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Adult stem cell lineage tracing and deep tissue imaging
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  • Journal title : BMB Reports
  • Volume 48, Issue 12,  2015, pp.655-667
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.12.249
 Title & Authors
Adult stem cell lineage tracing and deep tissue imaging
Fink, Juergen; Andersson-Rolf, Amanda; Koo, Bon-Kyoung;
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Lineage tracing is a widely used method for understanding cellular dynamics in multicellular organisms during processes such as development, adult tissue maintenance, injury repair and tumorigenesis. Advances in tracing or tracking methods, from light microscopy-based live cell tracking to fluorescent label-tracing with two-photon microscopy, together with emerging tissue clearing strategies and intravital imaging approaches have enabled scientists to decipher adult stem and progenitor cell properties in various tissues and in a wide variety of biological processes. Although technical advances have enabled time-controlled genetic labeling and simultaneous live imaging, a number of obstacles still need to be overcome. In this review, we aim to provide an in-depth description of the traditional use of lineage tracing as well as current strategies and upcoming new methods of labeling and imaging.
Adult stem cells;Advanced imaging;Intravital imaging;Lineage tracing;Tissue clearing;
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Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair, Stem Cell Reviews and Reports, 2016, 12, 4, 421  crossref(new windwow)
Deep insights: intravital imaging with two-photon microscopy, Pflügers Archiv - European Journal of Physiology, 2016, 468, 9, 1505  crossref(new windwow)
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