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Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
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  • Journal title : Mass Spectrometry Letters
  • Volume 6, Issue 2,  2015, pp.48-51
  • Publisher : Korean Society Mass Spectrometry
  • DOI : 10.5478/MSL.2015.6.2.48
 Title & Authors
Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
Rehman, Shaheed Ur; Kim, n Sook; Choi, Min Sun; Luo, Zengwei; Yao, Guangming; Xue, Yongbo; Zhang, Yonghui; Yoo, Hye Hyun;
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Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
kinsenoside;stability;liver microsomes;
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