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Effects of 915 MHz Radiofrequency Identification Electromagnetic Field Exposure on Neuronal Precursor Cells in the Dentate Gyrus of Adult Rat Brains
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 Title & Authors
Effects of 915 MHz Radiofrequency Identification Electromagnetic Field Exposure on Neuronal Precursor Cells in the Dentate Gyrus of Adult Rat Brains
Kim, Hye Sun; Lee, Yu Hee; Lee, Yun-Sil; Choi, Hyung-Do; Kwon, Jong Hwa; Pack, Jeong-Ki; Kim, Nam; Ahn, Young Hwan;
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To explore the effects of radiofrequency electromagnetic field on the fate of neuronal cells, we investigated whether exposure to 915 MHz radiofrequency identification (RFID) caused morphological changes in neuronal cells in rat hippocampal dentate gyrus (DG). A reverberation chamber was used as a whole-body RFID exposure system. Rats were assigned to two groups: sham- and RFID-exposed groups. Rats in the RFID-exposed group were exposed to RFID at 4 W/kg specific absorption rate (SAR) for 8 hours daily, 5 days per week, for 2 weeks. Morphological evaluation of DG was performed using immunohistochemistry with doublecortin (DCX) as a neuronal precursor cell marker and neuronal nuclei (NeuN) as a mature neuronal cell marker. No significant morphological changes in DCX+ or NeuN+ cells in the DG of RFID-exposed rats were observed. These results suggest that RFID exposure induces no significant change in DCX+ neuronal precursor or NeuN+ neuronal cells in DG of rats.
915 MHz RFID;DCX;Dentate Gyrus;NeuN;
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M. Feychting, A. Ahlbom, and L. Kheifets, "EMF and health," Annual Review of Public Health, vol. 26, pp. 165-189, 2005. crossref(new window)

A. E. Pereda, "Electrical synapses and their functional interactions with chemical synapses," Nature Reviews Neuroscience, vol. 15, no. 4, pp. 250-263, 2014. crossref(new window)

N. D. Volkow, D. Tomasi, G. J. Wang, P. Vaska, J. S. Fowler, F. Telang, D. Alexoff, J. Logan, and C. Wong, "Effects of cell phone radiofrequency signal exposure on brain glucose metabolism," JAMA, vol. 305, no. 8, pp. 808-813, 2011. crossref(new window)

S. Xu, W. Ning, Z. Xu, S. Zhou, H. Chiang, and J. Luo, "Chronic exposure to GSM 1,800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons," Neuroscience Letters, vol. 398, no. 3, pp. 253-257, 2006. crossref(new window)

D. N. Abrous, M. Koehl, and M. Le Moal, "Adult neurogenesis: from precursors to network and physiology," Physiological Reviews, vol. 85, no. 2, pp. 523-569, 2005. crossref(new window)

Y. Yagita, K. Kitagawa, T. Sasaki, Y. Terasaki, K. Todo, E. Omura-Matsuoka, M. Matsumoto, and M. Hori, "Postischemic exercise decreases neurogenesis in the adult rat dentate gyrus," Neuroscience Letters, vol. 409, no. 1, pp. 24-29, 2006. crossref(new window)

T. H. Lee, C. H. Lee, I. H. Kim, B. C. Yan, J. H. Park, S. H. Kwon, O. K. Park, J. H. Ahn, J. H. Cho, M. H. Won, and S. K. Kim, "Effects of ADHD therapeutic agents, methylphenidate and atomoxetine, on hippocampal neurogenesis in the adolescent mouse dentate gyrus," Neuroscience Letters, vol. 524, no. 2, pp. 84-88, 2012. crossref(new window)

C. Utsugi, S. Miyazono, K. Osada, H. Sasajima, T. Noguchi, M. Matsuda, and M. Kashiwayanagi, "Hard-diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft-diet feeding," PLoS One, vol. 9, no. 5, p. e97309, 2014. crossref(new window)

