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Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo
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  • Journal title : BMB Reports
  • Volume 48, Issue 9,  2015, pp.519-524
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.9.017
 Title & Authors
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo
Ku, Sae-Kwang; Bae, Jong-Sup;
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Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, in this study, we attempted to determine whether three structurally related polyphenols found in the Chinese herb Huang Qui, namely baicalin, baicalein, and wogonin, can suppress vascular inflammatory processes induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS) and activation of nuclear factor (NF)-κB. Remarkably, all of the above mentioned vascular inflammatory effects of HG were attenuated by pretreatment with baicalin, baicalein, and wogonin. Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications, therefore, our results suggest that baicalin, baicalein, and wogonin may have significant therapeutic benefits against diabetic complications and atherosclerosis. [BMB Reports 2015; 48(9): 519-524]
Baicalein;Baicalin;Diabetes mellitus;Wogonin;High glucose;
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