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Anti-Obesity Effects of Starter Fermented Kimchi on 3T3-L1 Adipocytes
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  • Journal title : Preventive Nutrition and Food Science
  • Volume 20, Issue 4,  2015, pp.298-302
  • Publisher : The Korean Society of Food Science and Nutrition
  • DOI : 10.3746/pnf.2015.20.4.298
 Title & Authors
Anti-Obesity Effects of Starter Fermented Kimchi on 3T3-L1 Adipocytes
Lee, Kyung-Hee; Song, Jia-Le; Park, Eui-Seong; Ju, Jaehyun; Kim, Hee-Young; Park, Kun-Young;
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The anti-obesity effects of starter (Leuconostoc mesenteroides+Lactobacillus plantarum) fermented kimchi on 3T3-L1 adipocyte were studied using naturally fermented kimchi (NK), a functional kimchi (FK, NK supplemented with green tea), and FK supplemented with added starters (FKS). Oil red O staining and cellular levels of triglyceride (TG) and glycerol were used to evaluate the in vitro anti-obesity effects of these kimchis in 3T3-L1 cells. The expressions of adipogenesis/lipogenesis-related genes of peroxisome proliferator-active receptor (PPAR)-, CCAAT/enhance-binding protein (C/EBP)-, and fatty acid synthase (FAS) were determined by RT-PCR. Kimchis, especially FKS, markedly decreased TG levels and increased levels of intracellular glycerol and lipid lipolysis. In addition, FKS also reduced the mRNA levels of PPAR-, C/EBP-, and FAS, which are related to adipogenesis/lipogenesis in 3T3-L1 cells. These results suggest the anti-obesity effects of FKS were to due to enhanced lipolysis and reduced adipogenesis/lipogenesis in 3T3-L1 adipocytes.
kimchi;starters;antiobesity;3T3-L1 cells;
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