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Amino-β-cyclodextrin Complex Assisted Ionization for Labile Sesamins and their Ion-mobility Separation in ESI Q-TOF MS
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  • Journal title : Mass Spectrometry Letters
  • Volume 6, Issue 1,  2015, pp.17-20
  • Publisher : Korean Society Mass Spectrometry
  • DOI : 10.5478/MSL.2015.6.1.17
 Title & Authors
Amino-β-cyclodextrin Complex Assisted Ionization for Labile Sesamins and their Ion-mobility Separation in ESI Q-TOF MS
Sugahara, Kohtaro; Horikawa, Manabu; Yamagaki, Tohru;
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 Abstract
Sesamin, one of the lignans in sesame seed, was a labile compound in MS and it was reported that the protonated molecule of sesamin decomposed easily in ES ionization process and it cannot be detected (G. Yan, et al., Rapid Commun Mass Spectrom. 2007, 21, 3613-3620). To protect labile compounds, an amino-cyclodextrin (NCyD) was added to the sample to promote the host-guest interaction complex in ESI-MS. As a result, sesamin was ionized as the NCyD-sesamin-NCyD (1:2) complex without undesired decomposition, suggesting that the amino-CyDs assist the ionization of the labile molecules capped with CyDs by host-guest interaction and these compounds were ionized without their decomposition, those are like amino-CyD complex-assisted ionization. The amino-CyD complexes of sesamin and sesamolin were also analyzed by their ion-mobility MS.
 Keywords
cyclodextrin;host-guest interaction;ionization assist;
 Language
English
 Cited by
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