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Anti-septic activity of α-cubebenoate isolated from Schisandra chinensis
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  • Journal title : BMB Reports
  • Volume 48, Issue 6,  2015, pp.336-341
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.6.202
 Title & Authors
Anti-septic activity of α-cubebenoate isolated from Schisandra chinensis
Kook, Minsoo; Lee, Sung Kyun; Kim, Sang Doo; Lee, Ha Young; Hwang, Jae Sam; Choi, Young Whan; Bae, Yoe-Sik;
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Sepsis is a life-threatening, infectious, systemic inflammatory disease. In this study, we investigated the therapeutic effect of α-cubebenoate, a novel compound isolated from Schisandra chinensis against polymicrobial sepsis in a cecal ligation and puncture (CLP) experimental model. Administration of α-cubebenoate strongly enhanced survival in the CLP model. α-cubebenoate administration also markedly blocked CLP-induced lung inflammation and increased bactericidal activity by enhancing phagocytic activity and hydrogen peroxide generation in mouse bone marrow-derived macrophages and neutrophils. Expression of two important inflammatory cytokines, IL-1 and IL-6, was strongly increased in the CLP model, and this was dramatically blocked by α-cubebenoate. Lymphocyte apoptosis and caspase-3 activation, which are associated with immune paralysis during sepsis, were markedly attenuated by α-cubebenoate. Taken together, our findings indicate that α-cubebenoate, a natural compound isolated from Schisandra chinensis, is a powerful potential anti-septic agent. [BMB Reports 2015; 48(6): 336-341]
α-Cubebenoate;Apoptosis;Bactericidal activity;Inflammation;Sepsis;
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