JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Changes of Hypothalamic GnRH-I, POMC and NPY mRNA Expression and Serum IGF-I and Leptin Concentrations during Maturation of Shaoxing Ducks (Anas platyrhynchos)
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Changes of Hypothalamic GnRH-I, POMC and NPY mRNA Expression and Serum IGF-I and Leptin Concentrations during Maturation of Shaoxing Ducks (Anas platyrhynchos)
Ni, Y.; Lu, L.; Chen, J.; Zhao, Ruqian;
  PDF(new window)
 Abstract
Sexual maturity in poultry is controlled by a complex neural circuit located in the basal forebrain, which integrates the central and peripheral signals to activate hypothalamic gonadotrophin-releasing hormone (GnRH) secretion. This study demonstrated the changes of GnRH-I, POMC and NPY mRNA transcription in hypothalamus and IGF-I and leptin levels in serum of Shaoxing ducks during puberty. Body weight increased progressively from d30 to d120 and at d120 the flock reached 5% of laying rate. A significant upregulation of hypothalamic GnRH-I mRNA expression was observed from d60, reaching the peak at d120. POMC and NPY mRNA expression in hypothalamus showed a similar pattern, which increased from d30 to d60, followed by a significant decrease towards sexual maturity. Serum IGF-I levels exhibited two peaks at d30 and d120, respectively. Serum leptin displayed a single peak at d90. The results indicate that the down-regulation of POMC and NPY genes in hypothalamus coincides with the up-regulation of GnRH-I gene to initiate sexual maturation in ducks. In addition, peripheral IGF-I and leptin may relay the peripheral metabolic status to the central system and contribute to the initiation of the reproductive function in ducks.
 Keywords
GnRH-I;POMC;NPY;Leptin;IGF-1;Sexual Maturity;Duck;
 Language
English
 Cited by
1.
Patterns of folliculogenesis in ducks following the administration of a gonadotropin-releasing hormone 1 (GnRH) analogue, Journal of Genetic Engineering and Biotechnology, 2012, 10, 1, 93  crossref(new windwow)
2.
Steroid hormones, stress and the adolescent brain: A comparative perspective, Neuroscience, 2013, 249, 115  crossref(new windwow)
 References
1.
Barash, I. A., C. C. Cheung, D. S. Weigle, H. Ren, E. B. Kabigting, J. L. Kuijper, D. K. Clifton and R. A. Steiner. 1996. Leptin is a metabolic signal to the reproductive system. Endocrinology 137:3144-3147. crossref(new window)

2.
Barb, C. R., G. J. Hausman and K. Czaja. 2005. Leptin: a metabolic signal affecting central regulation of reproduction in the pig. Domest. Anim. Endocrinol. 29:186-192. crossref(new window)

3.
Blomqvist, A. G., C. Soderberg, I. Lundell, R. J. Milner and D. Larhammar. 1992. Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones. Proc. Natl. Acad. Sci. USA. 89:2350-2354. crossref(new window)

4.
Chehab, F. F., K. Mounzih, R. Lu and M. E. Lim. 1997. Early onset of reproductive function in normal female mice treated with leptin. Science 275:88-90. crossref(new window)

5.
Daftary, S. S. and A. C. Gore. 2003. Developmental changes in hypothalamic insulin-like growth factor-1: relationship to gonadotropin-releasing hormone neurons. Endocrinology 144:2034-2045. crossref(new window)

6.
Daftary, S. S. and A. C. Gore. 2005. IGF-1 in the brain as a regulator of reproductive neuroendocrine function. Exp. Biol. Med. 230:292-306.

7.
Ebling, F. J. 2005. The neuroendocrine timing of puberty. Reproduction 129:675-683. crossref(new window)

8.
El, M. M., A. Sahu, S. Ramaswamy and T. M. Plant. 2000. Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates. Proc. Natl. Acad. Sci. USA. 97:6179-6184. crossref(new window)

9.
Fraley, G. S. and W. J. Kuenzel. 1993. Precocious puberty in chicks (Gallus domesticus) induced by central injections of neuropeptide Y. Life. Sci. 52:1649-1656. crossref(new window)

10.
Genazzani, A. R., F. Bernardi, P. Monteleone, S. Luisi and M. Luisi. 2000. Neuropeptides, neurotransmitters, neurosteroids, and the onset of puberty. Ann. N.Y. Acad. Sci. 900:1-9.

11.
Gruenewald, D. A. and A. M. Matsumoto. 1991. Age-related decrease in proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain. Neurobiol. Aging 12:113-121. crossref(new window)

12.
Hu, Y., Y. D. Ni, L. Z. Ren, J. Dai and R. Q. Zhao. 2008. Leptin is involved in the effects of cysteamine on egg laying of hens, characteristics of eggs, and posthatch growth of broiler offspring. Poult. Sci. 87(9):1810-1817. crossref(new window)

13.
Kalra, P. S. and S. P. Kalra. 1986. Steroidal modulation of the regulatory neuropeptides: luteinizing hormone releasing hormone, neuropeptide Y and endogenous opioid peptides. J. Steroid Biochem. 25:733-740. crossref(new window)

14.
Knight, P. G. 1983. Variations in hypothalamic luteinizing hormone releasing hormone content and release in vitro and plasma concentrations of luteinizing hormone and testosterone in developing cockerels. J. Endocrinol. 99:311-319. crossref(new window)

15.
Knight, P. G. and R. T. Gladwell and F. J. Cunningham. 1985. Release of LHRH in vitro and anterior pituitary responsiveness to LHRH in vivo during sexual maturation in pullets (Gallus domesticus). J. Reprod. Fertil. 74:145-151. crossref(new window)

16.
Knight, P. G., S. C. Stansfield and F. J. Cunningham. 1990. Attenuation by an opioid agonist of the oestradiol-induced LH surge in anoestrous ewes and its reversal by naloxone. Domest. Anim. Endocrinol. 7:165-172. crossref(new window)

17.
Minami, S., S. A. Frautschy, P. M. Plotsky, S. W. Sutton and D. K. Sarkar. 1990. Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizinghormone- releasing hormone. Neuroendocrinology 52:112-115. crossref(new window)

18.
Prasad, B. M., C. D. Conover, D. K. Sarkar, J. Rabii and J. P. Advis. 1993. Feed restriction in prepubertal lambs: effect on puberty onset and on in vivo release of luteinizing-hormonereleasing hormone, neuropeptide Y and beta-endorphin from the posterior-lateral median eminence. Neuroendocrinology 57:1171-1181. crossref(new window)

19.
Sharp, P. J., R. T. Talbot, G. M. Main, I. C. Dunn, H. M. Fraser and N. S. Huskisson. 1990. Physiological roles of chicken LHRH-I and -II in the control of gonadotrophin release in the domestic chicken. J. Endocrinol. 124:291-299. crossref(new window)

20.
Stansfield, S. C. and F. J. Cunningham. 1987. Modulation by endogenous opioid peptides of the secretion of LHRH from cockerel (Gallus domesticus) mediobasal hypothalamic tissue. J. Endocrinol. 114:103-110. crossref(new window)

21.
Stevenson, T. J., and S. A. dougall-Shackleton. 2005. Season- and age-related variation in neural cGnRH-I and cGnRH-II immunoreactivity in house sparrows (Passer domesticus). Gen. Comp. Endocrinol. 143:33-39. crossref(new window)