Advanced SearchSearch Tips
Effects of Supplemental Liquid DL-methionine Hydroxy Analog Free Acid in Diet on Growth Performance and Gastrointestinal Functions of Piglets
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effects of Supplemental Liquid DL-methionine Hydroxy Analog Free Acid in Diet on Growth Performance and Gastrointestinal Functions of Piglets
Kaewtapee, C.; Krutthai, N.; Bunchasak, C.;
  PDF(new window)
This study was conducted to determine the effect of dietary supplementation of liquid DL-methionine hydroxy analog free acid (DL-MHA) on growth performance and gastrointestinal conditions of piglets. One hundred and eighty crossbred barrow piglets (Large WhiteLandrace, body weight: ) were divided into three groups with ten replications of six piglets each. Piglets received DL-MHA in diet at a concentration of 0 (control group), 0.15%, or 0.24%. The results indicated that increasing the standardized ileal digestible (SID) of sulfur amino acids (SAA) to lysine (SID SAA:Lys) ratio by supplementation of DL-MHA tended to increase (quadratic; p<0.10) weight gain and ADG, and showed slightly greater (linear; p<0.10) gain:feed ratio. The pH in the diet and cecum linearly decreased (p<0.01), whereas pH in colon had a quadratic response (p<0.01) with increasing supplementation of DL-MHA. By greater supplementation of DL-MHA, the population of Lactobacillus spp. in rectum was likely to increase (quadratic; p<0.10), but Escherichia coli population in the diet was reduced (quadratic; p<0.05). Acetic acid concentration and total short-chain fatty acids in cecum linearly increased (p<0.05), whereas valeric acid in cecum quadratically increased (p<0.05) with increasing DL-MHA levels. Moreover, the villous height of the jejunum quadratically increased (p<0.01) as the supplementation of DL-MHA was increased. It is concluded that the addition of DL-MHA in diet improved the growth performance and the morphology of gastrointestinal tract of piglets.
Diet;Gastrointestinal Functions;Growth Performance;Liquid DL-methionine;Piglets;Short-chain Fatty Acids;
 Cited by
Bolduan, G., H. Jung, E. Schnabel, and R. Schneider. 1988. Recent advances in the nutrition of weaner pigs. Pig News Info. 9:381-385.

Bunchasak, C. 2014. Comparative bioefficacy of supplemental DL-2-hydroxy-4-[methyl] butanoic acid and DL-methionine on absorption, conversion and production performance. Danex Intercorporation Co., Ltd., Bangkok, Thailand.

Dibner, J. J. and P. Buttin. 2002. Use of organic acids as a model to study the impact of gut microflora on nutrition and metabolism. J. Appl. Poult. Res. 11:453-463. crossref(new window)

Dilger, R. N. and D. H. Baker. 2008. Cyst(e)ine imbalance and its effect on methionine precursor utilization in chicks. J. Anim. Sci. 86:1832-1840. crossref(new window)

Gaines, A. M., G. F. Yi, B. W. Ratliff, P. Srichana, D. C. Kendall, G. L. Allee, C. D. Knight, and K. R. Perryman. 2005. Estimation of the ideal ratio of true ileal digestible sulfur amino acids:lysine in 8- to 26-kg nursery pigs. J. Anim. Sci. 83:2527-2534. crossref(new window)

Kaewtapee, C., N. Krutthai, K. Poosuwan, T. Poeikhampha, S. Koonawootrittriron, and C. Bunchasak. 2010. Effects of adding liquid DL-methionine hydroxy analogue-free acid to drinking water on growth performance and small intestinal morphology of nursery pigs. J. Anim. Physiol. Anim. Nutr. 94:395-404.

Kim, B. G., M. D. Lindemann, M. Rademacher, J. J. Brennan, and G. L. Cromwell. 2006. Efficacy of DL-methionine hydroxy analog free acid and DL-methionine as methionine sources for pigs. J. Anim. Sci. 84:104-111. crossref(new window)

Kirchgessner, M. and F. X. Roth. 1982. Fumaric acid as a feed additive in pig nutrition. Pig News Info. 3:259-264.

Kongkaew, P. 2014. Comparative Effect of Methionine Sources and Total Sulfur Amino Acids to Lysine Ratios in Diets on Production Performance and Physiological Status in Intestinal Tract of Nursery Pigs. M.Sc. Thesis, Kasetsart University, Bangkok, Thailand.

