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UHPLC-ESI-qTOF-MS Analysis of Cyclopeptide Alkaloids in the Seeds of Ziziphus jujuba var. spinosa
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  • Journal title : Mass Spectrometry Letters
  • Volume 7, Issue 2,  2016, pp.45-49
  • Publisher : Korean Society Mass Spectrometry
  • DOI : 10.5478/MSL.2016.7.2.45
 Title & Authors
UHPLC-ESI-qTOF-MS Analysis of Cyclopeptide Alkaloids in the Seeds of Ziziphus jujuba var. spinosa
Kang, Kyo Bin; Jang, Dae Sik; Kim, Jinwoong; Sung, Sang Hyun;
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 Abstract
An UHPLC-ESI-qTOF-MS analytical method was developed for cyclopeptide alkaloids in the seeds of Ziziphus jujuba var. spinosa (Semen Ziziphi Spinosae), which is a commonly used herb in Chinese and Korean traditional medicines. Considering the basicity of cyclopeptide alkaloids, a specific separation method was developed for an UHPLC system. The compounds were detected by DAD and ESI-qTOF-MS, and their fragmentation patterns were also acquired by MSE technologies. Peak-picking of major compounds was performed with nine previously isolated compounds and two reference standard compounds. Tandem MS fragmentation behaviors of type-Ia and -Ib cyclopeptide alkaloids were investigated with the acquired data to develop a strategy for dereplication of other cyclopeptide alkaloid compounds in Z. jujuba var. spinosa. Two more cyclopeptide alkaloids were tentatively identified with UHPLC-ESI-qTOF-MS using this method.
 Keywords
Cyclopeptide alkaloids;UHPLC-ESI-qTOF-MS;Ziziphus jujuba var. spinosa;
 Language
English
 Cited by
1.
Comparison of the Bioactive Components in Two Seeds of Ziziphus Species by Different Analytical Approaches Combined with Chemometrics, Frontiers in Pharmacology, 2017, 8  crossref(new windwow)
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