. Yue. 1998. Study of Chinese herbal medicinal immune stimulator on immune enhancement in chickens. Chinese Journal of Veterinary Science and Technology 28:11-13

Lyons, C. R. 1995. The role of nitric oxide in inflammation. Adv. Immunol. 60:323-371 crossref(new window)

MacMicking, J., Q. W. Xie and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15:323-350 crossref(new window)

Mader, T. L. and M. C. Brumm. 1987. Effect of feeding sarsasaponin in cattle and swine diets. J. Anim. Sci. 65:9-15

Navarra, P., S. Tsagarakis, M. S. Faria, L. H. Rees, G. M. Besser and A. B. Grossman. 1991. Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from the rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. J. Endocrinol. 128:37-44 crossref(new window)

NRC. 1998. Nutrient requirement of swine. Washington, DC. 10th ed. National Academy Press

Okuda, Y., C. W. Bardin and P. L Hodgskin. 1995. Morris. Interleukins-1 alpha and -1 beta regulate interleukin-6 expression in Leydig and Sertoli cells. Recent. Prog. Horm. Res. 50:367-72

Qiu, Y., Y. L. Hu, B. A. Cui, H. Y. Zhang, X. F. Kong, D. Y. Wang, and Y. G. Wang. 2007. Immunopotentiating effects of four Chinese Hherbal polysaccharides administered at vaccination in Chickens. Poult. Sci. 86:2530-2535 crossref(new window)

Rachmilewitz, D., F. Karmeli, E. Okon and M. Bursztyn. 1995. Experimental colitis is ameliorated by inhibition of nitric oxide synthaseactivity. Gut 37:247-255 crossref(new window)

Ribbons, K. A., X.-J. Zhang, J. H. Thompson, S. S. Greenberg, W. M. Moore, C. M. Kornmeier, M. G. Currie, N. Lerche, J. Blanchard, D. A. Clark and M. J. S. 1995. Miller. Potential role of nitricoxide in a model of chronic colitis in rhesus macaques. Gastroenterology 108:705-711 crossref(new window)

Salas, M. A., S. W. Evans, M. J. Level1 and J. T. Whither. 1990 Interleukir-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin. Exp. Immunol. 79:470-473 crossref(new window)

Shin, H. Y., C. H. Shin, T. Y. Shin, E. J. Lee and H. M. Kim. 2003. Effect of bojungikki-tang on lipopolysaccharide-induced cytokine production from peripheral blood mononuclear cells of chronic fatigue syndrome patients. Immunopharmacol Immunotoxicol. 25:491-501 crossref(new window)

Soto, L., A. I. Mart$\'{i}$n, S. Mill$\'{a}$n, E. Vara and A. L$\'{o}$pez-Calder$\'{o}$n. 1998. Effects of endotoxin lipopolysaccharide administration on the somatotropic axis. J. Endocrinol. 159:239-246 crossref(new window)

Stephan, J. P., V. Syed and B. Jegou. 1997. Regulation of Sertoli cell IL-1 and IL-6 production in vitro. Mol. Cell. Endocrinol. 134:109-118 crossref(new window)

Tang, X. M., Y. L. Hu, B. K. Zhang and J. G. Liu. 1998. Effect of astragalus polysaccharide on T lymphocyte transformation function of peripheral blood in chickens. Chin. J. Vet. Sci. 3:269-270 crossref(new window)

Tian, G. Y. and Y. C. Feng. 1994. Progress in the research and application of polysaccharides. Chem. Prog. 6:44-48. (in Chinese)

Tominaga, T., J. Fukata, Y. Naito, T. Usui, N. Murakami, M. Fukushima, Y. Nakai, Y. Hirai and H. Imura. 1991. Prostaglandin-dependent in vitro stimulation of adrenocortical steroidogenesis by interleukins. J. Endocrinol. 128:526-531 crossref(new window)

Wallace, K., MacNaughton, Sonya, S. Lowe and Kelly Cushing. 1998. Role of nitric oxide in inflammation-induced suppression of secretion in a mouse model of acute colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 275:1353-1360

Woloski, B. M., E. M. Smith, W. J. Meyer, G. M. Fuller and J. E. Blalock. 1985 Corticotropin-releasing activity of monokines. Science 230:1035-1037 crossref(new window)

Xie, K., Z. Dong and I. J.Fidler. 1996. Activation of nitric oxide synthase gene for inhibition of cancer metastasis. J. Leukoc. Biol. 59:797-803

Xue, M. and X. S. Meng. 1996. Review on research progress and prosperous of immune activities of bio-active polysaccharides. J. Tradit. Chin. Vet. Med. 3:15-18