JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Distinct Oxidative Damage of Biomolecules by Arrays of Metals Mobilized from Different Types of Airborne Particulate Matters: SRM1648, Fine (PM2.5), and Coarse (PM10) Fractions
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Environmental Engineering Research
  • Volume 18, Issue 3,  2013, pp.139-143
  • Publisher : Korean Society of Environmental Engineering
  • DOI : 10.4491/eer.2013.18.3.139
 Title & Authors
Distinct Oxidative Damage of Biomolecules by Arrays of Metals Mobilized from Different Types of Airborne Particulate Matters: SRM1648, Fine (PM2.5), and Coarse (PM10) Fractions
Park, Yong Jin; Lim, Leejin; Song, Heesang;
  PDF(new window)
 Abstract
This study was performed to examine the in vitro toxicities which are incurred due to the mobilization metals from standard reference material (SRM) 1648, fine (), and coarse () particulate matter collected in Seoul metropolitan area. DNA single strand breaks of approximately 74% and 62% for and for , respectively, were observed in the presence of chelator (EDTA or citrate)/reductant (ascorbate), as compared to the control by 2% without chelator or reductant. induced about 40% more carbonyl formation with proteins in the presence of EDTA/ascorbate than . Therefore, more damage to biomolecules was incurred upon exposure to than to . The treatment of a specific chelator, desferrioxamine, to the reaction mixture containing chelator plus reductant decreased the extent of damage to DNA to the level of the control, but did not substantially decrease the extent of damage to proteins. This suggests that different arrays of metals were involved in the oxidation of DNA and proteins.
 Keywords
Carbonylation;Particulate matter;Reactive oxygen species;Single strand breaks;Transition metals;
 Language
English
 Cited by
1.
Reaction mechanisms for dithiothreitol as a measure of particulate matter induced oxidative potential activity by density functional theory,;;

The Korean Journal of Chemical Engineering, 2014. vol.31. 7, pp.1115-1119 crossref(new window)
1.
Reaction mechanisms for dithiothreitol as a measure of particulate matter induced oxidative potential activity by density functional theory, Korean Journal of Chemical Engineering, 2014, 31, 7, 1115  crossref(new windwow)
2.
The effect of climate and meteorological changes on particulate matter in Pune, India, Environmental Monitoring and Assessment, 2015, 187, 7  crossref(new windwow)
 References
1.
Groneberg DA, Morfeld P, Kraus T, et al. Health effects of particulate matter exposure: current scientific knowledge. Pneumologie 2009;63:363-368. crossref(new window)

2.
Danielsen PH, Moller P, Jensen KA, et al. Oxidative stress, DNA damage, and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines. Chem. Res. Toxicol. 2011;24:168-184. crossref(new window)

3.
Halliwell B, Gutteridge JM. Free radicals in biology and medicine. 2nd ed. New York: Clarendon Press; 1989.

4.
Campen MJ, Nolan JP, Schladweiler MC, et al. Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: a potential interaction between nickel and vanadium sulfate. Toxicol. Sci. 2001;64:243-252. crossref(new window)

5.
Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology 2011;283:65-87. crossref(new window)

6.
Stadtman ER, Berlett BS. Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab. Rev. 1998;30:225-243. crossref(new window)

7.
Levine RL, Williams JA, Stadtman ER, Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 1994;233:346-357. crossref(new window)

8.
Itziou A, Kaloyianni M, Dimitriadis VK. In vivo and in vitro effects of metals in reactive oxygen species production, protein carbonylation, and DNA damage in land snails Eobania vermiculata. Arch. Environ. Contam. Toxicol. 2011;60:697-707. crossref(new window)

9.
Forbes LJ, Kapetanakis V, Rudnicka AR, et al. Chronic exposure to outdoor air pollution and lung function in adults. Thorax 2009;64:657-663. crossref(new window)

10.
Pope CA 3rd, Burnett RT, Krewski D, et al. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation 2009;120:941-948. crossref(new window)

11.
Farina F, Sancini G, Mantecca P, Gallinotti D, Camatini M, Palestini P. The acute toxic effects of particulate matter in mouse lung are related to size and season of collection. Toxicol. Lett. 2011;202:209-217. crossref(new window)

12.
Smith KR, Aust AE. Mobilization of iron from urban particulates leads to generation of reactive oxygen species in vitro and induction of ferritin synthesis in human lung epithelial cells. Chem. Res. Toxicol. 1997;10:828-834. crossref(new window)

13.
Song HS, Bang WG, Chung N, Cho YS, Kim YS, Cho MH. Effect of chelators and reductants on the mobilization of metals from ambient particulate matter. Environ. Sci. Technol. 2003;37:3531-3536. crossref(new window)

14.
Chaston TB, Richardson DR. Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity. Am. J. Hematol. 2003;73:200-210. crossref(new window)

15.
Doulias PT, Christoforidis S, Brunk UT, Galaris D. Endosomal and lysosomal effects of desferrioxamine: protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell-cycle arrest. Free Radic. Biol. Med. 2003;35:719-728. crossref(new window)

16.
Barbouti A, Doulias PT, Zhu BZ, Frei B, Galaris D. Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage. Free Radic. Biol. Med. 2001;31:490-498. crossref(new window)

17.
Seaton A, MacNee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet 1995;345:176-178. crossref(new window)