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Structure biology of selective autophagy receptors
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  • Journal title : BMB Reports
  • Volume 49, Issue 2,  2016, pp.73-80
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2016.49.2.265
 Title & Authors
Structure biology of selective autophagy receptors
Kim, Byeong-Won; Kwon, Do Hoon; Song, Hyun Kyu;
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 Abstract
Autophagy is a process tightly regulated by various autophagy-related proteins. It is generally classified into non-selective and selective autophagy. Whereas non-selective autophagy is triggered when the cell is under starvation, selective autophagy is involved in eliminating dysfunctional organelles, misfolded and/or ubiquitylated proteins, and intracellular pathogens. These components are recognized by autophagy receptors and delivered to phagophores. Several selective autophagy receptors have been identified and characterized. They usually have some common domains, such as motif, a specific cargo interacting (ubiquitin-dependent or ubiquitin-independent) domain. Recently, structural data of these autophagy receptors has been described, which provides an insight of their function in the selective autophagic process. In this review, we summarize the most up-to-date findings about the structure-function of autophagy receptors that regulates selective autophagy.
 Keywords
Autophagy;LIR motif;Receptor;Selective autophagy;Ubiquitin binding domain;
 Language
English
 Cited by
1.
The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane, Autophagy, 2016, 00  crossref(new windwow)
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