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Stem cell niche as a prognostic factor in leukemia
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  • Journal title : BMB Reports
  • Volume 48, Issue 8,  2015, pp.427-428
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.8.152
 Title & Authors
Stem cell niche as a prognostic factor in leukemia
Lee, Ga-Young; Kim, Jin-A; Oh, Il-Hoan;
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 Abstract
Despite high interests on microenvironmental regulation of leukemic cells, little is known for bone marrow (BM) niche in leukemia patients. Our recent study on BMs of acute myeloid leukemia (AML) patients showed that the mesenchymal stromal cells (MSCs) are altered during leukemic conditions in a clinical course-dependent manner. Leukemic blasts caused reprogramming of transcriptomes in MSCs and remodeling of niche cross-talk, selectively suppressing normal primitive hematopoietic cells while supporting leukemogenesis and chemo-resistance. Notably, differences in BM stromal remodeling were correlated to heterogeneity in subsequent clinical courses of AML, i.e., low numbers of mesenchymal progenitors at initial diagnosis were correlated to complete remission for 5-8 years, and high contents of mesenchymal progenitor or MSCs correlated to early or late relapse, respectively. Thus, stromal remodeling by leukemic cell is an intrinsic part of leukemogenesis that can contribute to the clonal dominance of leukemic cells over normal hematopoietic cells, and can serve as a biomarker for prediction of prognosis. [BMB Reports 2015; 48(8): 427-428]
 Keywords
Niche;Leukemia;Prognostic factor;Biomarker;
 Language
English
 Cited by
1.
Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?, International Journal of Molecular Sciences, 2016, 17, 7, 1009  crossref(new windwow)
2.
The Hematopoietic Niche in Myeloproliferative Neoplasms, Mediators of Inflammation, 2015, 2015, 1  crossref(new windwow)
3.
The Interaction Between Niche and Hematopoietic Stem Cells, Indian Journal of Hematology and Blood Transfusion, 2016, 32, 4, 377  crossref(new windwow)