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Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis
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  • Journal title : BMB Reports
  • Volume 49, Issue 7,  2016, pp.394-399
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2016.49.7.011
 Title & Authors
Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis
Liao, Zheng-qiang; Ye, Ming; Yu, Pei-gen; Xiao, Chun; Lin, Feng-yun;
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 Abstract
Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulated in glioma tissues, as in comparison to in normal tissues. These up-regulation phenomena were also observed in glioma U251 and U87 cells. It was demonstrated that Gli1 positively regulated the AQP1 expression. By luciferase reporter gene and ChIP assay, we observed that this modulation process was realized by combination of Gli1 with AQP1 promotor. In addition, knock down of Gli1 by siRNA interference reduced the viability of glioma cells as well as suppressed cell metastasis. Also, the inhibitory effects of cell survival by silenced Gli1 were abrogated by AQP1 overexpression. In summary, glioma cell survival is a regulatory process and can be mediated by Gli1-AQP1 pathway.
 Keywords
Invasion;Migration;U251;U87;
 Language
English
 Cited by
 References
1.
Cordier N, Delingette H and Ayache N (2016) A patch-based approach for the segmentation of pathologies: Application to glioma labelling. IEEE Trans Med Imaging 35, 1066-1076 crossref(new window)

2.
Molinaro AM, Wrensch MR, Jenkins RB and Eckel-Passow JE (2016) Statistical considerations on prognostic models for glioma. Neuro Oncol 18, 609-623 crossref(new window)

3.
Roder C, Bisdas S, Ebner FH et al (2014) Maximizing the extent of resection and survival benefit of patients in glioblastoma surgery: high-field iMRI versus conventional and 5-ALA-assisted surgery. Eur J Surg Oncol 40, 297-304 crossref(new window)

4.
Quail DF and Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19, 1423-1437 crossref(new window)

5.
Hambardzumyan D, Gutmann DH and Kettenmann H (2015) The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci 19, 20-27 crossref(new window)

6.
Liu X, Wang X, Du W et al (2014) Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis. Oncotarget 5, 11681-11694 crossref(new window)

7.
Du WZ, Feng Y, Wang XF et al (2013) Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo. CNS Neurosci Ther 19, 926-936 crossref(new window)

8.
Ji H, Miao J, Zhang X et al (2012) Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke. Neurosci Lett 506, 1-6 crossref(new window)

9.
Wang LW, Lin H, Lu Y, Xia W, Gao J and Li ZS (2014) Sonic hedgehog expression in a rat model of chronic pancreatitis. World J Gastroenterol 20, 4712-4717 crossref(new window)

10.
Wick W and Kuker W (2004) Brain edema in neurooncology: radiological assessment and management. Onkologie 27, 261-266

11.
El Hindy N, Rump K, Lambertz N et al (2013) The functional Aquaporin 1 -783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme. J Surg Oncol 108, 492-498 crossref(new window)

12.
Deb P, Pal S, Dutta V, Boruah D, Chandran VM and Bhatoe HS (2012) Correlation of expression pattern of aquaporin-1 in primary central nervous system tumors with tumor type, grade, proliferation, microvessel density, contrast-enhancement and perilesional edema. J Cancer Res Ther 8, 571-577 crossref(new window)

13.
Qiu B, Li X, Sun X et al (2014) Overexpression of aquaporin1 aggravates hippocampal damage in mouse traumatic brain injury models. Mol Med Rep 9, 916-922

14.
Park M, Song C, Yoon H and Choi KH (2016) Double Blockade of Glioma Cell Proliferation and Migration by Temozolomide Conjugated with NPPB, a Chloride Channel Blocker. ACS Chem Neurosci 7, 275-285 crossref(new window)

15.
Carpenter RL, Paw I, Zhu H et al (2015) The gain-offunction GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Oncotarget 6, 22653-22665 crossref(new window)

16.
Lampichler K, Ferrer P, Vila G et al (2015) The role of proto-oncogene GLI1 in pituitary adenoma formation and cell survival regulation. Endocr Relat Cancer 22, 793-803 crossref(new window)

17.
Singh RR, Kunkalla K, Qu C et al (2011) ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Oncogene 30, 4874-4886 crossref(new window)

18.
Liu S, Duan X, Xu L et al (2016) Nuclear Gli1 expression is associated with pathological complete response and event-free survival in HER2-positive breast cancer treated with trastuzumab-based neoadjuvant therapy. Tumour Biol 37, 4873-4881 crossref(new window)

19.
Morrissey JJ, Mellnick VM, Luo J et al (2015) Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study. JAMA Oncol 1, 204-212 crossref(new window)

20.
Wei X and Dong J (2015) Aquaporin 1 promotes the proliferation and migration of lung cancer cell in vitro. Oncol Rep 34, 1440-1448

21.
Bora-Singhal N, Perumal D, Nguyen J and Chellappan S (2015) Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer. Neoplasia 17, 538-551 crossref(new window)