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1H-Nuclear Magnetic Resonance-Based Plasma Metabolic Profiling of Dairy Cows with Fatty Liver
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 Title & Authors
1H-Nuclear Magnetic Resonance-Based Plasma Metabolic Profiling of Dairy Cows with Fatty Liver
Xu, Chuang; Sun, Ling-wei; Xia, Cheng; Zhang, Hong-you; Zheng, Jia-san; Wang, Jun-song;
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Fatty liver is a common metabolic disorder of dairy cows during the transition period. Historically, the diagnosis of fatty liver has involved liver biopsy, biochemical or histological examination of liver specimens, and ultrasonographic imaging of the liver. However, more convenient and noninvasive methods would be beneficial for the diagnosis of fatty liver in dairy cows. The plasma metabolic profiles of dairy cows with fatty liver and normal (control) cows were investigated to identify new biomarkers using nuclear magnetic resonance. Compared with the control group, the primary differences in the fatty liver group included increases in -hydroxybutyric acid, acetone, glycine, valine, trimethylamine-N-oxide, citrulline, and isobutyrate, and decreases in alanine, asparagine, glucose, -aminobutyric acid glycerol, and creatinine. This analysis revealed a global profile of endogenous metabolites, which may present potential biomarkers for the diagnosis of fatty liver in dairy cows.
Dairy Cow;Fatty Liver;-Nuclear Magnetic Resonance;Metabolomics;Plasma;
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Crenn, P., K. Vahedi, A. Lavergne-Slove, L. Cynober, C. Matuchansky, and B. Messing. 2003. Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 124:1210-1219. crossref(new window)

Dieterle F., A. Ross, G. Schlotterbeck, and H. Senn. 2006. Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics. Anal. Chem. 78: 4281-4290. crossref(new window)

Du Y., Q. Meng, Q. Zhang, and F. Guo. 2012. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT. Amino Acids 43:725-734. crossref(new window)

Faghfoury H., J. Baruteau, H. O. de Baulny, J. Haberle, and A. Schulze. 2011. Transient fulminant liver failure as an initial presentation in citrullinemia type I. Mol. Genet. Metab. 102: 413-417. crossref(new window)

Gena, P., M. Mastrodonato, P. Portincasa, E. Fanelli, D. Mentino, A. Rodriguez, R. A. Marinelli, C. Brenner, G. Fruhbeck, M. Svelto, and G. Calamita. 2013. Liver glycerol permeability and aquaporin-9 are dysregulated in a murine model of nonalcoholic fatty liver disease. PLoS One. 8:e78139. crossref(new window)

Gonzalez, F. D., R. Muino, V. Pereira, R. Campos, and J. L. Benedito. 2011. Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows. J. Vet .Sci. 12:251-255. crossref(new window)

Haque, M. N., H. Rulquin, and S. Lemosquet. 2013. Milk protein responses in dairy cows to changes in postruminal supplies of arginine, isoleucine, and valine. J. Dairy Sci. 96:420-430. crossref(new window)

Harita, N., T. Hayashi, K. K. Sato, Y. Nakamura, T. Yoneda, G. Endo, and H. Kambe. 2009. Lower serum creatinine is a new risk factor of type 2 diabetes: the Kansai healthcare study. Diabetes Care 32:424-426. crossref(new window)

Herdt, T. H., L. Goeders, J. S. Liesman, and R. S. Emery. 1983. Test for estimation of bovine hepatic lipid content. J. Am. Vet. Med. Assoc. 182:953-955.

Laffel, L. 1999. Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab. Res. Rev. 15: 412-426. crossref(new window)

Jorritsma R., H. Jorritsma, Y. H. Schukken, and G. H. Wentink. 2000. Relationships between fatty liver and fertility and some periparturient diseases in commercial Dutch dairy herds. Theriogenology 54:1065-1074. crossref(new window)

Hayirli, A., R. R. Grummer, E. V. Nordheim, and P. M. Crump. 2002. Animal and dietary factors affecting feed intake during the prefresh transition period in Holsteins. J. Dairy Sci. 85:3430-3443. crossref(new window)

Koeth, R. A., Z. Wang, B. S. Levison, J. A. Buffa, E. Org, B. T. Sheehy, E. B. Britt, X. Fu, Y. Wu, L. Li, J. D. Smith, J. A. DiDonato, J. Chen, H. Li, G. D. Wu, J. D. Lewis, M. Warrier, J. M. Brown, R. M. Krauss, W. H. Tang, F. D. Bushman, A. J. Lusis, and S. L. Hazen. 2013. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 19:576-585. crossref(new window)

