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Emerging roles of exosomes in cancer invasion and metastasis
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  • Journal title : BMB Reports
  • Volume 49, Issue 1,  2016, pp.18-25
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2016.49.1.239
 Title & Authors
Emerging roles of exosomes in cancer invasion and metastasis
Soung, Young Hwa; Nguyen, Thalia; Cao, Hans; Lee, Janet; Chung, Jun;
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Recent evidence has indicated that nano-sized vesicles called "exosomes" mediate the interaction between cancer cells and their microenvironment and play a critical role in the development of cancers. Exosomes contain cargo consisting of proteins, lipids, mRNAs, and microRNAs that can be delivered to different types of cells in nascent as well as distant locations. Cancer cell-derived exosomes (CCEs) have been identified in body fluids such as urine, plasma, and saliva from patients with cancer. Although their content depends on tumor type and stage, CCEs merit consideration as prognostic and diagnostic markers, as vehicles for drug delivery, and as potential therapeutic targets because they could transport various oncogenic elements. In this review, we summarize recent advances regarding the role of CCEs in cancer invasion and metastasis, as well as its potential clinical applications. [BMB Reports 2016; 49(1): 18-25]
Exosomes;Invasion;Metastasis;Drug resistance;Biomarkers;Therapeutic application;
 Cited by
각질형성세포 유래 엑소좀이 피부각질형성세포의 증식과 이주에 미치는 영향,김도윤;유호진;황대일;장상희;이환명;

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