Advanced SearchSearch Tips
Identification of Molecular Signatures from Different Vaccine Adjuvants in Chicken by Integrative Analysis of Microarray Data
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Identification of Molecular Signatures from Different Vaccine Adjuvants in Chicken by Integrative Analysis of Microarray Data
Kim, Duk Kyung; Won, Kyeong Hye; Moon, Seung Hyun; Lee, Hak-Kyo;
  PDF(new window)
The present study compared the differential functions of two groups of adjuvants, Montanide incomplete Seppic adjuvant (ISA) series and Quil A, cholesterol, dimethyl dioctadecyl ammonium bromide, and Carbopol (QCDC) formulations, in chicken by analyzing published microarray data associated with each type of vaccine adjuvants. In the biological function analysis for differentially expressed genes altered by two different adjuvant groups, ISA series and QCDC formulations showed differential effects when chickens were immunized with a recombinant immunogenic protein of Eimeria. Among the biological functions, six categories were modified in both adjuvant types. However, with respect to "Response to stimulus", no biological process was modified by the two adjuvant groups at the same time. The QCDC adjuvants showed effects on the biological processes (BPs) including the innate immune response and the immune response to the external stimulus such as toxin and bacterium, while the ISA adjuvants modified the BPs to regulate cell movement and the response to stress. In pathway analysis, ISA adjuvants altered the genes involved in the functions related with cell junctions and the elimination of exogenous and endogenous macromolecules. The analysis in the present study could contribute to the development of precise adjuvants based on molecular signatures related with their immunological functions.
Vaccine Adjuvant;Chicken;Reanalysis;Microarray;
 Cited by
Anderson, A. J. 1970. Lysosomal enzyme activity in rats with adjuvant-induced arthritis. Ann. Rheum. Dis. 29:307-13. crossref(new window)

Aucouturier, J., S. Ascarateil, and L. Dupuis. 2006. The use of oil adjuvants in therapeutic vaccines. Vaccine 24 (Suppl 2):S44-S45. crossref(new window)

Baldridge, J. R. and J. R. Ward. 1997. Effective adjuvants for the induction of antigen-specific delayed-type hypersensitivity. Vaccine 15:395-401. crossref(new window)

Bowersock, T. L. and S. Martin. 1999. Vaccine delivery to animals. Adv. Drug Deliv. Rev. 38:167-194. crossref(new window)

Cox, J. C. and A. R. Coulter. 1997. Adjuvants-A classification and review of their modes of action. Vaccine 15:248-256. crossref(new window)

Cox, S. J., N. Aggarwal, R. J. Statham, and P. V. Barnett. 2003. Longevity of antibody and cytokine responses following vaccination with high potency emergency FMD vaccines. Vaccine 21:1336-1347. crossref(new window)

Crawford, J. M. and K. Watanabe. 1994. Cell adhesion molecules in inflammation and immunity: Relevance to periodontal diseases. Crit. Rev. Oral Biol. Med. 5:91-123. crossref(new window)

Davidsen, J., I. Rosenkrands, D. Christensen, A. Vangala, D. Kirby, Y. Perrie, E. M. Agger, and P. Andersen. 2005. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim. Biophys. Acta Biomembranes 1718:22-31. crossref(new window)

Dominowski, P. J., R. M. Mannan, R. L. Krebs, J. R. Thompson, T. A. Childers, M. K. Olsen, J. R. J. Yancey, R. Weeratna, S. Zhang, and C. M. Bagi. 2009. Novel adjuvant compositions. US 2009/0324641 A1. Pfizer Inc., New York, NY , USA.

Drane, D., C. Gittleson, J. Boyle, and E. Maraskovsky. 2007. ISCOMATRIX adjuvant for prophylactic and therapeutic vaccines. Expert Rev. Vaccines 6:761-772. crossref(new window)

Dupuis, L., S. Ascarateil, J. Aucouturier, and V. Ganne. 2006. SEPPIC vaccine adjuvants for poultry. Ann. NY Acad. Sci. 1081:202-205. crossref(new window)

Geetha, T. and P. Varalakshmi. 1999. Effect of lupeol and lupeol linoleate on lysosomal enzymes and collagen in adjuvant-induced arthritis in rats. Mol. Cell. Biochem. 201:83-87. crossref(new window)

Gupta, R. K. and G. R. Siber. 1995. Adjuvants for human vaccines-current status, problems and future prospects. Vaccine 13:1263-1276. crossref(new window)

Jang, S. I., D. K. Kim, H. S. Lillehoj, S. H. Lee, K. W. Lee, F. Bertrand, L. Dupuis, S. Deville, J. Ben Arous, and E. P. Lillehoj. 2013. Evaluation of Montanide ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis. PLoS One 8(4):e59786. crossref(new window)

Jang, S. I., H. S. Lillehoj, S. H. Lee, K. W. Lee, E. P. Lillehoj, F. Bertrand, L. Dupuis, and S. Deville. 2011. Mucosal immunity against Eimeria acervulina infection in broiler chickens following oral immunization with profilin in Montanide adjuvants. Exp. Parasitol. 129:36-41. crossref(new window)

Jang, S. I., H. S. Lillehoj, S. H. Lee, K. W. Lee, M. S. Park, G. R. Bauchan, E. P. Lillehoj, F. Bertrand, L. Dupuis, and S. Deville. 2010. Immunoenhancing effects of Montanide ISA oil-based adjuvants on recombinant coccidia antigen vaccination against Eimeria acervulina infection. Vet. Parasitol. 172:221-228. crossref(new window)

Johnston, B. A., H. Eisen, and D. Fry. 1991. An evaluation of several adjuvant emulsion regimens for the production of polyclonal antisera in rabbits. Lab. Anim. Sci. 41:15-21.

