Publisher : Korean Society of Environmental Engineering
DOI : 10.4491/eer.2014.S1.006
Title & Authors
Method development and initial results of testing for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in waterproof sunscreens Keawmanee, Sasipin; Boontanon, Suwanna Kitpati; Boontanon, Narin;
Perfluorooctane sulfonate (PFOS) and Perfluorooctanoic acid (PFOA) are persistent environmental pollutants, extremely stable, and possibly adversely affect human health. They are widely used in many industries and consumer goods, including sunscreen products. These substances are stable chemicals made of long carbon chains, having both lipid- and water-repellent qualities. The research objectives are (1) to find the most effective method for the preparation of semi-liquid samples by comparing solid phase extraction (SPE) and centrifugation after Pressurized liquid extraction (PLE), and (2) to determine the contamination levels of PFOS and PFOA in waterproof sunscreen samples. All sunscreen samples were analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Sunscreen samples were purchased from domestic and international brands sold in Thailand. Special chemical properties were considered for the selection of samples, e.g., those found in waterproof, sweat resistant, water resistant, and non-stick products. Considering the factors of physical properties, e.g., operation time, chemical consumption, and recovery percentage for selecting methods to develop, the centrifugation method using 2 mL of extracted sample with the conditions of 12,000 rpm and for 1 hour after PLE was chosen. The highest concentrations of PFOS and PFOA were detected at 0.0671 ng/g and 21.0644 ng/g, respectively. Even though present concentrations are found at ng/g levels, the daily use of sunscreen products is normally several grams. Therefore, a risk assessment of PFOS and PFOA contamination in sunscreen products is an important concern, and more attention needs to be paid to the long-term effects on human health.
Centrifugation;LC-MS/MS;Personal care products;Perfluorinated compounds;Pressurized liquid extraction (PLE);Solid phase extraction (SPE);
Elevated levels of short carbon-chain PFCAs in breast milk among Korean women: Current status and potential challenges, Environmental Research, 2016, 148, 351
Updated national emission of perfluoroalkyl substances (PFASs) from wastewater treatment plants in South Korea, Environmental Pollution, 2017, 220, 298
Jogsten IE, Perello G, Llebaria X, et al. Exposure to perfluorinated compounds in Catalonia, Spain, through consumption of various raw and cooked foodstuffs, including packaged food. Food Chem. Toxicol. 2009;47:1577-1583.
Liu X, Jin Y, Liu W, Wang F, Hao S. Possible mechanism of perfluorooctane sulfonate and perfluorooctanoate on the release of calcium ion from calcium stores in primary cultures of rat hippocampal neurons. Toxicol. In Vitro 2011;25: 1294-1301.
Loccisano AE, Campbell JL, Andersen ME, Clewell HJ. Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model. Regul. Toxicol. Pharmacol. 2011;59:157-175.
Florentin A, Deblonde T, Diguio N, Hautemaniere A, Hartemann P. Impacts of two perfluorinated compounds (PFOS and PFOA) on human hepatoma cells: Cytotoxicity but no genotoxicity? Inter. J. Hyg. Environ. Health. 2011;214:493-499.
Jin YH, Liu W, Sato I, Nakayama SF, Sasaki K, Saito N, Tsuda S. PFOS and PFOA in environmental and tap water in China. Chemosphere 2009;77:605-611.
Wang T, Khim JS, Chen C, et al. Perfluorinated compounds in surface waters from Northern China: Comparison to level of industrialization. Environ. Inter. 2012;42:37-46.
Lein NPH, Fujii S, Tanaka S, Nozoe M, Tanaka H. Contamination of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in surface water of the Yodo River basin (Japan). Desalination 2008;226:338-347.
Guerranti C, Perra G, Corsolini S, Focardi SE. Pilot study on levels of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in selected foodstuffs and human milk from Italy. Food Chem. 2013;140:197-203.
Directive E. Directive 2006/122/ECOF. the European Parliament and of the Council of 12 December 2006. Official J. Eur. Union. L 372.
Zafeiraki E, Costopoulou D, Vassiliadou I, Bakeas E, Leondiadis L. Determination of perfluorinated compounds (PFCs) in various foodstuff packaging materials used in the Greek market. Chemosphere 2014;94:169-176.
Llorca M, Farre M, Pico Y, Barcelo D. Development and validation of a pressurized liquid extraction liquid chromatography-tandem mass spectrometry method for perfluorinated compounds determination in fish. J. Chromatogra. A 2009;1216: 7195-7204.
Poothong S, Boontanon SK, Boontanon N. Determination of perfluorooctane sulfonate and perfluorooctanoic acid in food packaging using liquid chromatography coupled with tandem mass spectrometry. J. Hazard. Mater. 2012;205-206:139-143.
Ballesteros-Gomez A, Rubio S, van Leeuwen S. Tetrahydrofuran -water extraction, in-line clean-up and selective liquid chromatography/ tandem mass spectrometry for the quantitation of perfluorinated compounds in food at the low picogram per gram level. J. Chromatogr. A 2010;1217:5913-5921.
Ropers MH, Durand S, Veyrand B, et al. Contamination of food by fluorinated surfactants - Distribution in emulsions and impact on the interfacial protein behaviour. Food Hydrocoll. 2009;23:1149-1155.
Fujii Y, Harada KH, Koizumi A. Occurrence of perfluorinated carboxylic acids (PFCAs) in personal care products and compounding agents. Chemosphere 2013;93:538-544.