M. Bergami, G. Masserdotti, S. G. Temprana, E. Motori, T. M. Eriksson, J. Gobel, S. M. Yang, K. Conzelmann, A. F. Schinder, M. Gotz, and B. Berninger, "A critical period for experience-dependent remodeling of adult-born neuron connectivity," Neuron, vol. 85, no. 4, pp. 710-717, 2015. crossref(new window)

J. Orendacova, E. Racekova, M. Orendac, M. Martoncikova, K. Saganova, K. Lievajova, H. Abdiova, J. Labun, and J. Galik, "Immunohistochemical study of postnatal neurogenesis after whole-body exposure to electromagnetic fields: evaluation of age- and dose-related changes in rats," Cellular and Molecular Neurobiology, vol. 29, no. 6-7, pp. 981-990, 2009. crossref(new window)

E. Odaci, O. Bas, and S. Kaplan, "Effects of prenatal exposure to a 900 MHz electromagnetic field on the dentate gyrus of rats: a stereological and histopathological study," Brain Research, vol. 1238, pp. 224-229, 2008. crossref(new window)

M. O. Kim, H. Jung, S. C. Kim, J. K. Park, and Y. K. Seo, "Electromagnetic fields and nanomagnetic particles increase the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells," International Journal of Molecular Medicine, vol. 35, no. 1, pp. 153-160, 2015. crossref(new window)

Y. Seong, J. Moon, and J. Kim, "Egr1 mediated the neuronal differentiation induced by extremely low-frequency electromagnetic fields," Life Sciences, vol. 102, no. 1, pp. 16-27, 2014. crossref(new window)

H. J. Kim, J. Jung, J. H. Park, J. H. Kim, K. N. Ko, and C. W. Kim, "Extremely low-frequency electromagnetic fields induce neural differentiation in bone marrow derived mesenchymal stem cells," Experimental Biology and Medicine, vol. 238, no. 8, pp. 923-931, 2013. crossref(new window)

J. E. Park, Y. K. Seo, H. H. Yoon, C. W. Kim, J. K. Park, and S. Jeon, "Electromagnetic fields induce neural differentiation of human bone marrow derived mesenchymal stem cells via ROS mediated EGFR activation," Neurochemistry International, vol. 62, no. 4, pp. 418-424, 2013. crossref(new window)

J. P. Shah, P. Midkiff, P. C. Brandt, and B. F. Sisken, "Growth and differentiation of PC6 cells: the effects of pulsed electromagnetic fields (PEMF)," Bioelectromagnetics, vol. 22, no. 4, pp. 267-271, 2001. crossref(new window)

M. Y. Macias, J. H. Battocletti, C. H. Sutton, F. A. Pintar, and D. J. Maiman, "Directed and enhanced neurite growth with pulsed magnetic field stimulation," Bioelectromagnetics, vol. 21, no. 4, pp. 272-286, 2000. crossref(new window)

G. Del Vecchio, A. Giuliani, M. Fernandez, P. Mesirca, F. Bersani, R. Pinto, L. Ardoino, G. A. Lovisolo, L. Giardino, and L. Calza, "Continuous exposure to 900 MHz GSM-modulated EMF alters morphological maturation of neural cells," Neuroscience Letters, vol. 455, no. 3, pp. 173-177, 2009. crossref(new window)

H. S. Kim, Y. J. Kim, Y. H. Lee, Y. S. Lee, H. D. Choi, J. K. Pack, N. Kim, and Y. H. Ahn, "Effect of whole-body exposure to the 848.5 MHz code division multiple access (CDMA) electromagnetic field on adult neurogenesis in the young, healthy rat brain," International Journal of Radiation Biology, vol. 91, no. 4, pp. 354-359, 2015. crossref(new window)

H. S. Kim, M. J. Paik, Y. J. Kim, G. Lee, Y. S. Lee, H. D. Choi, B. C. Kim, J. K. Pack, N. Kim, and Y. H. Ahn, "Effects of whole-body exposure to 915 MHz RFID on secretory functions of the thyroid system in rats," Bioelectromagnetics, vol. 34, no. 7, pp. 521-529, 2013.

