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Evaluation of Relative Bioavailability of 25-Hydroxycholecalciferol to Cholecalciferol for Broiler Chickens
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 Title & Authors
Evaluation of Relative Bioavailability of 25-Hydroxycholecalciferol to Cholecalciferol for Broiler Chickens
Han, J.C.; Chen, G.H.; Wang, J.G.; Zhang, J.L.; Qu, H.X.; Zhang, C.M.; Yan, Y.F.; Cheng, Y.H.;
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 Abstract
This study was conducted to evaluate the relative bioavailability (RBV) of 25-hydroxycholecalciferol (25-OH-) to cholecalciferol (vitamin ) in 1- to 21-d-old broiler chickens fed with calcium (Ca)- and phosphorus (P)-deficient diets. On the day of hatch, 450 female Ross 308 broiler chickens were assigned to nine treatments, with five replicates of ten birds each. The basal diet contained 0.50% Ca and 0.25% non-phytate phosphorus (NPP) and was not supplemented with vitamin D. Vitamin was fed at 0, 2.5, 5.0, 10.0, and , and 25-OH- was fed at 1.25, 2.5, 5.0, and . The RBV of 25-OH- was determined using vitamin as the standard source by the slope ratio method. Vitamin and 25-OH- intake was used as the independent variable for regression analysis. The linear relationships between the level of vitamin or 25-OH- and body weight gain (BWG) and the weight, length, ash weight, and the percentage of ash, Ca, and P in femur, tibia, and metatarsus of broiler chickens were observed. Using BWG as the criterion, the RBV value of 25-OH- to vitamin was 1.85. Using the mineralization of the femur, tibia, and metatarsus as criteria, the RBV of 25-OH- to vitamin ranged from 1.82 to 2.45, 1.86 to 2.52, and 1.65 to 2.05, respectively. These data indicate that 25-OH- is approximately 2.03 times as active as vitamin in promoting growth performance and bone mineralization in broiler chicken diets.
 Keywords
25-Hydroxycholecalciferol;Cholecalciferol;Relative Bioavailability;Growth;Bone;Broiler Chicken;
 Language
English
 Cited by
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