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Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
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  • Journal title : BMB Reports
  • Volume 48, Issue 5,  2015, pp.283-288
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.5.190
 Title & Authors
Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
Noh, Kyung Tae; Cho, Joon; Chun, Sung Hak; Jang, Jong-Hwa; Cha, Gil Sun; Jung, In Duk; Jang, Dong Deuk; Park, Yeong-Min;
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We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regulates naive CD8+ T-cell polarization by modulating GSK-3β activity in IFN-γ-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8+ T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-γ-induced TTS expression in a GSK-3β-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation. [BMB Reports 2015; 48(5): 283-288]
Bone marrow-derived dendritic cells;CD8+ T cell;Glycogen synthase kinase 3;Resveratrol;Tryptophanyl-tRNA synthetase;
 Cited by
In VitroEffects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity, Journal of Immunology Research, 2016, 2016, 1  crossref(new windwow)
Banchereau J, Briere F, Caux C et al (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18, 767-811 crossref(new window)

Mellor AL and Munn DH (2004) IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4, 762-774 crossref(new window)

Lob S, Konigsrainer A, Rammensee HG, Opelz G and Terness P (2009) Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? Nat Rev Cancer 9, 445-452 crossref(new window)

Yadav MC, Burudi EM, Alirezaei M et al (2007) IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. Glia 55, 1385-1396 crossref(new window)

Boasso A, Herbeuval JP, Hardy AW, Winkler C and Shearer GM (2005) Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells. Blood 105, 1574-1581 crossref(new window)

Fleckner J, Martensen PM, Tolstrup AB, Kjeldgaard NO and Justesen J (1995) Differential regulation of the human, interferon inducible tryptophanyl-tRNA synthetase by various cytokines in cell lines. Cytokine 7, 70-77 crossref(new window)

Rubin BY, Anderson SL, Xing L, Powell RJ and Tate WP (1991) Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts. J Biol Chem 266, 24245-24248

Doble BW and Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116, 1175-1186 crossref(new window)

Luo J (2009) Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett 273, 194-200 crossref(new window)

Martin M, Rehani K, Jope RS and Michalek SM (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6, 777-784 crossref(new window)

Noh KT, Park YM, Cho SG and Choi EJ (2011) GSK-3beta-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock. Exp Cell Res 317, 1663-1668 crossref(new window)

Baur JA and Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5, 493-506 crossref(new window)

Subramanian L, Youssef S, Bhattacharya S, Kenealey J, Polans AS and van Ginkel PR (2010) Resveratrol: challenges in translation to the clinic--a critical discussion. Clin Cancer Res 16, 5942-5948 crossref(new window)

Kim GY, Cho H, Ahn SC, Oh YH, Lee CM and Park YM (2004) Resveratrol inhibits phenotypic and functional maturation of murine bone marrow-derived dendritic cells. Int Immunopharmacol 4, 245-253 crossref(new window)

Noh KT, Chae SH, Chun SH, Jung ID, Kang HK and Park YM (2013) Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun 431, 348-353 crossref(new window)

Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ and Carbone FR (1994) T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27 crossref(new window)

Yu Z, Theoret MR, Touloukian CE et al (2004) Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance. J Clin Invest 114, 551-559 crossref(new window)

Mellor A (2005) Indoleamine 2,3 dioxygenase and regulation of T cell immunity. Biochem Biophys Res Commun 338, 20-24 crossref(new window)

Zhu L, Ji F, Wang Y et al (2006) Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. J Immunol 177, 8226-8233 crossref(new window)

Prendergast GC (2008) Immune escape as a fundamental trait of cancer: focus on IDO. Oncogene 27, 3889-3900 crossref(new window)

Dorrie J, Gerauer H, Wachter Y and Zunino SJ (2001) Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 61, 4731-4739

Fukui M, Yamabe N and Zhu BT (2010) Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. Eur J Cancer 46, 1882-1891 crossref(new window)

Sun W, Wang W, Kim J et al (2008) Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment. Adv Exp Med Biol 614, 179-186 crossref(new window)

Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S and Takada Y (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24, 2783-2840

Lee SJ, Noh KT, Kang TH et al (2014) The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4. BMB Rep 47, 115-120 crossref(new window)

Lee SJ, Shin SJ, Lee SJ et al (2014) Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response. BMB Rep 47, 512-517 crossref(new window)

Jung ID, Jeong SK, Lee CM et al (2011) Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist. Cancer Res 71, 2858-2870 crossref(new window)