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A Genome-wide Scan for Selective Sweeps in Racing Horses
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 Title & Authors
A Genome-wide Scan for Selective Sweeps in Racing Horses
Moon, Sunjin; Lee, Jin Woo; Shin, Donghyun; Shin, Kwang-Yun; Kim, Jun; Choi, Ik-Young; Kim, Jaemin; Kim, Heebal;
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 Abstract
Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic consequence of putative candidate loci by candidate gene association mapping for the finishing time in 240 Thoroughbred horses. We found a significant association with the trait for Ral GApase alpha 2 (RALGAP2) that regulates a variety of cellular processes of signal trafficking. Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2) genes have similar roles in signal trafficking, suggesting that a co-evolving gene cluster located on the chromosome 22 is under strong artificial selection in racehorses.
 Keywords
Single Nucleotide Polymorphism;Racehorse;Selective Sweep;Quantitative Trait Loci;
 Language
English
 Cited by
1.
Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep, Animal Genetics, 2016  crossref(new windwow)
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