Kim, D. K., H. S. Lillehoj, S. H. Lee, P. Dominowski, R. J. Yancey, and E. P. Lillehoj. 2012. Effects of novel vaccine/adjuvant complexes on the protective immunity against Eimeria acervulina and transcriptome profiles. Avian Dis. 56:97-109. crossref(new window)

Kumar, V. L. and S. Roy. 2007. Calotropis procera latex extract affords protection against inflammation and oxidative stress in Freund's complete adjuvant-induced monoarthritis in rats. Mediators Inflamm. Article ID 47523.

Leclerc, C. 2003. New approaches in vaccine development. Comp. Immunol. Microbiol. Infect. Dis. 26:329-341. crossref(new window)

Lee, K. W., H. S. Lillehoj, S. H. Lee, S. I. Jang, G. D. Ritter, D. A. Bautista, and E. P. Lillehoj. 2011. Impact of fresh or used litter on the posthatch immune system of commercial broilers. Avian Dis. 55:539-544. crossref(new window)

Leenaars, P. P. A. M., C. F. M. Hendriksen, A. F. Angulo, M. A. Koedam, and E. Claassen. 1994. Evaluation of several adjuvants as alternatives to the use of Freund's adjuvant in rabbits. Vet. Immunol. Immunopathol. 40:225-241. crossref(new window)

Leenaars, P. P., C. F. Hendriksen, M. A. Koedam, I. Claassen, and E. Claassen. 1995. Comparison of adjuvants for immune potentiating properties and side effects in mice. Vet. Immunol. Immunopathol. 48:123-138. crossref(new window)

Leenaars, P. P., M. A. Koedam, P. W. Wester, V. Baumans, E. Claassen, and C. F. Hendriksen. 1998. Assessment of side effects induced by injection of different adjuvant/antigen combinations in rabbits and mice. Lab. Anim. 32:387-406. crossref(new window)

Lillehoj, E. P., C. H. Yun, and H. S. Lillehoj. 2000a. Vaccines against the avian enteropathogens Eimeria, Cryptosporidium, and Salmonella. Anim. Health Res. Rev. 1:47-65. crossref(new window)

Lillehoj, H. S., K. D. Choi, M. C. Jenkins, V. N. Vakharia, K. D. Song, J. Y. Han, and E. P. Lillehoj. 2000b. A recombinant Eimeria protein inducing interferon-gamma production: Comparison of different gene expression systems and immunization strategies for vaccination against coccidiosis. Avian Dis. 44:379-389. crossref(new window)

Newman, M. J. and M. F. Powell. 1995. Immunological and formulation design considerations for subunit vaccines. Pharm. Biotechnol. 6:1-42. crossref(new window)

Nigrovic, P. A. and D. M. Lee. 2005. Mast cells in inflammatory arthritis. Arthritis Res. Ther. 7:1-11. crossref(new window)

Reddy, G. K. and S. C. Dhar. 1988. Studies on carbohydrate moieties of glycoproteins in established adjuvant induced arthritis. Agents Actions 25:63-70. crossref(new window)

Reed, S. G., S. Bertholet, R. N. Coler, and M. Friede. 2009. New horizons in adjuvants for vaccine development. Trends Immunol. 30:23-32. crossref(new window)

Richards, R. L., C. R. Alving, and N. M. Wassef. 1996. Liposomal subunit vaccines: Effects of lipid A and aluminum hydroxide on immunogenicity. J. Pharm. Sci 85:1286-1289. crossref(new window)

Ritchie, M. E., J. Silver, A. Oshlack, M. Holmes, D. Diyagama, A. Holloway, and G. K. Smyth. 2007. A comparison of background correction methods for two-colour microarrays. Bioinformatics 23:2700-2707. crossref(new window)

Shirley, M. W. and H. S. Lillehoj. 2012. The long view: A selective review of 40 years of coccidiosis research. Avian Pathol. 41:111-121. crossref(new window)

Stahl, P. D. and R. A. B. Ezekowitz. 1998. The mannose receptor is a pattern recognition receptor involved in host defense. Curr. Opin. Immunol. 10:50-55. crossref(new window)

Yamada, K., T. Nakamura, and H. Utsumi. 2006. Enhanced intraarticular free radical reactions in adjuvant arthritis rats. Free Radic. Res. 40:455-460. crossref(new window)

Yang, Y. W., C. A. Wu, and W. J. W. Morrow. 2004. Cell death induced by vaccine adjuvants containing surfactants. Vaccine 22:1524-1536. crossref(new window)

Yarovinsky, F., D. Zhang, J. F. Andersen, G. L. Bannenberg, C. N. Serhan, M. S. Hayden, S. Hieny, F. S. Sutterwala, R. A. Flavell, S. Ghosh, and A. Sher. 2005. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308:1626-1629. crossref(new window)

Yeatman, T. J. 2004. A renaissance for SRC. Nat. Rev. Cancer 4:470-480. crossref(new window)

Zamze, S., L. Martinez-Pomares, H. Jones, P. R. Taylor, R. J. Stillion, S. Gordon, and S. Y. C. Wong. 2002. Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor. J. Biol. Chem. 277:41613-41623. crossref(new window)