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Sample Preparation for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
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  • Journal title : Mass Spectrometry Letters
  • Volume 6, Issue 2,  2015, pp.27-30
  • Publisher : Korean Society Mass Spectrometry
  • DOI : 10.5478/MSL.2015.6.2.27
 Title & Authors
Sample Preparation for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Kim, Jeongkwon;
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 Abstract
This article reviews the fundamentals of sample preparation used in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). MALDI is a soft ionization method used to generate analyte ions in their intact forms, which are then detected in MS analysis. MALDI-MS boasts fast analysis times and easy-to-use operation. The disadvantages of MALDI-MS include the occurrence of matrix-associated peaks and inhomogeneous distribution of analyte within the matrix. To overcome the disadvantages of MALDI-MS, various efforts have been directed such as using different matrices, novel matrix systems, various additives, and different sample preparation methods. These various efforts will be discussed in detail. This article will benefit those who would like to obtain basic knowledge of MALDI sample preparation and those who would like to use MALDI-MS in their chemical analyses.
 Keywords
MALDI-MS;2,5-dihydrobenzoic acid;α-cyano-4-hydroxycinnamic acid;sinapic acid;additives;
 Language
English
 Cited by
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A Novel “Freeze Vacuum Drying” Crystallization Method Toward Quantitative MALDI-MS, Bulletin of the Korean Chemical Society, 2017, 38, 1, 133  crossref(new windwow)
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Rapid Surface Heating Promotes Laser Desorption Ionization of Thermally Labile Molecules from Surfaces, Mass Spectrometry Letters, 2016, 7, 4, 91  crossref(new windwow)
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Bacterial analysis by laser desorption ionization mass spectrometry on amorphous silicon, Biointerphases, 2016, 11, 4, 041008  crossref(new windwow)
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Matrix Additives in MALDI-TOF MS Analysis of Glycans, Bulletin of the Korean Chemical Society, 2016, 37, 1, 105  crossref(new windwow)
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