Effects of 60-Hz Magnetic Fields on DNA Damage Responses in HT22 Mouse Hippocampal Cell Lines

Title & Authors
Effects of 60-Hz Magnetic Fields on DNA Damage Responses in HT22 Mouse Hippocampal Cell Lines
Mun, Gil-Im; Lee, Seungwoo; Kim, Nam; Lee, Yun-Sil;

Abstract
Previously, we investigated extremely low-frequency magnetic fields (ELF-MFs) on diverse DNA damage responses, such as phosphorylated H2AX ($\small{{\gamma}H2AX}$), comet tail moments, and aneuploidy production in several non-tumorigenic epithelial or fibroblast cell lines. However, the effect of ELF-MF on DNA damage responses in neuronal cells may not be well evaluated. Here, we investigated the effects of ELF-MF on the DNA damage responses in HT22 non-tumorigenic mouse neuronal cells. Exposure to a 60-Hz, 2 mT ELF-MF did not produce any increased $\small{{\gamma}H2AX}$ expression, comet tail moments, or aneuploidy formation. However, 2 mT ELF-MF transiently increased the cell number. From the results, ELF-MF could affect the DNA damage responses differently, depending on the cell lines.
Keywords
Aneuploidy;Cell Lines;Comet Tail;Extremely Low Frequency;$\small{{\gamma}H2AX}$;
Language
English
Cited by
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