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Emerging roles of exosomes in cancer invasion and metastasis
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  • Journal title : BMB Reports
  • Volume 49, Issue 1,  2016, pp.18-25
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2016.49.1.239
 Title & Authors
Emerging roles of exosomes in cancer invasion and metastasis
Soung, Young Hwa; Nguyen, Thalia; Cao, Hans; Lee, Janet; Chung, Jun;
  PDF(new window)
 Abstract
Recent evidence has indicated that nano-sized vesicles called "exosomes" mediate the interaction between cancer cells and their microenvironment and play a critical role in the development of cancers. Exosomes contain cargo consisting of proteins, lipids, mRNAs, and microRNAs that can be delivered to different types of cells in nascent as well as distant locations. Cancer cell-derived exosomes (CCEs) have been identified in body fluids such as urine, plasma, and saliva from patients with cancer. Although their content depends on tumor type and stage, CCEs merit consideration as prognostic and diagnostic markers, as vehicles for drug delivery, and as potential therapeutic targets because they could transport various oncogenic elements. In this review, we summarize recent advances regarding the role of CCEs in cancer invasion and metastasis, as well as its potential clinical applications. [BMB Reports 2016; 49(1): 18-25]
 Keywords
Exosomes;Invasion;Metastasis;Drug resistance;Biomarkers;Therapeutic application;
 Language
English
 Cited by
1.
Mesenchymal Stem Cell-Derived Exosomes: New Opportunity in Cell-Free Therapy, Advanced Pharmaceutical Bulletin, 2016, 6, 3, 293  crossref(new windwow)
2.
Exosome cargo reflects TGF-β1-mediated epithelial-to-mesenchymal transition (EMT) status in A549 human lung adenocarcinoma cells, Biochemical and Biophysical Research Communications, 2016, 478, 2, 643  crossref(new windwow)
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