Advanced SearchSearch Tips
Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : BMB Reports
  • Volume 49, Issue 5,  2016, pp.276-281
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2016.49.5.241
 Title & Authors
Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
Kim, Seung-Jae; Cha, Ji-Young; Kang, Hye Suk; Lee, Jae-Ho; Lee, Ji Yoon; Park, Jae-Hyung; Bae, Jae-Hoon; Song, Dae-Kyu; Im, Seung-Soon;
  PDF(new window)
Corosolic acid (CA), a triterpenoid compound isolated from Lagerstroemia speciosa L. (Banaba) leaves, exerts anti-inflammatory effects by regulating phosphorylation of interleukin receptor- associated kinase (IRAK)-2 via the NF-κB cascade. However, the protective effect of CA against endotoxic shock has not been reported. LPS (200 ng/mL, 30 min) induced phosphorylation of IRAK-1 and treatment with CA (10 μM) significantly attenuated this effect. In addition, CA also reduced protein levels of NLRP3 and ASC which are the main components of the inflammasome in BMDMs. LPS-induced inflammasome assembly through activation of IRAK-1 was down-regulated by CA challenge. Treatment with Bay11-7082, an inhibitor of IκB-α, had no effect on CA-mediated inhibition of IRAK-1 activation, indicating that CA-mediated attenuation of IRAK-1 phosphorylation was independent of NF-κB signaling. These results demonstrate that CA ameliorates acute inflammation in mouse BMDMs and CA may be useful as a pharmacological agent to prevent acute inflammation.
Acute inflammation;Corosolic acid;Inflammasome;IRAK-1;Macrophages;
 Cited by
Kushner I (1982) The phenomenon of the acute phase response. Ann N Y Acad Sci 389, 39-48 crossref(new window)

Sherwood ER and Toliver-Kinsky T (2004) Mechanisms of the inflammatory response. Best Pract Res Clin Anaesthesiol 18, 385-405 crossref(new window)

Kim KK, Jin SH and Lee BJ (2013) Herpes virus entry mediator signaling in the brain is imperative in acute inflammation-induced anorexia and body weight loss. Endocrinol Metab (Seoul) 28, 214-220 crossref(new window)

Rock KL and Kono H (2008) The inflammatory response to cell death. Annu Rev Pathol 3, 99-126 crossref(new window)

Akira S (2001) Toll-like receptors and innate immunity. Adv Immunol 78, 1-56 crossref(new window)

Medzhitov R and Janeway C Jr (2000) Innate immune recognition: mechanisms and pathways. Immunol Rev 173, 89-97 crossref(new window)

Chen G, Shaw MH, Kim YG and Nunez G (2009) NODlike receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol 4, 365-398 crossref(new window)

Franchi L, Munoz-Planillo R and Nunez G (2012) Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13, 325-332 crossref(new window)

Franchi L, Eigenbrod T, Munoz-Planillo R and Nunez G (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 10, 241-247 crossref(new window)

Lin KM, Hu W, Troutman TD et al (2014) IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci U S A 111, 775-780 crossref(new window)

Trofimova M, Sprenkle AB, Green M, Sturgill TW, Goebl MG and Harrington MA (1996) Developmental and tissue-specific expression of mouse pelle-like protein kinase. J Biol Chem 271, 17609-17612 crossref(new window)

Uematsu S, Sato S, Yamamoto M et al (2005) Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med 201, 915-923 crossref(new window)

Flannery S and Bowie AG (2010) The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling. Biochem Pharmacol 80, 1981-1991 crossref(new window)

Cao Z, Henzel WJ and Gao X (1996) IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128-1131 crossref(new window)

Pikarsky E, Porat RM, Stein I et al (2004) NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431, 461-466 crossref(new window)

Karin M, Cao Y, Greten FR and Li ZW (2002) NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2, 301-310 crossref(new window)

Chen H, Yang J, Zhang Q, Chen LH and Wang Q (2012) Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-kappaB signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. Circ J 76, 995-1003 crossref(new window)

Bai N, He K, Roller M et al (2008) Active compounds from Lagerstroemia speciosa, insulin-like glucose uptake-stimulatory/inhibitory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Agric Food Chem 56, 11668-11674 crossref(new window)

Priya TT, Sabu MC and Jolly CI (2008) Free radical scavenging and anti-inflammatory properties of Lagerstroemia speciosa (L). Inflammopharmacology 16, 182-187 crossref(new window)

Aguirre MC, Delporte C, Backhouse N et al (2006) Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorg Med Chem 14, 5673-5677 crossref(new window)

Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM and Passwater R (2003) Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol 87, 115-117 crossref(new window)

Sato J, Goto K, Nanjo F, Kawai S and Murata K (2000) Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola. J Biosci Bioeng 90, 442-446 crossref(new window)

Choi HJ, Bae EY, Song JH, Baek SH and Kwon DH (2010) Inhibitory effects of orobol 7-O-D-glucoside from banaba (Lagerstroemia speciosa L.) on human rhinoviruses replication. Lett Appl Microbiol 51, 1-5

Lee MS, Cha EY, Thuong PT, Kim JY, Ahn MS and Sul JY (2010) Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells. Biol Pharm Bull 33, 931-937 crossref(new window)

Shim KS, Lee SU, Ryu SY, Min YK and Kim SH (2009) Corosolic acid stimulates osteoblast differentiation by activating transcription factors and MAP kinases. Phytother Res 23, 1754-1758 crossref(new window)

Bauernfeind F, Bartok E, Rieger A, Franchi L, Nunez G and Hornung V (2011) Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol 187, 613-617 crossref(new window)

Means TK, Golenbock DT and Fenton MJ (2000) The biology of Toll-like receptors. Cytokine Growth Factor Rev 11, 219-232 crossref(new window)

Diano S (2013) Role of reactive oxygen species in hypothalamic regulation of energy metabolism. Endocrinol Metab (Seoul) 28, 3-5 crossref(new window)

Lin SC, Lo YC and Wu H (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 465, 885-890 crossref(new window)

Pauls E, Nanda SK, Smith H, Toth R, Arthur JS and Cohen P (2013) Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice. J Immunol 191, 2717-2730 crossref(new window)

Li S, Strelow A, Fontana EJ and Wesche H (2002) IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A 99, 5567-5572 crossref(new window)

Gilchrist M, Thorsson V, Li B et al (2006) Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441, 173-178 crossref(new window)

Im SS, Kim MY, Kwon SK et al (2011) Peroxisome proliferator-activated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice. J Biol Chem 286, 1157-1164 crossref(new window)

Ayala A, Perrin MM, Kisala JM, Ertel W and Chaudry IH (1992) Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor). Circ Shock 36, 191-199