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InSAC: A novel sub-nuclear body essential for Interleukin-6 and -10 RNA processing and stability
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  • Journal title : BMB Reports
  • Volume 48, Issue 5,  2015, pp.239-240
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.5.060
 Title & Authors
InSAC: A novel sub-nuclear body essential for Interleukin-6 and -10 RNA processing and stability
Lee, Sungwook; Park, Boyoun;
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 Abstract
Dysregulation of cytokine expression causes inflammatory diseases or chronic infection conditions. We have identified that Tat-activating regulatory DNA-binding protein-43 (TDP-43) is involved in cytokine RNA processing in order to promote an optimal immune response. The interaction of TDP-43 with spliceosomal components from the Cajal body leads to the formation of a novel sub-nuclear body called the Interleukin (IL)-6 and IL-10 Splicing Activating Compartment (InSAC). TDP-43 binds to the IL-6 and IL-10 RNAs in a sequence-dependent manner. In cell-based studies, we observed that lipopoly-saccharide (LPS) stimulation induces the formation of the InSAC through TDP-43 ubiquitination, thereby influencing the processing and expression levels of IL-6 RNA. Moreover, TDP-43 knockdown in vivo results in a decrease in IL-6 production and its RNA splicing and stability. Thus, these findings demonstrate that the InSAC is linked to the activation and modulation of the immune response. [BMB Reports 2015; 48(5): 239-240]
 Keywords
TDP-43;Cytokine;IL-6;Nuclear body;RNA processing;
 Language
English
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