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Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells
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  • Journal title : BMB Reports
  • Volume 48, Issue 8,  2015, pp.461-466
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.8.216
 Title & Authors
Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells
Eom, Dae-Woon; Lee, Ji Hwan; Kim, Young-Joo; Hwang, Gwi Seo; Kim, Su-Nam; Kwak, Jin Ho; Cheon, Gab Jin; Kim, Ki Hyun; Jang, Hyuk-Jai; Ham, Jungyeob; Kang, Ki Sung; Yamabe, Noriko;
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 Abstract
Epigallocatechin gallate (EGCG) and curcumin are well known to naturally-occurring anticancer agents. The aim of this study was to verify the combined beneficial anticancer effects of curcumin and EGCG on PC3 prostate cancer cells, which are resistant to chemotherapy drugs and apoptosis inducers. EGCG showed weaker inhibitory effect on PC3 cell proliferation than two other prostate cancer cell lines, LNCaP and DU145. Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells. The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin, whereas it was not changed by the treatment with each individual compound. Moreover, treatments of EGCG and curcumin arrested both S and G2/M phases of PC3 cells. These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest. [BMB Reports 2015; 48(8): 461-466]
 Keywords
Curcumin;Epigallocatechin gallate;Growth arrest;Prostate cancer;p21;
 Language
English
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 References
1.
Siegel R, Ward E, Brawley O and Jemal A (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61, 212-236 crossref(new window)

2.
Lange PH and Vessella RL (1998) Mechanisms, hypotheses and questions regarding prostate cancer micrometastases to bone. Cancer Metastasis Rev 17, 331-336 crossref(new window)

3.
Bubendorf L, Schopfer A, Wagner U et al (2000) Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients. Hum Pathol 31, 578-583 crossref(new window)

4.
Roudier MP, Morrissey C, True LD, Higano CS, Vessella RL and Ott SM (2008) Histopathological assessment of prostate cancer bone osteoblastic metastases. J Urol 180, 1154-1160 crossref(new window)

5.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127, 2893-2917 crossref(new window)

6.
Vickers A (2002) Botanical medicines for the treatment of cancer: rationale, overview of current data, and methodological considerations for phase I and II trials. Cancer Invest 20, 1069-1079 crossref(new window)

7.
Shimizu M, Adachi S, Masuda M, Kozawa O and Moriwaki H (2011) Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases. Mol Nutr Food Res 55, 832-843 crossref(new window)

8.
Yang H, Landis-Piwowar K, Chan TH and Dou QP (2011) Green tea polyphenols as proteasome inhibitors: Implication in chemoprevention. Cancer Drug Targets 11, 296-306 crossref(new window)

9.
Sintara K, Thong-Ngam D, Patumraj S and Klaikeaw N (2012) Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats. J Biomed Biotechnol 2012, 1-8 crossref(new window)

10.
Yang CS, Wang X, Lu G and Picinich SC (2009) Cancer prevention by tea: Animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9, 429-439 crossref(new window)

11.
Kim JW, Amin AR and Shin DM (2010) Chemoprevention of head and neck cancer with green tea polyphenols. Cancer Prev Res 3, 900-909 crossref(new window)

12.
Ahmad N, Gupta S and Mukhtar H (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells. Arch Biochem Biophys 376, 338-346 crossref(new window)

13.
Adhami VM, Ahmad N and Mukhtar H (2003) Molecular targets for green tea in prostate cancer prevention. J Nutr 133, 2417-2424

14.
Borska S, Gebarowska E, Wysocka T, Drag-Zalesinska M and Zabel M (2003) Induction of apoptosis by EGCG in selected tumour cell lines in vitro. Folia Histochem Cytobiol 41, 229-232

15.
Ahmad KA, Harris NH, Johnson AD, Lindvall HC, Wang G and Ahmed K (2007) Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells. Mol Cancer Ther 6, 1006-1012 crossref(new window)

16.
Chung LY, Cheung TC, Kong SK et al (2001) Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. Life Sci 68, 1207-1214 crossref(new window)

17.
Hastak K, Agarwal MK, Mukhtar H and Agarwal ML (2005) Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate. FASEB J 19, 789-791

18.
Kuttan G, Kumar KB, Guruvayoorappan C and Kuttan R (2007) Antitumor, anti-invasion, and antimetastatic effects of curcumin. Adv Exp Med Biol 595, 173-184 crossref(new window)

19.
Kunnumakkara AB, Anand P and Aggarwal BB (2008) Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269, 199-225 crossref(new window)

20.
Zhang X, Chen LX, Ouyang L, Cheng Y and Liu B (2012) Plant natural compounds: Targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif 45, 466-476 crossref(new window)

21.
Shehzad A, Wahid F and Lee YS (2010) Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm 343, 489-499 crossref(new window)

22.
Mukhtar H and Ahmad N (1999) Cancer chemoprevention: future holds in multiple agents. Toxicol Appl Pharmacol 158, 207-210 crossref(new window)

23.
McCarty MF (2004) Targeting multiple signaling pathways as a strategy for managing prostate cancer: multifocal signal modulation therapy. Integr Cancer Ther 3, 349-380 crossref(new window)

24.
Banerjee S, Zhang Y, Ali S et al (2005) Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 65, 9064-9072 crossref(new window)

25.
Khor TO, Keum YS, Lin W et al (2006) Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res 66, 613-621 crossref(new window)

26.
Narayanan BA, Narayanan NK, Pttman B and Reddy BS (2006) Adenocarcina of the mouse prostate growth inhibition by celecoxib: downregulation of transcription factors involved in COX-2 inhibition. Prostate 66, 257-265 crossref(new window)

27.
Adhami VM, Malik A, Zaman N et al (2007) Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin Cancer Res 13, 1611-1619 crossref(new window)

28.
Chou TC (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58, 621-681 crossref(new window)

29.
Suganuma M, Saha A and Fujiki H (2011) New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci 102, 317-323 crossref(new window)

30.
Stone A, Sutherland RL and Musgrove EA (2012) Inhibitors of cell cycle kinases: Recent advances and future prospects as cancer therapeutics. Crit Rev 17, 175-198

31.
Chauhan DP (2002) Chemotherapeutic potential of curcumin for colorectal cancer. Curr Pharm 8, 1695-1706 crossref(new window)

32.
Shankar S, Suthakar G and Srivastava RK (2007) Epigallocatechin- 3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer. Front Biosci 12, 5039-5051 crossref(new window)

33.
Saha A, Kuzuhara T, Echigo N, Suganuma M and Fujiki H (2010) New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. Cancer Prev Res 3, 953-962 crossref(new window)

34.
Kim S, Lee MJ, Hong J et al (2000) Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols. Nutr Cancer 37, 41-48 crossref(new window)

35.
Somers-Edgar TJ, Scandlyn MJ, Stuart EC, le Nedelec MJ, Valentine SP and Rosengren RJ (2008) The combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo. Int J Cancer 122, 1966-1971 crossref(new window)