Krutthai, N., C. Vajrabukka, K. Markvichitr, A. Choothesa, J. Thiengtham, S. Sawanon, C. Kaewtapee, and C. Bunchasak. 2015. Effect of source of methionine in broken rice-soybean diet on production performance, blood chemistry, and fermentation characteristics in weaned pigs. Czech J. Anim. Sci. 60:123-131.

Lambert, I. H. 2004. Regulation of the cellular content of the organic osmolyte taurine in mammalian cells. Neurochem. Res. 29:27-63. crossref(new window)

Macfarlane, G. T. and G. R. Gibson. 1995. Microbiological aspects of the production of short-chain fatty acids in the large bowel. In: Physiological and Clinical Aspects of Short-chain Fatty Acids (Eds. J. H. Cummings, J. L. Rombeau, and T. Sakata). Cambridge University Press, Cambridge, UK. pp. 87-105.

Macfarlane, S. and G. T. Macfarlane. 1995. Proteolysis and amino acid fermentation. In: Human Colonic Bacteria: Role in Nutrition, Physiology and Pathology (Eds. G. R. Gibson and G. T. Macfarlane). CRC Press, Boca Raton, FL, USA. pp. 75-100.

Mathew, A. G., A. L. Sutton, A. B. Scheidt, D. M. Forsyth, J. A. Patterson, and D. T. Kelly. 1991. Effects of a propionic acid containing feed additive on performance and intestinal microbial fermentation of the weanling pig. In: Digestive physiology in Pigs, Proceedings of the fifth international symposium on digestive physiology in the pig. EAAP Publication no. 54, Wageningen, The Netherlands. pp. 464-469.

Mroz, Z. 2005. Organic acids as potential alternatives to antibiotic growth promoters for pigs. Adv. Pork. Prod. 16:169-182.

National Research Council. 1998. Nutrient Requirements of Swine. 10th Ed. National Academy Press, Washington, DC, USA.

Peak, S. 2005. TSAA requirements for nursery and growing pigs. Adv. Pork. Prod. 16:101-107.

Poosuwan, K., C. Bunchasak, K. Prahkarnkaeo, S. Chansawang, and T. Poeikhampha. 2007. Effects of adding methionine hydroxy analog free acid to drinking water on growth performance and gastrointestinal functions of broiler chicks during starter period. In: Proceedings of International Conference on Integration of Science & Technology for Sustainable Development, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand. pp. 90-94.

Risley, C. R., E. T. Kornegay, M. D. Lindemann, C. M. Wood, and W. N. Eigel. 1992. Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs. J. Anim. Sci. 70:196-206. crossref(new window)

Roig-Perez, S., M. Moreto, and R. Ferrer. 2005. Transepithelial taurine transport in caco-2 cell monolayers. J. Membr. Biol. 204:85-92. crossref(new window)

Sakata, T., M. Adachi, M. Hashida, N. Sato, and T. Kojima. 1995. Effect of n-butyric acid on epithelial cell proliferation of pig colonic mucosa in short-term culture. Dtsch. Tierarztl. Wochenschr. 102:163-164.

SAS Institute Inc. 2008. SAS/STAT. User's Guide: Version 9.2. SAS Institute Inc., Cary, NC, USA.

Shoveller, A. K., B. Stoll, R. O. Ball, and D. G. Burrin. 2005. Nutritional and functional importance of intestinal sulfur amino acid metabolism. J. Nutr. 135:1609-1612.

Smith, E. A. and G. T. Macfarlane. 1997. Dissimilatory amino acid metabolism in human colonic bacteria. Anaerobe 3:327-337. crossref(new window)

Stein, H. H., B. Seve, M. F. Fuller, P. J. Moughan, and C. F. M. de Lange. 2007. Invited review: Amino acid bioavailability and digestibility in pig feed ingredients: Terminology and application. J. Anim. Sci. 85:172-180. crossref(new window)

Tan, H. M. 2006. Acidifiers: Synergy of acids make for better efficacy. Asian. Poul. Mag. 7:30-33.

Wallace, R. J. 1995. Biochemistry and microbiology in the rumen. In: Physiological and clinical aspects of short-chain fatty acids (Eds. J. H. Cummings, J. L. Rombeau, and T. Sakata). Cambridge University Press, Cambridge, UK. pp. 67-71.

Walsh, M. C., L. Peddireddi, and J. S. Radclife. 2004. Acidification of nursery diets and the role of diet buffering capacity. Swine Res. Rep. pp. 25-36.

Yen, J. T. 2001. Anatomy of the digestive system and nutritional physiology. In: Swine Nutrition, 2nd Ed. (Eds. A. J. Lewis and L. L. Southern). CRC press, Boca Raton, FL, USA. pp. 31-63.