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Decomposition of Antibiotics (Cefaclor) by Ionizing Radiation: Optimization and Modeling Using a Design of Experiment (DOE) Based on Statistical Analysis
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  • Journal title : Environmental Engineering Research
  • Volume 14, Issue 2,  2009, pp.81-87
  • Publisher : Korean Society of Environmental Engineering
  • DOI : 10.4491/eer.2009.14.2.081
 Title & Authors
Decomposition of Antibiotics (Cefaclor) by Ionizing Radiation: Optimization and Modeling Using a Design of Experiment (DOE) Based on Statistical Analysis
Yu, Seung-Ho; Chang, Soon-Woong; Lee, Si-Jin; Cho, Il-Hyoung;
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 Abstract
The decomposition of antibiotics (cefaclor) by gamma irradiation in aqueous solutions was experimentally evaluated. To obtain a mutual interaction between two factors (antibiotics concentrations and radiation doses) and to optimize these factors during the process, experimental design and statistical analysis were employed. The decomposition capability of the gamma radiation was also mathematically described as a function of cefaclor concentration and gamma-ray dose using the statistical analysis. The results showed that the cefaclor concentration () in the response (Reduction of cefaclor concentration) and gamma-ray dose () in the response (Removal efficiency (%) of cefaclor concentration) exhibited a significantly positive effect, whereas gamma-ray dose () in the response showed a significantly negative effect. The estimated ridge of maximum responses and optimal conditions for :(,)
 Keywords
Antibiotics;Cefaclor;Gamma radiation;Experimental design;Statistical analysis;
 Language
English
 Cited by
 References
1.
Calza, P., Sakkas, V. A., Medana, C., Baiocchi, C., Dimou, A., Pelizzetti, E., and Albanis, T., "Photocatalytic degrada-tion study of diclofenac over aqueous $TiO_2$ suspensions," Applied Catalysis. B: Environment, 67, 197-205 (2006) crossref(new window)

2.
Carballa, M., Omil, F., Lema, J. M., Llompart, M., Garcia-Jares, C., Rodriguez, I., Gomez, M., and Temes, T., "Beha-vior of pharmaceuticals, cosmetics and hormones in a sew-age treatment plant," Water Res., 38(12), 2918-2926 (2004) crossref(new window)

3.
Costanzo, S. D., Murby, J., and Bates, J., "Ecosystem respo-nse to antibiotics entehng the aquatic environment," Mar. Pollut. Bull., 51(1-4), 218-223 (2005) crossref(new window)

4.
Batt, A. L., Bruce, I. B., and Aga, D. S., "Evaluating the vulnerability of surface waters to antibiotic contaminationfrom varying wastewater treatment plant discharges," Environ. Pollut., 142(2), 295-302 (2006) crossref(new window)

5.
Jorgensen, S. E. and Hallmg-Sorensen, B., "Drugs in the environment," Chemosphere, 40(7), 691-699 (2000) crossref(new window)

6.
Gobel, A., McArdell, C. S., Suter, M. J.-F., and Giger, W., "Trace determination of macrolide and sulfonamide antimic-robials, a human sulfonamide metabolite, and thmethoprim in wastewater using liquid chromatography coupled to elec-trospray tandem mass spectrometry," Anal. Chem., 76(16), 4756-4764 (2004) crossref(new window)

7.
Diaz-Cruz, M. S., Lopez de Alda, M. J., and Barcelo, D., "Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge," Trends in Analytical Chemistry, 22(6), 340-351 (2003) crossref(new window)

8.
Heberer, T., "Tracking persistent pharmaceutical residues from municipal sewage to drinking water," J. Hydrol., 266(3-4), 175-189 (2002) crossref(new window)

9.
Hirsch, R., Ternes, T., Haberer, K., and Kratz, K. L., "Occu-rrence of antibiotics in the aquatic environment," Sci. of the Total Environment, 225, 109-118 (1999) crossref(new window)

10.
Cho, I. H. and Zoh, K. D., "Photocatalytic Degradation of azo dye (Reactive Red 120) in $TiO_2/UV$ System: Optimization and Modeling using a Response Surface Methodology (RSM) based on the Central Composite Design," Dye and Pigments, 75(3), 533-543 (2007) crossref(new window)

11.
Elibol, M., "Optimization of medium composition for acti-norhodin production by Streptomyces coelicolor A3(2) with response surface methodology," Proc. Biochem., 39, 1057-1062 (2004) crossref(new window)

12.
Olivera, F. C., Caron, G. R., and Brandelli, A., "Bacteriocin production by Bacillus licheniformis strain P40 in cheese whey using response surface methodology," Biochem. Eng. J., 21, 53-58 (2004) crossref(new window)

13.
Mamani, M. C. V., Farfan, J. A., Reyes, F. G. R. R., and Rath, S., "Simultaneous determination of tetracyclines in pharmaceuticals by CZE using expehmental design," Talanta, 70, 236-243 (2006) crossref(new window)

14.
Joshi, S., "HPLC separation of antibiotics present in formulated and unformulated samples," J. Pharm. Biomed. Anal., 28, 795-809 (2002) crossref(new window)

15.
Khan, S. J. and Ongerth, J. E., "Estimation of pharmaceutical residues in primary and secondary sewage sludge based on quantities of use and fugacity modeling," Water Sci. Technol, 46(3), 105-113 (2002)

16.
Park, J., An approach for developing aquatic environmental risk assessment framework for pharmaceuticals in Korea, A report from Korea Environment Institute, K-EI-RE-05

17.
Bielski, B. H. J., Cabelli, D. E., and Arudi, R. L., "Reactivity of $HO_2/O_2$ - radicals in aqueous solution," J. Phys. Chem., 14(4), 1041-1100 (1985)

18.
Buxton, G. V., Langan, J. R., and Smith, J. R. L., "A radiation chemical study ofthe oxidation of hydroxycyclohexa-dienyl radicals, J. Phys. Chem., 90, 6309-6313 (1986) crossref(new window)

19.
Zona, R. and Solar, S., "Oxidation of 2,4-dichlorophenoxy-acetic acid by ionizing radiation: degradation, detoxification and mineralization," Radiat. Phys. Chem., 66(2), 137-143 (2003) crossref(new window)

20.
Box, G. and Hunter, W. G., Statistics for Expehmenters:An Introduction to Design, Data Analysis, and Model Building, Wiley, NJ(1987)