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The effect of baicalin in a mouse model of retinopathy of prematurity
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  • Journal title : BMB Reports
  • Volume 48, Issue 5,  2015, pp.271-276
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.5.131
 Title & Authors
The effect of baicalin in a mouse model of retinopathy of prematurity
Jo, Hyoung; Jung, Sang Hoon; Yim, Hye Bin; Lee, Sung Jin; Kang, Kui Dong;
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 Abstract
Baicalin is a flavonoid derived from the dried root of Scutellaria baicalensis. In this study, oxygen-induced retinopathy was used to characterize the anti-angiogenic properties of baicalin in mice. Pups were exposed to a hyperbaric oxygen environment to induce retinal angiogenesis and were subjected to intraperitoneal injection of baicalin. Avascular area, neovascular tufts, and neovascular lumens were quantified from digital images. Compared to the vehicle, baicalin clearly reduced the central avascular zone and the number of neovascular tufts and lumens. High-dose baicalin (10 mg/kg) significantly reduced the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, angiotensin II, and vascular endothelial growth factor (VEGF). These results show that baicalin is a powerful antiangiogenic compound that attenuates new vessel formation in the retina after systemic administration, and is a candidate substance for therapeutic inhibition of retinal angiogenesis. [BMB Reports 2015; 48(5): 271-276]
 Keywords
Angiogenesis;Angiotensin II;Baicalin;Oxygen-induced retinopathy;VEGF;
 Language
English
 Cited by
1.
Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9, Evidence-Based Complementary and Alternative Medicine, 2016, 2016, 1  crossref(new windwow)
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