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Relationships between Methionine Supply, Nitrogen Retention and Plasma Insulin-like Growth Factor-I in Growing Sheep Nourished by Total Intragastric Infusions
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 Title & Authors
Relationships between Methionine Supply, Nitrogen Retention and Plasma Insulin-like Growth Factor-I in Growing Sheep Nourished by Total Intragastric Infusions
Li, Chong; Zhao, Guangyong;
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Four 4-month old CharolaisDorset male sheep (initial liveweight ), fitted with rumen and abomasal fistulas and nourished by total intragastric infusions, were used to study the relationships between methionine (Met) supply, nitrogen (N) retention and plasma insulin-like growth factor-I (IGF-I). Four graded levels of Met, i.e. 0 g/16 g N, 1.76 g/16 g N, 3.52 g/16 g N and 7.04 g/16 g N, were infused into abomasums as experimental treatments. The sheep and treatments were allocated in a incomplete Latin square design (Yudon square design). The experiment lasted 3 periods and each period was 10 days. Quadratic correlations were found between Met level (x, g/16 g N) and N retention (y, g/d): y = +0.41x+2.62, = 0.66, n = 12, p = 0.008, and between methionine level (x, g/16 g N) and plasma IGF-I concentration (y, ng/ml): y = -4.53x+190.24, = 0.51, n = 12, p = 0.009. No significant correlation was found between plasma IGF-I (x, ng/ml) and N retention (y, g/d) (p>0.05). It was concluded that Met level had a significant influence on N retention and plasma IGF-I concentration whereas IGF-I might not be an important mediator in the regulation of N metabolism by Met in growing sheep nourished by total intragastric infusions.
Methionine;Nitrogen Retention;IGF-I;Sheep;
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Berthiaume, R., P. Dubreuil, M. Stevenson, B. W. McBride and H. Lapierre. 2001. Intestinal disappearance and mesenteric and portal appearance of amino acids in dairy cows fed ruminally protected methionine. J. Dairy Sci. 84:194-203. crossref(new window)

Cho, J., T. R. Overton, C. G. Schwab and L. W. Tauer. 2007. Determining the amount of rumen-protected methionine supplement that corresponds to the optimal levels of methionine in metabolizable protein for maximizing milk protein production and profit on dairy farms. J. Dairy Sci. 90:4908-4916. crossref(new window)

Fernandez-Figares, I., M. Lachica, R. Nieto, M. G. Rivera-Ferre and J. F. Aguilera. 2007. Serum profile of metabolites and hormones in obese (Iberian) and lean (Landrace) growing gilts fed balanced or lysine deficient diets. Livest. Sci. 110:73-81. crossref(new window)

Fraser, D. L., E. R. Orskov, F. G. Whitelaw and M. F. Franklin. 1991. Limiting amino acids in dairy cows given casein as the sole source of protein. Livest. Prod. Sci. 28:235-252. crossref(new window)

Goulas, C., G. Zervas and G. Papadopoulos. 2003. Effect of dietary animal fat and methionine on dairy ewes milk yield and milk composition. Anim. Feed Sci. Technol. 105:43-35. crossref(new window)

Lee, H. G., Y. J. Choi, S. R. Lee, H. Kuwayama, H. Hidari and S. K. You. 2005. Effects of dietary protein and growth hormone-releasing peptide (GHRP-2) on plasma IGF-1 and IGFBPs in Holstein steers. Domest. Anim. Endocrinol. 28:134-146. crossref(new window)

Lynch, G. P., T. H. Elsasser, C. Jackson, T. S. Rumsey and M. J. Camp. 1991. Nitrogen metabolism of lactating ewes fed rumen-protected methionine and lysine. J. Dairy Sci. 74:2268-2276. crossref(new window)

MacLeod, N. A., W. Corrigall, R. A. Stirton and E. R. Orskov. 1982. Intragastric infusion of nutrients in cattle. Br. J. Nutr. 47:547-549. crossref(new window)

Miller, R. A., G. Buehner, Y. Y. Chang, J. M. Harper, R. Sigler and M. Smith-Wheelock. 2005. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4:119-125. crossref(new window)

Misciattelli, L., V. F. Kristensen, M. Vestergaard, M. R. Weisbjerg, K. Sejrsen and T. Hvelplund. 2003. Milk production, nutrient utilization, and endocrine responses to increased postruminal lysine and methionine supply in dairy cows. J. Dairy Sci. 86:275-286. crossref(new window)

Oliver, M. H., J. E. Harding, B. H. Breier, P. C. Evans and P. D. Gluckman. 1993. Glucose but not a mixed amino acid infusion regulates plasma insulin-like growth factor-I concentrations in fetal sheep. Pediatr. Res. 34:62-65. crossref(new window)

Pell, J. M., J. C. Saunders and R. S. Gilmour. 1993. Differential regulation of transcription initiation from insulin-like growth factor-I (IGF-I) leader exons and of tissue IGF-I expression in response to changed growth hormone and nutritional status in sheep. Endocrinology 132:1797-1807. crossref(new window)

Preynat, A., H. Lapierre, M. C. Thivierge, M. F. Palin, J. J. Matte, A. Desrochers and C. L. Girard. 2009. Effects of supplements of folic acid, vitamin B12, and rumen-protected methionine on whole body metabolism of methionine and glucose in lactating dairy cows. J. Dairy Sci. 92:677-689. crossref(new window)

Ren, J. B., G. Y. Zhao, Y. X. Li and Q. X. Meng. 2007. Influence of dietary lysine level on whole-body protein turnover, plasma IGF-I, GH and insulin concentration in growing pigs. Livest. Sci. 110:126-132. crossref(new window)

Roy, H. and H. Lapierre. 2000. Whole-body protein metabolism and plasma profiles of amino acids and hormones in growing barrows fed diets adequate or deficient in lysine. Can. J. Anim. Sci. 18:293-308.

Schelling, G. T., J. E. Chandler and G. C. Scott. 1973. Postruminal supplemental methionine infusion to sheep fed high quality diets. J. Anim. Sci. 37:1034-1039.

Stubbs, A. K., N. M. Wheelhouse, M. A. Lomax and D. G. Hazlerigg. 2002. Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. J. Endocrinol. 174:335-341. crossref(new window)

Sun, Y. B. and G. Y. Zhao. 2009. The relationship between the volatile fatty acids supply and the nitrogen retention in growing sheep nourished by total intragastric infusions. Small Rumin. Res. 81:8-12. crossref(new window)

Sun, Z. H., Z. L. Tan, M. S. Liu, G. O. Tayo, B. Lin, B. Teng, S. X. Tang, J. M. Wang, Y. P. Liao, Y. F. Pan, J. R. Wang, X. G. Zhao and Y. Hu. 2007. Effects of dietary methionine and lysine sources on nutrient digestion, nitrogen utilization, and duodenal amino acid flow in growing goats. J. Anim. Sci. 85:3340-3347. crossref(new window)

Zhao, G. Y., M. Duric, N. A. MacLeod, E. R. Orskov, F. D. DeB Hovell and Y. L. Feng. 1995. The use of intragastric nutrition to study saliva secretion and the relationship between rumen osmotic pressure and water transport. Br. J. Nutr. 73:155-161. crossref(new window)

Zakin, M. M., E. Poskus, A. C. Paladini, J. M. Dellacha and J. A. Santom. 1975. Influence of some chemical treatments on the immunological properties of various mammalian growth hormones. Immunochemistry 12:125-129. crossref(new window)