Advanced SearchSearch Tips
Effects of Graded Levels of Isomaltooligosaccharides on the Performance, Immune Function and Intestinal Status of Weaned Pigs
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effects of Graded Levels of Isomaltooligosaccharides on the Performance, Immune Function and Intestinal Status of Weaned Pigs
Wang, X.X.; Song, P.X.; Wu, H.; Xue, J.X.; Zhong, X.; Zhang, L.Y.;
  PDF(new window)
The objective of this study was to investigate the effects of graded levels of isomaltooligosaccharides (IMO) on the performance, immune function and intestinal microflora and intestinal mucosal morphology of weaned pigs. In a 28-day experiment, one hundred eighty, twenty eight-day-old, crossbred (DurocLarge WhiteLandrace), weaned pigs, with an initial body weight of , were fed either an unsupplemented corn-soybean meal based diet or similar diets supplemented with 0.2%, 0.4%, 0.6%, or 0.8% IMO added at the expense of corn. Each treatment was replicated six times with six pigs (three barrows and three gilts) per pen. From day 0 to 14, weight gain was linearly increased (p<0.05), while gain:feed (p<0.05) was linearly improved and diarrhea rate (p
Immune Function;Intestinal Ststus;Isomaltooligosaccharides;Performance;Weaned Pigs;
 Cited by
Effects of graded levels of cupric citrate on growth performance, antioxidant status, serum lipid metabolites and immunity, and tissue residues of trace elements in weaned pigs, Asian-Australasian Journal of Animal Sciences, 2016, 30, 4, 538  crossref(new windwow)
Al-Banna, N. A., D. Pavlovic, M. Grundling, J. Zhou, M. Kelly, S. Whynot, O. Hung, B. Johnston, T. B. Issekutz, H. Kern, V. Cerny, and Ch. Lehmann. 2013. Impact of antibiotics on the microcirculation in local and systemic inflammation. Clin. Hemorheol. Microcirc. 53:155-169.

AOAC. 2000. Official Methods of Analysis. 17th edn. Association of Official Analytical Chemists, Gaithersburg, MD, USA.

Brocker, C., D. Thompson, A. Matsumoto, D. W. Nebert, and V. Vasiliou. 2010. Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum. Genomics 5:30-55. crossref(new window)

Chen, H. L., Y. H. Lu, J. J. Lin, and L. Y. Ko. 2001. Effects of isomalto-oligosaccharides on bowel functions and indicators of nutritional status in constipated elderly men. J. Am. Coll. Nutr. 20:44-49. crossref(new window)

Delzenne, N. M. 2003. Oligosaccharides: state of the art. Proc. Nutr. Soc. 62:177-182. crossref(new window)

Goffin, D., N. Delzenne, C. Blecker, E. Hanon, C. Deroanne, and M. Paquot. 2001. Will isomalto-oligosaccharides, a wellestablished functional food in Asia, break through the European and American market? The status of knowledge on these prebiotics. Crit. Rev. Food Sci. Nutr. 51:394-409.

Hayashi, S., T. Hinotani, Y. Takasaki, and K. Imada. 1994. The enzymatic reaction for the production of panose and isomaltose by glucosyltransferase from Aureobasidium. Lett. Appl. Microbiol. 19:247-248. crossref(new window)

Kaneko, T., T. Matsukubo, T. Yatake, Y. Muramatsu, and Y. Takaesu. 1995a. Evaluation of acidogenicity of commercial isomaltooligosaccharides mixture and its hydrogenated derivative by measurement of pH response under human dental plaque. Biosci. Biotechnol. Biochem. 59:372-377. crossref(new window)

Kaneko, T., A. Yokoyama, and M. Suzuki. 1995b. Digestibility characteristics of isomaltooligosaccharides in comparison with several saccharides using the rat jejunum loop method. Biosci. Biotechnol. Biochem. 59:1190-1194. crossref(new window)

Ketabi, A., L. A. Dieleman, and M. G. Ganzle. 2011. Influence of isomalto-oligosaccharides on intestinal microbiota in rats. J. Appl. Microbiol. 110:1297-1306. crossref(new window)

Kik, M. J., J. Huisman, A. F. van der Poel, and J. M. Mouwen. 1990. Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolus vulgaris beans. Vet. Pathol. 27:329-334. crossref(new window)

Kohmoto, T., K. Tsuji, T. Kaneko, M. Shiota, F. Fukui, H. Takaku, Y. Nakagawa, T. Ichikawa, and S. Kobayash. 1992. Metabolism of 13C-Isomaltooligosaccharides in healthy men. Biosci. Biotechnol. Biochem. 56:937-940. crossref(new window)

Li, J., B. Tan, and K. Mai. 2009a. Dietary probiotic Bacillus OJ and isomaltooligosaccharides influence the intestine microbial populations, immune responses and resistance to white spot syndrome virus in shrimp (Litopenaeus vannamei). Aquaculture 291:35-40. crossref(new window)

Li, Y. J., G. Y. Zhao, W. Du, and T. J. Zhang. 2009b. Effect of dietary isomaltooligosaccharides on nutrient digestibility and concentration of glucose, insulin, cholesterol and triglycerides in serum of growing pigs. Anim. Feed Sci. Technol. 151:312- 315. crossref(new window)

Li, M., W. L. Liu, G. Y. Zhao, L. M. Yu, Y. H. Wu, Y. F. Wu, Z. Q. Pan, and Z. H. Shen. 2010. Effect of different oligosaccharides on immunity and production performance of piglets. Anim. Husb. Feed Sci. Z2:9-11.

