JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : BMB Reports
  • Volume 48, Issue 9,  2015, pp.519-524
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2015.48.9.017
 Title & Authors
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo
Ku, Sae-Kwang; Bae, Jong-Sup;
  PDF(new window)
 Abstract
Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, in this study, we attempted to determine whether three structurally related polyphenols found in the Chinese herb Huang Qui, namely baicalin, baicalein, and wogonin, can suppress vascular inflammatory processes induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS) and activation of nuclear factor (NF)-κB. Remarkably, all of the above mentioned vascular inflammatory effects of HG were attenuated by pretreatment with baicalin, baicalein, and wogonin. Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications, therefore, our results suggest that baicalin, baicalein, and wogonin may have significant therapeutic benefits against diabetic complications and atherosclerosis. [BMB Reports 2015; 48(9): 519-524]
 Keywords
Baicalein;Baicalin;Diabetes mellitus;Wogonin;High glucose;
 Language
English
 Cited by
1.
Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion, The Korean Journal of Physiology & Pharmacology, 2016, 20, 5, 515  crossref(new windwow)
2.
Roles of Chinese herbal medicines in ischemic heart diseases (IHD) by regulating oxidative stress, International Journal of Cardiology, 2016, 220, 314  crossref(new windwow)
3.
Reversibility of endothelial dysfunction in diabetes: role of polyphenols, British Journal of Nutrition, 2016, 116, 02, 223  crossref(new windwow)
4.
Suppressive effects of three diketopiperazines from marine-derived bacteria on TGFBIp-mediated septic responses in human endothelial cells and mice, Archives of Pharmacal Research, 2016, 39, 6, 843  crossref(new windwow)
5.
Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties, Molecular and Cellular Endocrinology, 2016, 428, 101  crossref(new windwow)
6.
Antidiabetic properties of dietary flavonoids: a cellular mechanism review, Nutrition & Metabolism, 2015, 12, 1  crossref(new windwow)
7.
Suppressive effects of polyozellin on TGFBIp-mediated septic responses in human endothelial cells and mice, Nutrition Research, 2016, 36, 4, 380  crossref(new windwow)
8.
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids, International Journal of Molecular Sciences, 2016, 17, 4, 569  crossref(new windwow)
 References
1.
Whiting DR, Guariguata L, Weil C and Shaw J (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94, 311-321 crossref(new window)

2.
Grundy SM, Benjamin IJ, Burke GL et al (1999) Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100, 1134-1146 crossref(new window)

3.
Thomas JE and Foody JM (2007) The pathophysiology of cardiovascular disease in diabetes mellitus and the future of therapy. J Cardiometab Syndr 2, 108-113 crossref(new window)

4.
Roglic G, Unwin N, Bennett PH et al (2005) The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care 28, 2130-2135 crossref(new window)

5.
Rubino F and Gagner M (2002) Potential of surgery for curing type 2 diabetes mellitus. Ann Surg 236, 554-559 crossref(new window)

6.
Li GQ, Kam A, Wong KH et al (2012) Herbal medicines for the management of diabetes. Adv Exp Med Biol 771, 396-413

7.
Day C (1998) Traditional plant treatments for diabetes mellitus: pharmaceutical foods. Br J Nutr 80, 5-6 crossref(new window)

8.
Kubo M, Asano T, Shiomoto H and Matsuda H (1994) Studies on rehmanniae radix. I. Effect of 50% ethanolic extract from steamed and dried rehmanniae radix on hemorheology in arthritic and thrombosic rats. Biol Pharm Bull 17, 1282-1286 crossref(new window)

9.
Kubo M, Matsuda H, Tanaka M et al (1984) Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix. Chem Pharm Bull (Tokyo) 32, 2724-2729 crossref(new window)

10.
Chen YC, Shen SC, Chen LG, Lee TJ and Yang LL (2001) Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol 61, 1417-1427 crossref(new window)

11.
Chiu JH, Lay IS, Su MY et al (2002) Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line. Planta Med 68, 1036-1039 crossref(new window)

12.
Laakso M (1999) Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 48, 937-942 crossref(new window)

13.
Kannel WB and McGee DL (1979) Diabetes and cardiovascular disease. The Framingham study. JAMA 241, 2035-2038 crossref(new window)

14.
Nannipieri M, Rizzo L, Rapuano A, Pilo A, Penno G and Navalesi R (1995) Increased transcapillary escape rate of albumin in microalbuminuric type II diabetic patients. Diabetes Care 18, 1-9 crossref(new window)

15.
Wardle EN (1994) Vascular permeability in diabetics and implications for therapy. Diabetes Res Clin Pract 23, 135-139 crossref(new window)

16.
Tooke JE (1995) Microvascular function in human diabetes. A physiological perspective. Diabetes 44, 721-726 crossref(new window)

17.
Gerrity RG (1981) The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol 103, 181-190

18.
Esposito C, Fasoli G, Plati AR et al (2001) Long-term exposure to high glucose up-regulates VCAM-induced endo- thelial cell adhesiveness to PBMC. Kidney Int 59, 1842-1849 crossref(new window)

19.
Hamuro M, Polan J, Natarajan M and Mohan S (2002) High glucose induced nuclear factor kappa B mediated inhibition of endothelial cell migration. Atherosclerosis 162, 277-287 crossref(new window)

20.
Morigi M, Angioletti S, Imberti B et al (1998) Leukocyteendothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. J Clin Invest 101, 1905-1915 crossref(new window)

21.
Lopes-Virella MF and Virella G (1992) Immune mechanisms of atherosclerosis in diabetes mellitus. Diabetes 41 Suppl 2, 86-91 crossref(new window)

22.
Bae JS (2012) Role of high mobility group box 1 in inflammatory disease: Focus on sepsis. Arch Pharm Res 35, 1511-1523 crossref(new window)

23.
Kado S, Wakatsuki T, Yamamoto M and Nagata N (2001) Expression of intercellular adhesion molecule-1 induced by high glucose concentrations in human aortic endothelial cells. Life Sci 68, 727-737 crossref(new window)

24.
Hansson GK and Libby P (2006) The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 6, 508-519 crossref(new window)

25.
Boisvert WA (2004) Modulation of atherogenesis by chemokines. Trends Cardiovasc Med 14, 161-165 crossref(new window)

26.
Inoguchi T, Li P, Umeda F et al (2000) High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49, 1939-1945 crossref(new window)

27.
Dunlop M (2000) Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int Suppl 77, S3-12 crossref(new window)

28.
Han HJ, Lee YJ, Park SH, Lee JH and Taub M (2005) High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells. Am J Physiol Renal Physiol 288, F988-996 crossref(new window)

29.
Rimbach G, Valacchi G, Canali R and Virgili F (2000) Macrophages stimulated with IFN-gamma activate NFkappa B and induce MCP-1 gene expression in primary human endothelial cells. Mol Cell Biol Res Commun 3, 238-242 crossref(new window)

30.
Uemura S, Matsushita H, Li W et al (2001) Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circ Res 88, 1291-1298 crossref(new window)