K. B. Jung, T. H. Kim, J. L. Kim, H. J. Doh, Y. C. Chung, J. H. Choi, and J. K. Pack, "Development and validation of reverberation-chamber type whole-body exposure system for mobile-phone frequency," Electromagnetic Biology and Medicine, vol. 27, no. 1, pp. 73-82, 2008. crossref(new window)

H. S. Kim, Y. S. An, M. J. Paik, Y. S. Lee, H. D. Choi, B. C. Kim, J. K. Pack, N. Kim, and Y. H. Ahn, "The effects of exposure to 915 MHz radiofrequency identification on cerebral glucose metabolism in rat: a [F-18] FDG micro-PET study," International Journal of Radiation Biology, vol. 89, no. 9, pp. 750-755, 2013. crossref(new window)

J. C. Fiala and K. M. Harris, "Extending unbiased stereology of brain ultrastructure to three-dimensional volumes," Journal of the American Medical Informatics Association, vol. 8, no. 1, pp. 1-16, 2001. crossref(new window)

M. J. West, L. Slomianka, and H. J. Gundersen, "Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator," Anatomical Record, vol. 231, no. 4, pp. 482-497, 1991. crossref(new window)

O. F. Sonmez, E. Odaci, O. Bas, and S. Kaplan, "Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field," Brain Research, vol. 1356, pp. 95-101, 2010. crossref(new window)

L. G. Salford, A. E. Brun, J. L. Eberhardt, L. Malmgren, and B. R. Persson, "Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones," Environmental Health Perspectives, vol. 111, no. 7, pp. 881-883, 2003. crossref(new window)

H. Masuda, A. Ushiyama, M. Takahashi, J. Wang, O. Fujiwara, T. Hikage, T. Nojima, K. Fujita, M. Kudo, and C. Ohkubo, "Effects of 915 MHz electromagnetic-field radiation in TEM cell on the blood-brain barrier and neurons in the rat brain," Radiation Research, vol. 172, no. 1, pp. 66-73, 2009. crossref(new window)

T. Kumlin, H. Iivonen, P. Miettinen, A. Juvonen, T. van Groen, L. Puranen, R. Pitkaaho, J. Juutilainen, and H. Tanila, "Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats," Radiation Research, vol. 168, no. 4, pp. 471-479, 2007. crossref(new window)

T. H. Kim, T. Q. Huang, J. J. Jang, M. H. Kim, H. J. Kim, J. S. Lee, J. K. Pack, J. S. Seo, and W. Y. Park, "Local exposure of 849 MHz and 1,763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain," Experimental and Molecular Medicine, vol. 40, no. 3, pp. 294-303, 2008. crossref(new window)

B. Cuccurazzu, L. Leone, M. V. Podda, R. Piacentini, E. Riccardi, C. Ripoli, G. B. Azzena, and C. Grassi, "Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice," Experimental Neurology, vol. 226, no. 1, pp. 173-182, 2010. crossref(new window)

M. S. Rao and A. K. Shetty, "Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus," European Journal of Neuroscience, vol. 19, no. 2, pp. 234-246, 2004. crossref(new window)

B. Weber and L. F. Barros, "The astrocyte: powerhouse and recycling center," Cold Spring Harbor Perspectives in Biology, 2015. crossref(new window)

G. Gittins and P. J. Harrison, "Neuronal density, size and shape in the human anterior cingulate cortex: a comparison of Nissl and NeuN staining," Brain Research Bulletin, vol. 63, no. 2, pp. 155-160, 2004. crossref(new window)

R. J. Mullen, C. R. Buck, and A. M. Smith, "NeuN, a neuronal specific nuclear protein in vertebrates," Development, vol. 116, no. 1, pp. 201-211, 1992.