Moyes, K. M., E. Bendixen, M. C. Codrea, and K. L. Ingvartsen. 2013. Identification of hepatic biomarkers for physiological imbalance of dairy cows in early and mid lactation using proteomic technology. J. Dairy Sci. 96:3599-3610. crossref(new window)

Mukherjee, S., S. K. Das, K. Vaidyanathan, and D. M. Vasudevan. 2008. Consequences of alcohol consumption on neurotransmitters -An overview. Curr. Neurovascular Res. 5:266-272. crossref(new window)

Mukherjee, S., K. Vaidyanathan, D. M. Vasudevan, and S. K. Das. 2010. Role of plasma amino acids and gaba in alcoholic and non-alcoholic fatty liver disease-a pilot study. Indian J. Clin. Biochem. 25:37-42. crossref(new window)

Ning, M., L. M. Lowenstein, and C. S. Davidson. 1967. Serum amino acid concentrations in alcoholic hepatitis. J. Lab. Clin. Med. 70:554-562.

Oikawa, S., Y. Mizunuma, Y. Iwasaki, and M. Tharwat. 2010. Changes of very low-density lipoprotein concentration in hepatic blood from cows with fasting-induced hepatic lipidosis. Can. J. Vet. Res. 74:317-320.

Patterson, M. C. 2005. Metabolic mimics: The disorders of Nlinked glycosylation. Semin. Pediatr. Neurol. 12:144-151. crossref(new window)

Sejersen, H., M. T. Sorensen, T. Larsen, E. Bendixen, and K. L. Ingvartsen. 2012. Liver protein expression in dairy cows with high liver triglycerides in early lactation. J. Dairy Sci. 95: 2409-2421. crossref(new window)

Shemesh, O., H. Golbetz, J. P. Kriss, and B. D. Myers. 1985. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int. 28:830-838. crossref(new window)

Smith, T. R., A. R. Hippen, D. C. Beitz, and J. W. Young. 1997. Metabolic characteristics of induced ketosis in normal and obese dairy cows. J. Dairy Sci. 80:1569-1581. crossref(new window)

Song, X. F., J. S. Wang, P. R. Wang, N. Tian, M. H. Yang, and L. Y. Kong. 2013. 1H NMR-based metabolomics approach to evaluate the effect of Xue-Fu-Zhu-Yu decoction on hyperlipidemia rats induced by high-fat diet. J. Pharm. Biomed. Anal. 78:202-210.

Sun, L. W., H. Y. Zhang, L. Wu, S. Shu, C. Xia, C. Xu, and J. S. Zheng. 2014. 1H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis. J. Dairy Sci. 97:1552-1562. crossref(new window)

Takahashi, Y., S. Koyama, H. Tanaka, S. Arawaka, M. Wada, T. Kawanami, H. Haga, H. Watanabe, K. Toyota, C. Numakura, K. Hayasaka, and T. Kato. 2012. An elderly Japanese patient with adult-onset type II citrullinemia with a novel D493G mutation in the SLC25A13 gene. Intern. Med. 51:2131-2134. crossref(new window)

Wildman, E. E., G. M. Jones, P. E. Wagner, R. L. Boman, H. F. Troutt Jr, and T. N. Lesch. 1982. A dairy cow body condition scoring system and its relationship to selected production characteristics. J. Dairy Sci. 65:495-501. crossref(new window)

Wu, G., B. Imhoff-Kunsch, and A. W. Girard. 2012. Biological mechanisms for nutritional regulation of maternal health and fetal development. Paediatr. Perinat. Epidemiol. 26:4-26. crossref(new window)

Xu, C., Z. Wang, G. W. Liu, X. B. Li, G. H. Xie, C. Xia, and H. Y. Zhang. 2008. Metabolic characteristic of the liver of dairy cows during ketosis based on comparative proteomics. Asian Australas. J. Anim. Sci. 21:1003-1010. crossref(new window)

Zhang, H. Y., L. Wu, C. Xu, C. Xia, L. W. Sun, and S. Shu. 2013. Plasma metabolomic profiling of dairy cows affected with ketosis using gas chromatography/mass spectrometry. BMC Vet. Res. 9:186. crossref(new window)

Zhao, X. J., C. Huang, H. Lei, X. Nie, H. Tang, and Y. Wang. 2011. Dynamic metabolic response of mice to acute mequindox exposure. J. Proteome Res. 10:5183-5190. crossref(new window)