Advanced SearchSearch Tips
A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : BMB Reports
  • Volume 49, Issue 5,  2016, pp.293-296
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2016.49.5.023
 Title & Authors
A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model
Kim, Hyuk Soon; Jang, Jong-Hwa; Lee, Min Bum; Jung, In Duk; Park, Yeong-Min; Kim, Young Mi; Choi, Wahn Soo;
  PDF(new window)
The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that the ratio of IL-10-producing cells was significantly increased in lineage negative (i.e., not T, B, or leukocyte cell lineages) cells than in lineage positive cells in lymphoid and peripheral tissues. We further observed that IL-10-producing innate lymphoid cells (ILCs), here called firstly ILC10, were increased in number in oxazolone-induced contact hypersensitivity (CHS) mice. In detail, IL-10-producing lineage negative cells were elevated in the axillary, inguinal lymph node, and ear tissues of CHS mice. Notably, the cells expressed classical ILC marker proteins such as CD45, CD127, and Sca-1. Altogether, our findings suggest for the first time that ILC10s are present in various physiological settings and could be involved in numerous immune responses as regulatory cells.
Contact hypersensitivity;ILC10;Innate lymphoid cells (ILCs);Interleukin-10;regulatory ILCs;
 Cited by
Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases, Nature Reviews Rheumatology, 2017, 13, 3, 164  crossref(new windwow)
Type two innate lymphoid cells: the Janus cells in health and disease, Immunological Reviews, 2017, 278, 1, 192  crossref(new windwow)
Koyasu S and Moro K (2012) Role of innate lymphocytes in infection and inflammation. Front Immunol 3, 101 crossref(new window)

Spits H and Cupedo T (2012) Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol 30, 647-675 crossref(new window)

Diefenbach A, Colonna M, and Koyasu S (2014) Development, differentiation, and diversity of innate lymphoid cells. Immunity 41, 354-365 crossref(new window)

Spits H, Artis D, Colonna M et al (2013) Innate lymphoid cells-a proposal for uniform nomenclature. Nat Rev Immunol 13, 145-149 crossref(new window)

Fuchs A, Vermi W, Lee JS et al (2013) Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity 38, 769-781 crossref(new window)

Neill DR, Wong SH, Bellosi A et al (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370 crossref(new window)

Klein Wolterink RG, Serafini N, van Nimwegen M et al (2013) Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc Natl Acad Sci U S A 110, 10240-10245 crossref(new window)

Yagi R, Zhong C, Northrup DL et al (2014) The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells. Immunity 40, 378-388 crossref(new window)

Cupedo T, Crellin NK, Papazian N et al (2009) Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol 10, 66-74 crossref(new window)

Couper KN, Blount DG and Riley EM (2008) IL-10: the master regulator of immunity to infection. J Immunol 180, 5771-5777 crossref(new window)

Moore KW, de Waal Malefyt R, Coffman RL and O’Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19, 683-765 crossref(new window)

Saraiva M and O’Garra A (2010) The regulation of IL-10 production by immune cells. Nat Rev Immunol 10, 170-181 crossref(new window)

O'Garra A, Vieira PL, Vieira P and Goldfeld AE (2004) IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. J Clin Invest 114, 1372-1378 crossref(new window)

Chaudhry A, Samstein RM, Treuting P et al (2011) Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 34, 566-578 crossref(new window)

Noh J, Noh G, Lee SJ et al (2012) Tolerogenic effects of interferon-gamma with induction of allergen-specific interleukin-10-producing regulatory B cell (Br1) changes in non-IgE-mediated food allergy. Cell Immunol 273, 140-149 crossref(new window)

Kim HS, Lee JH, Han HD et al (2015) Autocrine stimulation of IL-10 is critical to the enrichment of IL-10-producing CD40(hi)CD5(+) regulatory B cells in vitro and in vivo. BMB Rep 48, 54-59 crossref(new window)

Lee SJ, Shin SJ, Lee SJ et al (2014) Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response. BMB Rep 47, 512-517 crossref(new window)

Yanaba K, Bouaziz JD, Haas KM et al (2008) A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28, 639-650 crossref(new window)

DiLillo DJ, Matsushita T and Tedder TF (2010) B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci 1183, 38-57 crossref(new window)

Kim HS, Kim AR, Kim DK et al (2015) Interleukin-10-producing CD5+ B cells inhibit mast cells during immunoglobulin E-mediated allergic responses. Sci Signal 8, ra28 crossref(new window)

Kim AR, Kim HS, Kim DK et al (2016) Mesenteric IL-10-producing CD5(+) regulatory B cells suppress cow's milk casein-induced allergic responses in mice. Sci Rep 6, 19685 crossref(new window)

Gregori S, Tomasoni D, Pacciani V et al (2010) Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 116, 935-944 crossref(new window)

Zhang X, Majlessi L, Deriaud E et al (2009) Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity 31, 761-771 crossref(new window)

Robinette ML, Fuchs A, Cortez VS et al (2015) Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol 16, 306-317 crossref(new window)

Wang B, Fujisawa H, Zhuang L et al (2000) CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity. J Immunol 165, 6783-6790 crossref(new window)