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Immunophenotype Characterization for Swine Selected Line, Which is Resistant for the Mycoplasma Pneumonia
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 Title & Authors
Immunophenotype Characterization for Swine Selected Line, Which is Resistant for the Mycoplasma Pneumonia
Katayama, Masafumi; Fukuda, Tomokazu; Okamuara, Toshihiro; Suda, Yoshihito; Suzuki, Eisaku; Uenishi, Hirohide; Suzuki, Keiichi;
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 Abstract
Mycoplasma Pneumonia of swine (MPS) decreases the daily growth of pigs, and, co-infection with a virus sometimes causes severe pneumonia. Genetic selection of pigs resistant to the pulmonary MPS lesion might solve the economic loss due to MPS in animal production. Here, we examined the immunophenotype of Landrace line (Miyagino L2), genetically selected to reduce the incidence of pulmonary MPS lesion for 5 generations in Miyagi Prefecture Animal Industry Experiment Station. Although this line is expected to be resistant to the pulmonary MPS lesion, the biological characteristics of its immune function are not clear. We investigated details of the immunorelated phenotype of Miyagino L2 at the hematological and molecular biological level, including cytokine expression, and compared the results with that of non-genetically selected Landrace. Miyagino L2 showed decreased antigen-specific IgG and IgM production and increased CD8-positive T-cell population, and high levels of cortisol concentration, suggesting that the MPS-resistant phenotype is associated these immunological differences. Additionally, T-cell CD4 expression was highly correlated with the MPS expected breeding value. Although the detailed mechanisms underlying this high correlation remain unknown, our result suggested that the genetic selection of the expression level of CD4 might be useful to improve MPS resistance in pig production.
 Keywords
MPS Lesion;Immunoglobulin;T Cell;Biomarker;Porcine;CD4 and CD8;
 Language
English
 Cited by
1.
Selection for resistance to swine mycoplasmal pneumonia over 5 generations in Landrace pigs, Livestock Science, 2012, 147, 1-3, 20  crossref(new windwow)
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Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in the Landrace line influences the expression of soluble factors in blood after MPS vaccine sensitization, Animal Science Journal, 2014, 85, 4, 365  crossref(new windwow)
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Immunological characterization of peripheral blood leukocytes using vaccine for mycoplasmal pneumonia of swine (MPS) in swine line selected for resistance to MPS, Animal Science Journal, 2013, n/a  crossref(new windwow)
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Effects of mycoplasmal pneumonia of swine (MPS) lung lesion-selected Landrace pigs on MPS resistance and immune competence in three-way crossbred pigs, Animal Science Journal, 2016  crossref(new windwow)
9.
Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia, Comparative Immunology, Microbiology and Infectious Diseases, 2016, 48, 33  crossref(new windwow)
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