Litman, G. W., J. P. Rast, M. J. Shamblott, R. N. Haire, M. Hulst, W. Roess, R. T. Litman, K. R. Hinds-Frey, A. Zilch, and C. T. Amemiya. 1993. Phylogenetic diversification of immunoglobulin genes and the antibody repertoire. Mol. Biol. Evol. 10:60-72.

Marquardt, R. R., L. Z. Jin, J. W. Kim, L. Fang, A. A. Frohlich, and S. K. Baidoo. 1999. Passive protective effect of egg-yolk antibodies against enterotoxigenic Escherichia coli K88+ infection in neonatal and early-weaned piglets. FEMS Immunol. Med. Microbiol. 23:283-288. crossref(new window)

Mizubuchi, H., T. Yajima, N. Aoi, T. Tomita, and Y. Yoshikai. 2005. Isomalto-oligosaccharides polarize Th1-like responses in intestinal and systemic immunity in mice. J. Nutr. 135:2857- 2861. crossref(new window)

National Research Council. 1998. Nutrient Requirements of Swine. 10th Ed. National Academy Press, Washington, DC, USA.

Rehman, H., W. Vahjen, A. Kohl-Parisini, A. Ijaz, and J. Zentek. 2009. Influence of fermentable carbohydrates on the intestinal bacteria and enteropathogens in broilers. Worlds Poult. Sci. J. 65:75-90. crossref(new window)

Sung, H. Y., H. J. Jeong, and Y. S. Choi. 2004. Effects of fructans and isomaltooligosaccharide on large bowel mass and plasma and fecal immunoglobulin A in rat. Nutr. Sci. 7:196-200.

Thiex, N. J., H. Manson, S. Andersson, and J. A. Persson. 2002. Determination of crude protein in animal feed, forage, grain, and oilseeds by using block digestion with a copper catalyst and steam distillation into boric acid: collaborative study. J. AOAC Int. 85:309-317.

Thitaram, S. N., C. H. Chung, D. F. Day, A. Hinton Jr, J. S. Bailey, and G. R. Siragusa. 2005. Isomaltooligosaccharide increases cecal Bifidobacterium population in young broiler chickens. Poult. Sci. 84:998-1003. crossref(new window)

Vetere, A., A. Gamini, C. Campa, and S. Paoletti. 2000. Regiospecific transglycolytic synthesis and structural characterization of 6-O-alpha-glucopyranosyl-glucopyranose (isomaltose). Biochem. Biophys. Res. Commun. 274:99-104. crossref(new window)

Wang, H. F., P. S. Lim, M. D. Kao, E. C. Chan, L. C. Lin, and N. P. Wang. 2001. Use of isomalto-oligosaccharide in the treatment of lipid profiles and constipation in hemodialysis patients. J. Ren. Nutr. 11:73-79. crossref(new window)

Wang, S., H. Zhu, C. Lu, Z. Kang, Y. Luo, L. Feng, and X. Lu. 2012. Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals. J. Dairy Sci. 95:4813-4822. crossref(new window)

Watanabe, T., M. Watanabe, and K. Seiji. 2002. Prophylactic or ameliorating agent for immunological dysfunction, prophylactic or ameliorating agent for microbism, tumor immunological enhancer and prophylactic or ameliorating agent for in vivo various dysfunctions and functional food comprising alpha-1,6-bonded chain glucose oligomer as active ingredient. Japanese Patent, JP 2002161039.

Yen, C. H., Y. H. Tseng, Y. W. Kuo, M. C. Lee, and H. L. Chen. 2011. Long-term supplementation of isomaltooligosaccharides improved colonic microflora profile, bowel function, and blood cholesterol levels in constipated elderly people: a placebo-controlled, diet-controlled trial. Nutrition 27:445-450. crossref(new window)

Zhang, W. F., D. F. Li, W. Q. Lu, and G. F. Yi. 2003. Effects of isomalto-oligosaccharides on broiler performance and intestinal microflora. Poult. Sci. 82:657-663. crossref(new window)

Zhang, Q., B. Tan, K. Mai, W. Zhang, H. Ma, Q. Ai, X. Wang, and Z. Liufu. 2011. Dietary administration of Bacillus (B. licheniformis and B. subtilis) and isomaltooligosaccharide influences the intestinal microflora, immunological parameters and resistance against Vibrio alginolyticus in shrimp, Penaeus japonicus (Decapoda: Penaeidae). Aquac. Res. 42:943-952. crossref(new window)

Zhao, X., L. Li, Q. Luo, M. Ye, G. Luo, and Z. Kuang. 2015. Effects of mulberry (Morus alba L.) leaf polysaccharides on growth performance, diarrhea, blood parameters, and gut microbiota of early-weanling pigs. Livest. Sci. 177:88-94. crossref(new window)