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Soft Ionization of Metallo-Mefenamic Using Electrospray Ionization Mass Spectrometry
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  • Journal title : Mass Spectrometry Letters
  • Volume 6, Issue 2,  2015, pp.43-47
  • Publisher : Korean Society Mass Spectrometry
  • DOI : 10.5478/MSL.2015.6.2.43
 Title & Authors
Soft Ionization of Metallo-Mefenamic Using Electrospray Ionization Mass Spectrometry
Abdelhamid, Hani Nasser; Wu, Hui-Fen;
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 Abstract
Detection of mefenamic acid (M, non-steroidal anti-inflammatory drug, NSAIDs) and its metallodrug was investigated using electrospray ionization mass spectrometry (ESI-MS) and fluorescence spectroscopy. ESI-MS data (500 µL, 1×10-3 M) revealed high detection sensitivity for the drug and metallodrug. ESI-MS spectra revealed peaks at 242, 580, and 777 Da corresponding to [M+H]+, [63Cu(M-H)2(H2O)2+H]+, and [56Fe(M-H)3+H]+, respectively. The metal:mefenamic ratios of ESIMS spectra are in complete agreement with the fluorescence spectroscopy results (1:2 for Cu(II) and 1:3 for Fe(III)). ESI is a soft ionization technique that can be used on labile metallo-mefenamic acids and is promising for the detection of these species in environmental samples and biological fluids.
 Keywords
Mefenamic Acid;Metallodrug;ESI-MS;Fluorescence spectroscopy;
 Language
English
 Cited by
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Surface tuning laser desorption/ionization mass spectrometry (STLDI-MS) for the analysis of small molecules using quantum dots, Analytical and Bioanalytical Chemistry, 2017, 409, 21, 4943  crossref(new windwow)
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